Article
Microbiology
Yao Wang, Bo Pang, Zequn Wang, Xueying Tian, Xiaoying Xu, Xiaowen Chong, Hao Liang, Wei Ma, Zengqiang Kou, Hongling Wen
Summary: Conducting an up-to-date analysis on the genomic diversity and evolution patterns of severe fever with thrombocytopenia syndrome virus (SFTSV) is crucial for understanding its emergency and pathogenicity, as well as assessing its threat to public health.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Shuzo Urata, Jiro Yasuda, Masaharu Iwasaki
Summary: Loperamide inhibited SFTSV propagation in cell lines by blocking post-entry steps and restricting calcium influx. This suggests that loperamide, an FDA-approved drug, has potential as a treatment option for SFTS.
Article
Medicine, General & Internal
Zhenxing Li, Zhaoru Zhang, Chong Chen
Summary: This study developed two critical risk nomograms based on indicators for predicting mortality risk in SFTS patients, with the model incorporating viral load displaying better predictive accuracy. These models will provide frontline clinicians with a convenient tool for early identification of critically ill patients and initiation of better personalized treatment in a timely manner.
FRONTIERS IN MEDICINE
(2023)
Article
Microbiology
Mi-Young Moon, Hyeon Kyu Kim, Se-Jin Chung, Jae Hwan Byun, Ha-Na Kim, Woan Lee, Soon-Won Lee, Sezim Monoldorova, Sungkyeong Lee, Bo-Young Jeon, Eun-Joo Lim
Summary: This study investigated the clinical and epidemiological characteristics of severe fever with thrombocytopenia syndrome (SFTS) in Gangwon Province, Korea, from 2019 to 2021. The findings revealed that SFTS occurred throughout the province, with Hwacheon having the highest incidence density. Multiple genotypes of SFTS were identified, with B2 and A being the most common. These findings provide important insights for the understanding and management of SFTS in this region.
Letter
Immunology
Patthaya Rattanakomol, Sarawut Khongwichit, Piyada Linsuwanon, Keun Hwa Lee, Sompong Vongpunsawad, Yong Poovorawan
Summary: This study identified 3 patients with SFTS in or near Bangkok, Thailand, highlighting the importance for clinicians to be aware of possible SFTS virus, even in urban centers.
EMERGING INFECTIOUS DISEASES
(2022)
Letter
Immunology
Tatsuya Fujikawa, Tomoki Yoshikawa, Takeshi Kurosu, Masayuki Shimojima, Masayuki Saijo, Kyoko Yokota
Summary: A febrile woman in Japan was diagnosed with severe fever with thrombocytopenia syndrome after a tick bite, but retrospectively, Rickettsia japonica DNA was detected in the eschar specimen, suggesting a possible co-infection. The establishment of severe fever with thrombocytopenia syndrome virus infection may have dominated the R. japonica infection.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Zhipeng Zu, Haijiang Lin, Yafei Hu, Xiang Zheng, Cairong Chen, Yishuang Zhao, Na He
Summary: This study conducted a genetic and codon usage bias analysis of SFTSV, a newly emerging zoonotic infectious disease. The results revealed the increasing genetic diversity of SFTSV and identified host-specific codon usage patterns. The study also demonstrated that the codon usage bias of SFTSV was mainly driven by natural selection.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Microbiology
Min Wang, Peng Huang, Wei Liu, Weilong Tan, Tianyan Chen, Tian Zeng, Chuanlong Zhu, Jianguo Shao, Hong Xue, Jun Li, Ming Yue
Summary: This study aimed to explore risk factors for central neurological complications in patients with severe fever with thrombocytopenia syndrome (SFTS). The results showed that pulmonary rales, atrial fibrillation, as well as high serum SFTSV RNA and lactate dehydrogenase levels during the fever stage were independent risk factors for the development of central neurological complications in SFTS patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Tao Yang, Huaying Huang, Longfeng Jiang, Jun Li
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus (SFTSV). The global prevalence of SFTSV infection is increasing annually, with a mortality rate estimated between 5-30%. Due to the lack of understanding of the transmission and pathogenesis of SFTSV, as well as the host immune response, there are currently no effective treatments available. Therefore, researching the host immune response against SFTSV is of great importance in developing novel therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Virology
Yin Zhang, Wen Miao, Yuanhong Xu, Ying Huang
Summary: This study described the clinical features, risk factors, outcome factors, and ribavirin therapeutic efficacy for severe fever with thrombocytopenia syndrome (SFTS) patients in Hefei. Clinical features, prognostic factors, and risk factors associated with SFTS in Hefei are similar to those in other areas. Patients treated with ribavirin did not show better survival rates compared to those who were not treated with ribavirin.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Wentao He, Xiaoyi Liu
Summary: This study analyzed the clinical data of COVID-19 and SFTS patients, and found that PLT, FIB, and TNF-α have definitive clinical value for the early and differential diagnosis of these two infections. The findings suggest that these parameters could be important in distinguishing between COVID-19 and SFTS at an early stage of infection.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Haida Ding, Xian Qi, Carol J. Cardona, Zheng Xing
Summary: Infection with SFTS virus can activate the NLRP3 inflammasome and induce IL-1 beta secretion in the brains of infected newborn mice. This study reveals a novel mechanism by which SFTSV dysregulates host responses through its nonstructural protein, providing insights into viral neuropathogenesis in SFTS patients.
JOURNAL OF VIROLOGY
(2022)
Review
Virology
Jun-Won Seo, Dayoung Kim, Nara Yun, Dong-Min Kim
Summary: SFTS is an acute febrile illness caused by the SFTSV virus, primarily transmitted by tick bites, with a high mortality rate and lack of established treatment strategies. Current treatments for SFTS include antiviral agents and other specific methods.
Article
Pharmacology & Pharmacy
Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a novel phlebovirus (SFTSV) with high mortality. Peptides SGc1 and SGc8 derived from the SFTSV glycoprotein Gc have shown potential as specific antiviral therapeutics by inhibiting SFTSV replication effectively.
ANTIVIRAL RESEARCH
(2021)
Article
Infectious Diseases
Yumani Kuba, Hisako Kyan, Yasuhito Azama, Yoshimune Fukuchi, Eun-Sil Park, Tetsuya Kakita, Minori Oyama, Noriyuki Maeshiro, Masato Miyahira, Minoru Nidaira, Ken Maeda, Shigeru Morikawa, Kiyosu Taniguchi
Summary: The first case of SFTS in Okinawa, Japan was confirmed in August 2016, and subsequent investigations found anti-SFTSV antibodies in wild mongooses but not in human inhabitants. Outdoor activity was identified as a risk factor for tick bites among Okinawa residents. Despite the current low frequency of SFTSV infection in animals and humans, monitoring for future infections is recommended.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Cell & Tissue Engineering
Qiming Liang, Zhifei Luo, Jianxiong Zeng, Weiqiang Chen, Suan-Sin Foo, Shin-Ae Lee, Jianning Ge, Su Wang, Steven A. Goldman, Berislav V. Zlokovic, Zhen Zhao, Jae U. Jung
Article
Cell Biology
Zhifei Luo, Suhn Kyong Rhie, Fides D. Lay, Peggy J. Farnham
Article
Biochemistry & Molecular Biology
Suhn Kyong Rhie, Lijun Yao, Zhifei Luo, Heather Witt, Shannon Schreiner, Yu Guo, Andrew A. Perez, Peggy J. Farnham
Review
Oncology
Zhifei Luo, Suhn K. Rhie, Peggy J. Farnham
Article
Cell Biology
Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yang, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav Zlokovic, Zhen Zhao, Jae U. Jung
Article
Multidisciplinary Sciences
Zhifei Luo, Peggy J. Farnham
Article
Cell & Tissue Engineering
Jianxiong Zeng, Shupeng Dong, Zhifei Luo, Xiaochun Xie, Bishi Fu, Ping Li, Chengrong Liu, Xing Yang, Yujie Chen, Xin Wang, Zhenshan Liu, Jing Wu, Youzhen Yan, Feng Wang, Jian-Fu Chen, Jian Zhang, Gang Long, Steven A. Goldman, Shitao Li, Zhen Zhao, Qiming Liang
Article
Immunology
Jianxiong Zeng, Zhifei Luo, Shupeng Dong, Xiaochun Xie, Xinyan Liang, Youzhen Yan, Qiming Liang, Zhen Zhao
Summary: The study identified a complex interaction network between ZIKV-derived viRNAs and their viral RNA targets, demonstrating that viRNA production from ZIKV mRNA depends on Dicer function and is a limiting factor for ZIKV virulence in NSCs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Yi-Tsung Lu, Tong Xu, Maheen Iqbal, Tien-Chan Hsieh, Zhifei Luo, Gangning Liang, Peggy J. Farnham, Suhn K. Rhie, Amir Goldkorn
Summary: This research found that in bladder cancer, the transcription factor FOXC1 promotes the shift towards cisplatin resistance by binding accessible enhancers, even without mutational events. Targeting FOXC1 may be a new therapeutic approach to mitigate cisplatin resistance and improve treatment efficacy in bladder cancer.
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.
