Article
Zoology
Maria Prado-Alvarez, Pablo Garcia-Fernandez, Nicole Faury, Carlos Azevedo, Benjamin Morga, Camino Gestal
Summary: The study found that the ostreid herpes virus was detected for the first time in octopus, indicating the presence of viral material in the environment. Experimental results showed a significant impact of the virus on octopus paralarvae, and activated the immune defense of octopus.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Immunology
Maxime Lepretre, Nicole Faury, Amelie Segarra, Stephane Claverol, Lionel Degremont, Melissa Palos-Ladeiro, Jean Armengaud, Tristan Renault, Benjamin Morga
Summary: This study focused on experimental infection of Pacific oyster spat with ostreid herpesvirus type 1 (OsHV-1) and identified viral proteins with potential immunomodulatory functions, as well as key proteins in the host immune response against the viral infection. The results suggest that OsHV-1 may manipulate the host immune response, leading to weakening and death of Pacific oysters, while also highlighting the importance of proteins involved in RNA interference and interferon-like pathways for antiviral defenses in Pacific oysters.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Yen Larry Wu, Qiaoyun Ai, Rita Teresa Teixeira, Phong H. T. Nguyen, Gaoyuan Song, Christian Montes, J. Mitch Elmore, Justin W. Walley, Polly Yingshan Hsu
Summary: By improving the coverage of super-resolution Ribo-seq, previously uncharacterized translation events for nuclear, chloroplastic, and mitochondrial genes in Arabidopsis have been revealed. These events include untranslated ORFs in noncoding RNAs. Proteomic data confirmed the production of stable proteins from some of these unannotated translation events.
Article
Fisheries
Chang-Ming Bai, Xiang Zhang, Paola Venier, Li Gu, Ya-Nan Li, Chong-Ming Wang, Lu-Sheng Xin, Umberto Rosani
Summary: This study investigated the transcriptional changes in blood clam during OsHV-1 infection using miRNA and total RNA-seq data. It was found that the down-regulation of host metabolic and energetic processes mediated by miRNA may be a possible antiviral strategy during early infection stages, while the activation of immune genes mainly occurred in the late stage of infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel Oyanedel, Arnaud Lagorce, Maxime Bruto, Philippe Haffner, Amandine Morot, Yannick Labreuche, Yann Dorant, Sebastien de La Forest Divonne, Francois Delavat, Nicolas Inguimbert, Caroline Montagnani, Benjamin Morga, Eve Toulza, Cristian Chaparro, Jean-Michel Escoubas, Yannick Gueguen, Jeremie Vidal-Dupiol, Julien de Lorgeril, Bruno Petton, Lionel Degremont, Delphine Tourbiez, Lea-Lou Pimpare, Marc Leroy, Oceane Romatif, Juliette Pouzadoux, Guillaume Mitta, Frederique Le Roux, Guillaume M. Charriere, Marie-Agnes Travers, Delphine Destoumieux-Garzon
Summary: In Pacific Oyster Mortality Syndrome (POMS), Vibrio harveyi and ostreid herpesvirus 1 (OsHV-1) are the predominant bacteria causing the disease. V. harveyi synergizes with OsHV-1 by promoting mutual growth and inhibiting oyster's cellular defenses. Furthermore, V. harveyi produces metabolites that benefit the growth of coexisting V. rotiferianus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Bowen Huang, Xiang Zhang, Qin Liu, Changming Bai, Chen Li, Chongming Wang, Lusheng Xin
Summary: In this study, the researchers found that OsHV-1 infection in ark clams can suppress the post-transcriptional translation of SbFn by regulating SbIRP-1, thereby evading host iron limitation.
Article
Environmental Sciences
Xiaoran Duan, Hongmei Wang, Yongli Yang, Pengpeng Wang, Hui Zhang, Bin Liu, Wan Wei, Wu Yao, Xiaoshan Zhou, Jie Zhao, Wei Wang
Summary: This study suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) in workers may lead to telomere shortening, while genetic variations in the TEP1 gene could affect telomere length. Specifically, carrying the TEP1 rs1760903 CC genotype may be protective against telomere shortening. These findings highlight the roles of environmental factors and genetic variations in telomere damage, providing a basis for early detection of susceptible populations and establishment of occupational standards.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Benjamin Morga, Maude Jacquot, Camille Pelletier, Germain Chevignon, Lionel Degremont, Antoine Bietry, Jean-Francois Pepin, Serge Heurtebise, Jean-Michel Escoubas, Tim P. Bean, Umberto Rosani, Chang-Ming Bai, Tristan Renault, Jean-Baptiste Lamy
Summary: The mechanisms of virus emergence are poorly understood, making outbreaks unpredictable. Whole-genome sequencing can reveal genetic variation and evolution in microbial pathogens. A study on Ostreid herpesvirus 1 showed genetic diversity has arisen in the past three decades, with spatial structuration of viral populations and evidence of selective pressures affecting specific genomic regions.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Kara J. O'Keefe, Sharon Pipkin, Robin Fatch, Susan Scheer, Teri Liegler, Willi McFarland, Robert M. Grant, Hong-Ha M. Truong
Summary: The frequency of non-B subtypes and CRFs increased in San Francisco during 2000-2016, with most non-B infections likely being acquired outside the US. Local transmission of non-B forms has occurred, but has not led to extensive transmission networks. Non-B variants were not widely established in San Francisco, in contrast to cities worldwide with more diverse epidemics.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Infectious Diseases
Sailen Barik
Summary: This study conducted a comparative analysis of ORF proteins in coronaviruses, revealing that even within the same genus, the gene order or naming of the ORFs were not fully conserved. Additionally, previously unrecognized ORFs in alternative translational frames were identified, leading to the proposal of systematic numbering for ORF genes in the viral genome to standardize names and orders.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Cell Biology
Valter Lubrano, Silvana Balzan, Angela Papa
Summary: Atherosclerosis is a major cause of cerebral infarction and other ischemic cardio-cerebrovascular diseases. Despite the benefits of lipid-lowering therapies, many patients who have achieved their lipid-lowering goals still face a high risk of cardiovascular disease. LOX-1, a scavenger receptor that accepts oxidized low-density lipoproteins, plays a crucial role in atherosclerosis progression. Other factors such as cytokines, shear stress, and advanced glycation end-products can also affect LOX-1 expression. The OLR1 gene, encoding LOX-1, has different isoforms induced by splicing or single-nucleotide polymorphisms (SNPs), which can have varying effects on atherosclerosis and cardiovascular disease. Understanding these variants can lead to the development of new preventive therapies and the identification of individuals at a higher risk of cardiovascular events.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ana Triguero-Martinez, Emilia Roy-Vallejo, Nuria Montes, Hortensia de la Fuente, Ana Maria Ortiz, Santos Castaneda, Isidoro Gonzalez-Alvaro, Amalia Lamana
Summary: A study found that genetic variants in the LGALS1 gene are associated with Gal1 serum levels, and these genetic variants can explain the differences in Gal1 levels among patients, with higher levels of Gal1 being associated with lower levels of IL-6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yang Chen, Min Shen, Chen Ji, Yanqian Huang, Yun Shi, Li Ji, Yao Qin, Yong Gu, Qi Fu, Heng Chen, Kuanfeng Xu, Tao Yang
Summary: N6-methyladenosine (m6A) and its genetic variants have been implicated in the regulation of the immune system in type 1 diabetes (T1D). In this study, the researchers identified intronic variants in PRRC2A and YTHDC2 that are associated with T1D risk in a Chinese Han population. The findings suggest that PRRC2A rs2260051[T] may disrupt immune homeostasis by affecting the expression of PRRC2A mRNA. These results contribute to our understanding of the pathogenesis of T1D and the role of m6A regulators.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Virology
Suzanne Trancart, Alison Tweedie, Olivia Liu, Ika Paul-Pont, Paul Hick, Maryline Houssin, Richard J. Whittington
Summary: Since 2010, mass mortality events known as Pacific oyster mortality syndrome (POMS) have occurred in Crassostrea gigas in Australia associated with Ostreid herpesvirus 1. The genetic identity and diversity of the virus in Australia were determined, revealing multiple variants and a distinct cluster of OsHV-1 isolates in Australia. The sequencing findings supported prior epidemiological evidence for environmental reservoirs of OsHV-1 for POMS outbreaks in Australia.
Article
Environmental Sciences
Charles Vanhuysse, Julien Normand, Melanie Lepoittevin, Francis Orvain
Summary: Oyster farming in intertidal areas creates a distinct pattern that affects the spatial organization of macrozoobenthic communities. This study found that the oyster table habitat was in poor ecological condition, while eutrophication in the aisle was linked to dead seaweed stranding. The disturbance of species assemblage occurred in two phases, potentially impacting different macrofaunal indicators.
MARINE POLLUTION BULLETIN
(2021)
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.