Journal
VIRUS RESEARCH
Volume 163, Issue 2, Pages 439-447Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2011.11.006
Keywords
Hantavirus; Phylogeny; Rodents
Categories
Funding
- National High Technology Research and Development 863 Program of China [2007AA02Z465]
- National Natural Science Foundation of China (NSFC) [30770096]
- National Natural Science Foundation of Jiangsu province [BK2010537]
- State Key Laboratory of Virology [2010006]
- Scientific Research Foundation of the State Education Ministry for Returned Chinese Scholars [30115]
- Fundamental Research Funds for the Central Universities [3082003]
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Hantaan virus (HTNV) and Seoul virus (SEOV) are two major zoonotic pathogens of hemorrhagic fever with renal syndrome (HFRS) in Asia. Hubei province, which is located in the central-south China, had been one of the most severe epidemic areas of HFRS. To investigate phylogenetic relationships, genetic diversity and geographic distribution of HTNV and SEOV in their reservoir hosts, a total of 687 rodents were trapped in this area between 2000 and 2009. Sequences of partial S- and M-segments of hantaviruses and mitochondrial D-loop gene from 30 positive samples were determined. Our data indicated that SEOV and HTNV were co-circulating in Hubei. Phylogenetic analysis based on partial S- and M-segment sequences revealed two and three previously undefined lineages of SEOV, and a novel genetic lineage of HTNV, respectively. Four inter-lineage reassortment SEOVs carried by Rattus norvegicus and Apodemus agrarius were observed. It suggests that SEOV may cause spillover infections to A. agrarius naturally. The abundance of the phylogenetic lineages of SEOV suggested that central-south China was a radiation center for SEOVs. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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