Journal
VIRUS RESEARCH
Volume 137, Issue 1, Pages 142-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2008.05.013
Keywords
tick-borne encephalitis virus; ticks; tick cell line; vectors
Categories
Funding
- Ministry of Education, Youth and Sports of the Czech Republic [Z60220518, MSM 6007665801, LC 06009]
- Grant Agency of the Czech Republic [570/3035, 524/08/1509]
- Wellcome Trust [075799]
- European Union [FP6-003713]
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We undertook a comparative Study of the susceptibility of different tick cell lines to infection with the European subtype of tick-borne encephalitis virus (TBEV), prototype strain Neudoerfl. The growth of TBEV was investigated in lines derived from vector Ixodes ricinus L. ticks (IRE/CTVM18,19, and 20),as well as non-vector ticks, namely Nodes scapulatis Say (IDE2), Boophilus microplus Canestrini (BME/CTVM2), Hyalomma anatolicum anatolicum Koch (HAE/CTVM9), Rhipicephalus appendiculatus Neumann (RA-257) and recently established and herein described lines from the argasid tick Ornithodoros moubata Murray (OME/CTVM21 and 22). All the tick cell lines tested were susceptible to infection by TBEV and the virus caused productive infection without any cytopathic effect. However, there was a clear difference between the TBEV growth in vector and non-vector cell lines, since l. ricinus cell lines produced 100-1000-fold higher virus yield than the non-vector cell lines. The lowest virus production was observed in O. moubata and R. appendiculatus cell lines. (C) 2008 Elsevier B.V. All rights reserved.
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