Journal
VIRUS GENES
Volume 41, Issue 3, Pages 459-468Publisher
SPRINGER
DOI: 10.1007/s11262-010-0532-1
Keywords
Lysis inhibition; Accessory genes; Bacteriophage T4
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Funding
- Ministry of Science and Higher Education [2P04A 056 29]
- Foundation for Polish Science
- Foundation for Development of University of Gdansk
- Ministry of Science and Higher Eduction (Poland)
- European Union [POIG.01.01.02-00-008/08]
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Lysis inhibition (LIN) is a known feature of the T-even family of bacteriophages. Despite its historical role in the development of modern molecular genetics, many aspects of this phenomenon remain mostly unexplained. The key element of LIN is an interaction between two phage-encoded proteins, the T holin and the RI antiholin. This interaction is stabilized by RIII. In this report, we demonstrate the results of genetic experiments which suggest a synergistic action of two accessory proteins of bacteriophage T4, RI.-1, and RI.1 with RIII in the regulation of LIN.
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