Article
Virology
Jonathan Arzt, Ian H. Fish, Miranda R. Bertram, George R. Smoliga, Ethan J. Hartwig, Steven J. Pauszek, Lauren Holinka-Patterson, Fayna C. Diaz-San Segundo, Tatjana Sitt, Elizabeth Rieder, Carolina Stenfeldt
Summary: Research showed that cattle can be simultaneously infected with two different serotypes of foot-and-mouth disease virus (FMDV), with different outcomes depending on the timing of exposure to the viruses. Dominant interserotypic recombinant FMDVs were discovered in upper respiratory tract samples of superinfected animals, indicating the potential role of persistently infected FMDV carriers in generating novel viral strains.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yun-Jung Hwang, Kyung-Kwan Lee, Jong-Won Kim, Kwang-Hyo Chung, Sang-Jick Kim, Wan-Soo Yun, Chang-Soo Lee
Summary: The study introduces an optical and electrochemical dual-modal approach for the specific detection of foot-and-mouth disease virus serotypes O and A, offering high sensitivity and accuracy.
Article
Microbiology
Morgan Sarry, Cindy Bernelin-Cottet, Caroline Michaud, Anthony Relmy, Aurore Romey, Anne-Laure Salomez, Patricia Renson, Maud Contrant, Maxime Berthaud, Helene Huet, Gregory Jouvion, Sara Hagglund, Jean-Francois Valarcher, Labib Bakkali Kassimi, Sandra Blaise-Boisseau
Summary: Foot-and-mouth disease (FMD) is a highly contagious viral disease that has a significant socio-economic impact on cloven-hoofed animals. While persistence of FMDV has been observed in cattle and small ruminants, it is unlikely to occur in pigs. Lack of suitable in vitro models has hindered the progress in understanding FMDV persistence and differential persistence.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Asela Weerawardhana, Md Bashir Uddin, Joo-Hyung Choi, Prabuddha Pathinayake, Sung Ho Shin, Kiramage Chathuranga, Jong-Hyeon Park, Jong-Soo Lee
Summary: The study reveals that the 2B protein of foot-and-mouth disease virus (FMDV) modulates the host interferon (IFN) signaling pathway by degrading RIG-I and MDA5 proteins, leading to inhibition of IFN production. This finding provides valuable insights into the immune evasion mechanism of FMDV and offers a rational approach for virus attenuation in vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Danielle M. M. Pierce, Connor Hayward, David J. J. Rowlands, Nicola J. J. Stonehouse, Morgan R. R. Herod
Summary: FMDV is the causative agent of FMD, a significant disease in farmed animals that can result in major economic losses. The replication of this virus involves a highly coordinated processing of nonstructural proteins within membrane-associated compartments. Mutations at the 3B(3)-3C boundary increase the rate of proteolysis and affect the production of enzymatic nonstructural proteins.
JOURNAL OF VIROLOGY
(2023)
Article
Veterinary Sciences
Ryan A. Waters, Jemma Wadsworth, Valerie Mioulet, Andrew E. Shaw, Nick J. Knowles, Darab Abdollahi, Reza Hassanzadeh, Keith Sumption, Donald P. King
Summary: Foot-and-mouth disease is a highly infectious viral disease affecting animals in the order Artiodactyla. This study demonstrates for the first time that FMD virus can replicate in dogs, potentially playing a significant role in FMD transmission.
BMC VETERINARY RESEARCH
(2021)
Article
Immunology
Victoria Primavera, Janine Simmons, Benjamin A. Clark, John G. Neilan, Michael Puckette
Summary: The inclusion of 2B into FMD molecular vaccine constructs enhanced transgene expression when a wildtype 3C protease is present but was detrimental to transgene expression with the 3C(L127P) mutant. This has implications for future molecular FMD vaccine constructs, which may utilize mutant FMDV 3C proteases.
Article
Microbiology
Ian Fish, Carolina Stenfeldt, Edward Spinard, Gisselle N. Medina, Paul A. Azzinaro, Miranda R. Bertram, Lauren Holinka, George R. Smoliga, Ethan J. Hartwig, Teresa de Los Santos, Jonathan Arzt
Summary: Viral recombination plays a crucial role in the emergence of novel strains, driven by the immune pressure of the host and changes in virus populations.
Article
Virology
Keshan Zhang, Minghao Yan, Junhong Hao, Chaochao Shen, Zixiang Zhu, Dajun Zhang, Jing Hou, Guowei Xu, Dan Li, Haixue Zheng, Xiangtao Liu
Summary: This study reveals the antiviral effect of host TPL2 during FMDV replication in promoting interferons and antiviral cytokines. FMDV and VP1 protein reduce host TPL2, ABIN2, and p105 to disrupt the TPL2-p105-ABIN2 trimer complex, leading to repression of TPL2-mediated antivirus activity. Vice protein interacts with TPL2 and degrades it through the proteasome pathway, shedding light on FMDV evasion mechanisms against host antivirus responses.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Carolina Stenfeldt, Ian Fish, Haillie C. Meek, Jonathan Arzt
Summary: This study investigates the pathogenesis of FMDV coinfections in cattle, showing that simultaneous infection does not lead to recombinant viruses, but heterologous superinfection of persistently infected carrier cattle does. The study also demonstrates a multifocal and heterogeneous distribution of FMDV infection in the nasopharyngeal tissue. These findings highlight the importance of FMDV carriers in the emergence of new recombinant strains.
Article
Virology
Kay Childs, Ben Jackson, Yongjie Harvey, Julian Seago
Summary: Foot-and-mouth disease is an economically devastating disease caused by foot-and-mouth disease virus (FMDV). Vaccination is the most effective control measure, but the antigenic diversity and rapid emergence of new strains hinder its success. The high error rate of the RNA-dependent RNA polymerase and extensive genome recombination during co-infection contribute to the diversity of FMDV.
Article
Virology
Chao Sui, Dandan Jiang, Xiangju Wu, Sidang Liu, Feng Li, Li Pan, Xiaoyan Cong, Juntong Li, Dongwan Yoo, Daniel L. Rock, Laura C. Miller, Changhee Lee, Yijun Du, Jing Qi
Summary: The leader protease (Lpro) of foot-and-mouth disease virus (FMDV) promotes viral replication by antagonizing the OAS/RNase L pathway and interfering with the host's innate immune response. This virus-host interaction is species-specific, only detected in swine cells, not in human, monkey, or canine cells. Additionally, Lpro inhibits apoptosis to promote cell survival.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Huisheng Liu, Qiao Xue, Zixiang Zhu, Fan Yang, Weijun Cao, Xiangtao Liu, Haixue Zheng
Summary: The study found that RIP2 inhibited the replication of foot-and-mouth disease virus (FMDV) and played an important role in the activation of the IFN-β and NF-κB signal pathways during FMDV infection. Specific regions of FMDV proteins were responsible for reducing RIP2 protein expression, with specific regions of 2B and 2C being crucial for this process.
Article
Virology
Yongjie Harvey, Ben Jackson, Brigid Veronica Carr, Kay Childs, Katy Moffat, Graham Freimanis, Chandana Tennakoon, Nicholas Juleff, Julian Seago
Summary: Foot-and-mouth disease (FMD) is a widespread disease that threatens food security and has severe economic impacts. Vaccination is the most effective control strategy, but current vaccines may not fully protect against different subtypes of the virus. Developing new vaccine strains is challenging due to difficulty in adapting the virus to cell culture. In this study, researchers have developed recombinant cell lines that express a key receptor for FMDV, which improves virus yield and can be used for future vaccine production.
Article
Virology
Ploypailin Semkum, Challika Kaewborisuth, Nattarat Thangthamniyom, Sirin Theerawatanasirikul, Chalermpol Lekcharoensuk, Payuda Hansoongnern, Pongrama Ramasoota, Porntippa Lekcharoensuk
Summary: Researchers have successfully established a novel DNA vector, pKLS3, for the FMDV minigenome system, which showed efficacy in cell-based antiviral drug screening. This system is not only useful for FMDV research and development but can also be implemented for generating minigenomes of other picornaviruses. Additionally, the potential applications of this viral minigenome system as a vector for DNA and mRNA vaccines are being discussed.