Journal
VIROLOGY JOURNAL
Volume 10, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1743-422X-10-163
Keywords
Canine parvovirus; VP2 gene; Point mutation; Phylogenetic analysis; Giant panda
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Funding
- Program for Changjiang Scholars and Innovative Research Team in University, China [IRT0848]
- Ministry of Science and Technology of the P.R. China [200910188]
- Science and Technology Department of Sichuan Province [2010SZ0050]
- National Key Technology RD Program [2012BAC01B06]
- Chengdu Giant panda Breeding Research Foundation
- National Basic Research Program of China (973 program) [2012CB722207]
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Background: In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China. Results: Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus. Conclusions: These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores.
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