Review
Immunology
Soren R. Paludan, Trine H. Mogensen
Summary: COVID-19 is a disease characterized by significant dysregulation of the innate immune system. The activation of specific pattern recognition receptors by SARS-CoV-2 and host-derived molecules leads to protective interferon responses and pathological cytokine responses. These pathways are modulated by virus-host interactions and host stress-sensing pathways.
SCIENCE IMMUNOLOGY
(2022)
Review
Immunology
Yean Kong Yong, Won Fen Wong, Ramachandran Vignesh, Indranil Chattopadhyay, Vijayakumar Velu, Hong Yien Tan, Ying Zhang, Marie Larsson, Esaki M. Shankar
Summary: This study reviews the latest research progress in understanding the immunopathogenesis of dengue and provides suggestions for targeted strategies against dengue.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Arshi Khanam, Hector Gutierrez-Barbosa, Kirsten E. Lyke, Joel V. Chua
Summary: Dengue virus infection is a major global public health concern, particularly in tropical regions. While most cases are mild or asymptomatic, a small percentage can develop into severe cases. The severity of dengue depends on immunopathogenic mechanisms involving both the virus and the host, with impaired immune response being a key factor in disease progression and severity.
Article
Multidisciplinary Sciences
Krishna Shrinivas, Michael P. Brenner
Summary: This study utilizes random-matrix theory and statistical physics to describe the emergent phase behavior of fluid mixtures with many molecular species. Through numerical simulation and stability analyses, it is found that these mixtures exhibit staged phaseseparation kinetics and have multiple coexisting phases at steady state with distinct compositions. The model framework provided in this study can help understand the dynamical and steady-state phase behavior of liquid-like mixtures with many interacting constituents.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh
Summary: This study confirms the presence of antibodies related to SARS-CoV-2 in dengue virus patients, and these antibodies can cross-react with proteins of the dengue virus. These antibodies can inhibit the pathological reactions caused by dengue virus infection, potentially providing some level of protection against dengue virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Abhay P. S. Rathore, Chinmay K. Mantri, Meredith W. Tan, Roksana Shirazi, Andrew Nishida, Siti A. B. Aman, Juliet Morrison, Ashley L. St. John
Summary: This study provides a comprehensive characterization of DENV1-4 infection in immune-competent mice and confirms the wild-type mouse model as a valid and reproducible system for investigating the mechanisms of DENV pathogenesis. The infection profiles of human clinical isolates of DENV serotypes 1-4 in the immune-competent mouse model were observed, along with the detection of replicating virus in key organs and identification of novel cellular targets. The study also showed that immune-competent mice sustain replicating infection and display signs of DENV disease similar to those in humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Irene Mattioli, Alessandra Bettiol, Guher Saruhan-Direskeneli, Haner Direskeneli, Giacomo Emmi
Summary: Behcet's syndrome is a rare systemic vasculitis with diverse clinical presentations. Although strongly associated with the genetic predisposing factor HLA-B * 51, the exact etiology behind the disease remains incompletely understood, with genetic, environmental, and immunological factors likely playing a role.
FRONTIERS IN MEDICINE
(2021)
Article
Entomology
Jameel M. Abduljalil, Fahd M. Abd Al Galil
Summary: Deciphering the molecular interactions between DENV and its vector is a promising field to develop efficient control strategies for DENV.
JOURNAL OF INSECT PHYSIOLOGY
(2022)
Review
Microbiology
Victor Edgar Fiestas Solorzano, Raquel Curtinhas de Lima, Elzinandes Leal de Azeredo
Summary: This study systematically reviewed the role of growth factors (GFs) in the pathogenesis of dengue. The findings showed that in severe dengue, levels of vascular endothelial growth factor and hepatocyte growth factor were increased, while platelet-derived growth factor and epidermal growth factor levels were reduced. Furthermore, evidence suggested that the dengue virus can exploit the growth factor pathway to facilitate its entry into cells and promote viral replication.
Review
Biochemistry & Molecular Biology
Anna Torres, Monika Zaborek-Lyczba, Jakub Lyczba, Paulina Mertowska, Sebastian Mertowski, Ewelina Grywalska
Summary: Pediatric lichen sclerosus (LS) is a chronic inflammatory skin condition that primarily affects the anogenital area and can lead to scarring if left untreated. The underlying mechanisms and risk factors of this condition are still not fully understood. This review aims to summarize existing research and discuss potential mechanisms and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Arpana Verma, Maninder Kaur, Princy Luthra, Lakshyaveer Singh, Divya Aggarwal, Indu Verma, Bishan D. D. Radotra, Sanjay Kumar Bhadada, Sadhna Sharma
Summary: Diabetes is a significant risk factor for latent tuberculosis activation and worsens tuberculosis treatment outcomes. The study focuses on understanding the interaction between M. tuberculosis and its host during latent tuberculosis infection under hyperglycemic conditions or diabetes. An animal model was used to study the relationship, and various host factors such as cytokines and MMPs were analyzed. The results showed that diabetes worsens the containment of mycobacterial infection and affects granuloma formation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Nguyen Lam Vuong, Ka-Wai Cheung, Balamurugan Periaswamy, Tran Thuy Vi, Huynh Thi Le Duyen, Yan Shan Leong, Zayanah Noor Binte Hamis, Michaela Gregorova, Eng Eong Ooi, October Sessions, Laura Rivino, Sophie Yacoub
Summary: Patients with severe dengue exhibit higher levels of inflammatory biomarkers, impaired NK cell function, and genetic variations in genes related to NK cell cytolytic function. These hyperinflammatory features are associated with dengue severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Pandikannan Krishnamoorthy, Athira S. Raj, Pramod Kumar, Nilanjana Das, Himanshu Kumar
Summary: This review summarizes the advances in understanding the interplay between the human host and DENV ncRNAs, particularly their role in regulating the host's innate immune system and their potential applications in dengue diagnosis and treatment.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Review
Microbiology
Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar
Summary: The pathogenesis of dengue virus infection involves a complex interplay between virus, host genes, and host immune response, with major determinants including host factors and viral determinants. Host factors include antibody-dependent enhancement, memory cross-reactive T cells, while viral determinants include NS1 protein, genomic variation, among others.
CURRENT MICROBIOLOGY
(2021)
Review
Tropical Medicine
Mahesh Chandra Sahu, Rakesh Kumar Samantaray, Aditi Pal, Sanghamitra Pati
Summary: Dengue fever, caused by the dengue virus, is a common vector-borne disease worldwide. The cases of dengue fever in India have been increasing in the past decade. Significant progress has been made in understanding various aspects of dengue, including pathogenesis, diagnosis, prevention strategies, immunological responses, and the role of vectors. Climate factors and temperature play a crucial role in the severity of dengue, and there is a need to improve climate-based disease forecasting models for effective control.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)