Journal
VIROLOGY
Volume 471, Issue -, Pages 61-71Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.10.004
Keywords
Erythroid precursor cells; Dengue; Thalassemia trait
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Funding
- Research Chair Grant from the National Science and Technology Development Agency (NSTDA)
- Thailand Research Fund [BRG5780004]
- Mahidol University [MU-PD_2014_06]
- Thai Royal Golden Jubilee Research Scholarship
- Thailand Graduate Institute of Science and Technology (TGIST) [PHD/0101/2553, TG-22-14-55-002D]
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Dengue is the most significant arthropod borne viral disease worldwide, and infection with the dengue virus causes a wide range of symptoms in humans, including bone marrow suppression. While the target cells of the virus remain poorly characterized, cells of the myeloid lineage have been shown to be important mediators of the disease. This study sought to determine whether erythroid precursor cells were susceptible to dengue virus infection, and whether erythroid cells from thalassemia trait carriers showed any protection against infection. Infection with a laboratory adapted high passage DENV-2 resulted in high levels of infection during certain stages of differentiation, and cells derived from thalassemia trait carriers showed significantly reduced susceptibility to dengue virus infection. Infection with low passage isolates resulted in only scattered cells showing evidence of infection, but high bystander apoptosis that was reduced by both a caspase 8 inhibitor and anti-tumor necrosis factor 1 receptor antibodies. (C) 2014 Elsevier Inc. All rights reserved.
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