Journal
VIROLOGY
Volume 435, Issue 1, Pages 1-13Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.10.016
Keywords
Baculovirus; Intracellular antiviral immunity; Apoptosis; Protein synthesis shutdown
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Funding
- Japan Society for the Promotion of Science (JSPS)
- JSPS
- Grants-in-Aid for Scientific Research [23380034, 11J08659, 23380033] Funding Source: KAKEN
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Innate immunity is essential for insects to survive infectious pathogens. In baculovirus-infected lepidopteran cells, apoptosis and global protein synthesis shutdown are major mechanisms of intracellular innate immunity that inhibit viral replication. In contrast, baculoviruses have evolved diverse genes and mechanisms to counter the antiviral immunity activated in infected cells. In this review, we summarize the current knowledge of the cellular antiviral pathways and the baculovirus genes that modulate antiviral immunity. The studies highlighted illustrate a high degree of diversity in both the cellular responses against viral infections and viral responses against intracellular antiviral immunity, providing an important basis of further studies in this field. (C) 2012 Elsevier Inc. All rights reserved.
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