Journal
VIROLOGY
Volume 443, Issue 1, Pages 99-105Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2013.04.028
Keywords
African swine fever virus; Attenuation; Virulence
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Funding
- BBSRC
- Biotechnology and Biological Sciences Research Council [BBS/E/I/00001709, BBS/E/I/00001714] Funding Source: researchfish
- BBSRC [BBS/E/I/00001714, BBS/E/I/00001709] Funding Source: UKRI
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African swine fever virus (ASFV) causes an acute haemorrhagic disease of domestic pigs against which there is no effective vaccine. The attenuated ASFV strain OUR T88/3 has been shown previously to protect vaccinated pigs against challenge with some virulent strains including OUR T88/1. Two genes, DP71L and DP96R were deleted from the OUR T88/3 genome to create recombinant virus OUR T88/3 Delta DP2. Deletion of these genes from virulent viruses has previously been shown to reduce ASFV virulence in domestic pigs. Groups of 6 pigs were immunised with deletion virus OUR T88/3 Delta DP2 or parental virus OUR T88/3 and challenged with virulent OUR T88/1 virus. Four pigs (66%) were protected by inoculation with the deletion virus OUR T88/3 Delta DP2 compared to 100% protection with the parental virus OUR T88/3. Thus the deletion of the two genes DP71L and DP96R from OUR T88/3 strain reduced its ability to protect pigs against challenge with virulent virus. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
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