Journal
VIROLOGY
Volume 402, Issue 2, Pages 223-227Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.03.048
Keywords
HIV-1 subtype B'; Injecting drug user (IDU); Former plasma donor (FPD); Phylogeny; Bayesian coalescent analysis; Time of the most recent common ancestor (tMRCA); Southeast Asia; China
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Funding
- Ministry of Health, Labor and Welfare [H18-AIDS-General-016]
- Ministry of Education, Culture, Sports, Science and Technology
- Japanese Foundation for AIDS Prevention (JFAP)
- Royal Society
- Human Sciences Foundation
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We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved.
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