Article
Multidisciplinary Sciences
Sri Masyeni, Rois Muqsith Fatawy, A. A. A. L. Paramasatiari, Ananda Maheraditya, Ratna Kartika Dewi, N. W. Winianti, Agus Santosa, Marta Setiabudy, Nyoman Trisna Sumadewi, Sianny Herawati
Summary: This study conducted in Bali among healthy and ill adults revealed a high prevalence of asymptomatic dengue cases and identified a significant association between age and health status in dengue seropositivity.
Article
Medicine, General & Internal
Boram Choi, Yoojin Na, Min Yeop Whang, Jung Yoon Ho, Mi-Ryung Han, Seong-Woo Park, Heekyoung Song, Soo Young Hur, Youn Jin Choi
Summary: In this study, the association between MGMT methylation and persistent HPV infection was examined using cervical cytology samples and a public database. The results showed that MGMT methylation was associated with HPV infection and downregulated MGMT mRNA expression correlated with poor overall survival. MGMT methylation level could potentially serve as a prognostic indicator for the transition from atypical squamous cells/low-grade squamous intraepithelial lesion to cervical cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Laura Teblick, Jade Pattyn, Severien Van Keer, Annemie De Smet, Ilse De Coster, Wiebren A. A. Tjalma, Ira Rajbhandari, Gitika Panicker, Elizabeth R. Unger, Alex Vorsters
Summary: This study explores the potential use of first-void urine as a noninvasive alternative sample for assessing humoral immune responses following HPV vaccination. The results show that first-void urine can detect HPV-specific antibody concentrations, with significant correlations to serum samples at different time points.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Zhen Dong, Renjian Hu, Yan Du, Li Tan, Lin Li, Juan Du, Longchang Bai, Yingkang Ma, Hongjuan Cui
Summary: HPV infection is a major cause of malignant neoplasms, and early diagnosis and therapy are crucial for the treatment of these diseases. Immunological methods offer precise strategies for accurate detection and blockade of HPV, providing promising avenues for the diagnosis and treatment of HPV-related cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Gypsyamber D'Souza, Sakshi R. Tewari, Tanya Troy, Tim Waterboer, Linda Struijk, Rachel Castillo, Hannah Wright, Michael Shen, Brett Miles, Mattias Johansson, Hilary A. Robbins, Carole Fakhry
Summary: The study evaluated the selection of screening population for oropharyngeal cancer and found that using risk factors for oral HPV can enrich the population with high-risk HPV biomarkers. The results showed that compared to the general population, the prevalence of HPV16 biomarkers in the eligible screening population was significantly elevated.
Article
Immunology
Laila Sara Arroyo Muhr, Carina Eklund, Camilla Lagheden, Tiina Eriksson, Ville N. Pimenoff, Penelope Gray, Matti Lehtinen, Joakim Dillner
Summary: The study compared antibody levels against human papillomavirus after different vaccinations. The findings showed that bivalent vaccination resulted in higher levels of antibodies against HPV16/18, while nonavalent vaccination resulted in higher levels of antibodies against HPV6/11/31/33/45/52/58.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Joseph E. Tota, Anna R. Giuliano, Stephen E. Goldstone, Brady Dubin, Alfred Saah, Alain Luxembourg, Christine Velicer, Joel M. Palefsky
Summary: The incidence of human papillomavirus (HPV)-related cancer is rising in men, and this study found that the prevalence of HPV infection and seropositivity is higher in men who have sex with men (MSM) compared to heterosexual men (HM). However, overall prevalence is still low. Catch-up vaccination after sexual debut may be beneficial.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Aya Sugiyama, Fumie Okada, Kanon Abe, Hirohito Imada, Serge Ouoba, E. Bunthen, Md Razeen Ashraf Hussain, Masayuki Ohisa, Ko Ko, Shintaro Nagashima, Tomoyuki Akita, Shinichi Yamazaki, Michiya Yokozaki, Eisaku Kishita, Junko Tanaka
Summary: This longitudinal study investigated the seroprevalence of prior SARS-CoV-2 infection in Hiroshima Prefecture, Japan. The results showed that the seroprevalence of anti-SARS-CoV-2 antibodies increased tenfold in six months, and Hiroshima had a smaller difference between seroprevalence and the prevalence of confirmed COVID-19 cases, suggesting active detection of asymptomatic patients.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2022)
Article
Immunology
Cameron Adams, Ramesh Jadi, Bruno Segovia-Chumbez, Jedas Daag, Michelle Ylade, Freddy A. Medina, Tyler M. Sharp, Jorge L. Munoz-Jordan, In-Kyu Yoon, Jacqueline Deen, Anna Lena Lopez, Aravinda M. de Silva, Lakshmanane Premkumar
Summary: The cross-reactivity between Zika virus and dengue virus makes it challenging to distinguish the two using traditional serologic assays, thus necessitating the development of improved detection methods. Studies have shown that in regions with dengue virus transmission, the use of a Zika virus envelope domain III-based assay can accurately assess Zika virus seroprevalence.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yan Tong, Philip Tonui, Omenge Orang'o, Jianjun Zhang, Titus Maina, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen, Aaron Ermel, Patrick Loehrer, Darron R. R. Brown
Summary: Kenyan women exposed to aflatoxin have an increased risk of HR-HPV persistence, suggesting a potential link between aflatoxin and cervical cancer.
BMC INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
K. F. Bennett, J. Waller, E. McBride, A. S. Forster, G. Di Gessa, H. Kitchener, L. A. Marlow
Summary: The study found that receiving an HPV-positive result following primary HPV testing can cause short-term psychosexual distress, especially among women with HPV-positive and normal or abnormal cytology results.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Infectious Diseases
Bolarinde J. Lawal, Katherine E. Gallagher, Jonathan Kitonsa, Daniel Tindanbil, Kambale Kasonia, Abdoulie Drammeh, Brett Lowe, Daniel Mukadi-Bamuleka, Catriona Patterson, Brian Greenwood, Mohamed Samai, Bailah Leigh, Kevin K. A. Tetteh, Eugene Ruzagira, Deborah Watson-Jones, Hugo Kavunga-Membo
Summary: The prevalence of IgG and IgM antibodies against four endemic human coronaviruses and two SARS-CoV-2 antigens was assessed among vaccinated and unvaccinated healthcare staff in Uganda, Sierra Leone, and the Democratic Republic of Congo. The results showed that the prevalence of antibodies against SARS-CoV-2 was high among unvaccinated participants and those with evidence of previous infection had higher IgG responses to vaccination. These findings suggest that natural and hybrid immunity should be considered in vaccination policies and prediction models.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Wenpei Shi, Haiyan Zhu, Lei Yuan, Xiaoyue Chen, Xiaojie Huang, Kai Wang, Zhen Li
Summary: This study aimed to investigate the association between vaginal microbiota and high-risk HPV infection. The results showed that women with a depletion of enterococcus ASV_62 and an enrichment in Lactobacillus iners at baseline were less likely to clear HPV infection within 12 months.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Zhenyu He, Lili Ren, Juntao Yang, Li Guo, Luzhao Feng, Chao Ma, Xia Wang, Zhiwei Leng, Xunliang Tong, Wang Zhou, Geng Wang, Ting Zhang, Yan Guo, Chao Wu, Qing Wang, Manqing Liu, Conghui Wang, Mengmeng Jia, Xuejiao Hu, Ying Wang, Xingxing Zhang, Rong Hu, Jingchuan Zhong, Jin Yang, Juan Dai, Lan Chen, Xiaoqi Zhou, Jianwei Wang, Weizhong Yang, Chen Wang
Summary: In a sample of the population in Wuhan, 6.92% developed antibodies against SARS-CoV-2, with 39.8% of this population having neutralizing antibodies. Data on humoral response durability indicates the need for mass vaccination to achieve herd immunity and prevent a resurgence of the epidemic.
Article
Microbiology
Mokhtar R. Gomaa, Amira S. El Rifay, Mahmoud Shehata, Ahmed Kandeil, Mina Nabil Kamel, Mohamed A. Marouf, Mohamed GabAllah, Ahmed El Taweel, Ahmed E. Kayed, Omnia Kutkat, Yassmin Moatasim, Sara H. Mahmoud, Noura M. Abo Shama, Mohamed El Sayes, Ahmed Mostafa, Rabeh El-Shesheny, Pamela P. McKenzie, Richard J. Webby, Ghazi Kayali, Mohamed A. Ali
Summary: The study in Egypt found a high household secondary attack rate of COVID-19, with most infections being asymptomatic or mild and resulting in a lasting neutralizing antibody response. Increasing public awareness about proper infection control within households may help reduce transmission in Egypt and similar areas.
Article
Environmental Sciences
Kyoko Miura, Minas Coroneo, Jean Claude Dusingize, Catherine M. Olsen, Rick Tinker, Ken Karipidis, Ian Hosegood, Adele C. Green
Summary: This study estimated the prevalence of cataract in pilots by analyzing medical records of commercial airline pilots diagnosed with cataract between 2011 and 2016. The results showed that the prevalence of cataract in pilots aged 60 and above was 11.6%, while it was only 0.5% in pilots aged below 60. The study also found that there was no significant difference in cataract prevalence based on the ambient ultraviolet radiation levels, although the lowest prevalence was observed in the low-UV state of Victoria. Furthermore, cataracts in pilots aged 60 and above were mostly bilateral and mild, while cataracts in pilots below 60 were more likely to be unilateral and severe.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Oncology
Mazvita Sengayi-Muchengeti, Elvira Singh, Wenlong Carl Chen, Debbie Bradshaw, Chantal Babb de Villiers, Robert Newton, Tim Waterboer, Christopher G. Mathew, Freddy Sitas
Summary: South Africa's HIV epidemic has had a significant impact on cancer patterns, with certain cancers such as Kaposi's sarcoma, lymphoma, and cervical cancer being associated with HIV. The association between conjunctival and HPV-related cancers and HIV continues to increase in the ART era.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Katrina Spilsbury, Karen M. M. Tuesley, Sallie-Anne Pearson, Michael D. D. Coory, Peter Donovan, Christopher B. B. Steer, Louise M. M. Stewart, Nirmala Pandeya, Susan J. J. Jordan
Summary: Surgery for epithelial ovarian cancer may activate stress-inflammatory responses that stimulate tumor growth. Observational studies have shown mixed results on the association between beta-blocker use and improved survival. This population-based study found that perioperative supply of nonselective beta-blockers conferred a survival advantage for women age over 50 years with a history of cardiovascular conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolas Tessandier, Ilkay Basak Uysal, Baptiste Elie, Christian Selinger, Claire Bernat, Vanina Boue, Sophie Grasset, Soraya Groc, Massilva Rahmoun, Bastien Reyne, Noemi Bender, Marine Bonneau, Christelle Graf, Vincent Tribout, Vincent Foulongne, Jacques Ravel, Tim Waterboer, Christophe Hirtz, Ignacio G. Bravo, Jacques Reynes, Michel Segondy, Carmen Lia Murall, Nathalie Boulle, Tsukushi Kamiya, Samuel Alizon
Summary: The study examines the association between the use of different types of menstrual products and microbial, immunological, demographic, and behavioral indicators. The results suggest a potential link between the use of menstrual cups and fungal genital infection, highlighting the possible influence of menstrual products on menstrual health.
Article
Dermatology
Ashley Ahimbisibwe, Morten Valberg, Adele C. Green, Reza Ghiasvand, Corina S. Rueegg, Raju Rimal, Elisabete Weiderpass, Torkjel M. Sandanger, Trude E. Robsahm, Marit B. Veierod
Summary: This study investigated the association between nevus count and pigmentary characteristics with melanoma-specific mortality. The study found that in patients with thicker melanoma, darker pigmentary characteristics were associated with a higher risk of melanoma death. However, in women with thicker melanoma, lighter pigmentary characteristics and asymmetrical nevi may be associated with lower melanoma-specific mortality.
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Dermatology
Catherine M. Olsen, Nirmala Pandeya, David C. Whiteman
Summary: This study aimed to describe the incidence trends of invasive melanoma by histological subtype and thickness in two populations with different approaches to early detection (the US White population and Queensland, Australia). The incidence of thick melanoma (> 4.00 mm) increased at a faster rate than thinner melanomas in both populations over the period 1999-2018, primarily driven by nodular melanomas. Thin melanomas (< 1.00 mm) were predominantly of superficial spreading subtype, while thick melanomas (> 4.00 mm) were dominated by nodular melanomas.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Dermatology
Nirmala Pandeya, Jean Claude Dusingize, Catherine M. Olsen, Stuart Macgregor, Rachel E. Neale, Matthew H. Law, David C. Whiteman
Summary: Genetic risk is weakly associated with melanoma incidence and screening behavior, but it does not explain the higher rate of melanoma detection between screened and unscreened individuals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Catherine M. Olsen, Nirmala Pandeya, Bruna S. Ragaini, Rachel E. Neale, David C. Whiteman
Summary: We compared the incidence trends of cutaneous SCC (cSCC) and melanoma in populations residing at mid-to-high latitudes and found that the ratio of cSCC-to-melanoma incidence increased with proximity to the equator and over time, especially in women.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Virology
Helmi Suominen, Nelli Suominen, Kari Syrjaenen, Tim Waterboer, Seija Grenman, Stina Syrjaenen, Karolina Louvanto
Summary: This study found that a second pregnancy does not have a significant impact on HPV antibody levels, but it may influence serological outcomes, especially in ongoing second pregnancies.
Article
Multidisciplinary Sciences
Samara B. Rifkin, Anna K. Miller, Eleazar E. Montalvan-Sanchez, Dalton A. Norwood, Enrique Martinez, Tim Waterboer, T. Mark Beasley, Ricardo L. Dominguez, Scott M. Williams, Douglas R. Morgan
Summary: A case-control study conducted in rural Honduras found that wood cookstove use, H. pylori CagA infection, and the rs1800440 genotype in the CYP1B1 gene were independently associated with gastric cancer risk. Furthermore, there was a significant interaction between wood cookstove use and the rs1800440 genotype.
SCIENTIFIC REPORTS
(2023)
Article
Pediatrics
Hanna K. Laine, Tim Waterboer, Kari Syrjanen, Seija Grenman, Karolina Louvanto, Stina Syrjanen
Summary: BK (BKPyV) and JC (JCPyV) polyomaviruses are common in infants, with high correlation of antibody levels between mother-infant pairs. The correlation differs between father-child pairs and may be related to predisposition to allergies.
Article
Biochemistry & Molecular Biology
G. H. Bernhard, S. Madronich, R. M. Lucas, S. N. Byrne, T. Schikowski, R. E. Neale
Summary: There are connections between COVID-19, solar UV radiation, and the Montreal Protocol. Solar UV radiation can inactivate the SARS-CoV-2 virus responsible for COVID-19, especially in the UV-A range. The new action spectrum suggests that solar UV radiation may be more effective in inactivating the virus than previously thought.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
R. E. Neale, R. M. Lucas, S. N. Byrne, L. Hollestein, L. E. Rhodes, S. Yazar, A. R. Young, M. Berwick, R. A. Ireland, C. M. Olsen
Summary: This assessment by the EEAP evaluates the effects of UV radiation on human health within the context of the Montreal Protocol. It reveals the harmful and beneficial effects of UV radiation on the immune system, skin cancer, eye diseases, and the production of vitamin D. It emphasizes the importance of prevention and the need to balance the risks and benefits of outdoor activities.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Dermatology
M. Shakeel, Z. Jiyad, M. Grant, M. G. Cook, D. Oudit, A. C. Green
Summary: The occurrence of lower limb melanoma in women is higher, but it varies across subsites and age groups. This might be linked to the relative influence of genetic and environmental risk factors.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
