Journal
VIROLOGY
Volume 394, Issue 2, Pages 298-310Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.08.032
Keywords
Peruvian horse sickness; Yunnan orbivirus; Orbivirus; Reoviridae; Peru; Australia; China; Neurological signs; Emerging viruses
Categories
Funding
- EU [QLK2-2000-00143]
- EU coordination action MedReoNet [044285]
- Defra
- BBSRC
- BBSRC [BB/D014204/1, BBS/E/I/00001446] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D014204/1, BBS/E/I/00001446] Funding Source: researchfish
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During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, 78% fatality) belongs to a new species the Peruvian horse sickness virus (PHSV), within the genus Orbivirus, family Reoviridae. This represents the first isolation of PHSV, which was subsequently also isolated during 1999, from diseased horses in the Northern Territory of Australia (Elsey virus, ELSV). Serological and molecular studies showed that PHSV and ELSV are very similar in the serotype-determining protein (99%, same serotype). The second virus (Rioja virus, RIOV) was associated with neurological signs in donkeys, cattle, sheep and dogs and was shown to be a member of the species Yunnan orbivirus (YUOV). RIOV and YUOV are also almost identical (97% amino acid identity) in the serotype-determining protein. YUOV was originally isolated from mosquitoes in China. (C) 2009 Elsevier Inc. All rights reserved.
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