Article
Biochemistry & Molecular Biology
Ilya B. Brodsky, Artem I. Fokin, Aleksei A. Efremov, Elena S. Nadezhdina, Anton V. Burakov
Summary: Membrane trafficking in interphase animal cells is carried out along microtubules, with the Golgi and centrosome serving as important microtubule organizing centers. Recent studies have revealed the role of Golgi-derived microtubules, but the differential expression of proteins and potential participants in this process are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Guo-Dong Zhao, Rong Gao, Xiao-Tao Hou, Hui Zhang, Xu-Tao Chen, Jin-Quan Luo, Hui-Fei Yang, Tong Chen, Xue Shen, Shi-Cong Yang, Cheng-Lin Wu, Gang Huang
Summary: This study investigates the molecular mechanism of cytoplasmic vacuolation caused by BK polyomavirus (BKPyV) and identifies a potential drug, Risedronate, for targeting DDIT3 in BKPyV-associated nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Aurel George Mohan, Bogdan Calenic, Nicu Adrian Ghiurau, Roxana-Maria Duncea-Borca, Alexandra-Elena Constantinescu, Ileana Constantinescu
Summary: This comprehensive review article delves into the Golgi apparatus, a crucial organelle in cellular biology. It discusses its unique organization and roles in maintaining cellular homeostasis through protein processing, sorting, and lipid biogenesis. The article also explores the relationship between Golgi function and neurodegenerative diseases, particularly Parkinson's, as well as the interplay between Golgi stress and endoplasmic reticulum stress in cellular stress response pathways. Overall, the review emphasizes the importance of further research in understanding Golgi dysfunction and its potential for targeted therapeutic approaches.
Article
Biochemistry & Molecular Biology
Nuomin Li, Yunjie Qiu, Hao Wang, Juan Zhao, Hong Qing
Summary: Neuritic plaques, major pathological features of Alzheimer's disease, are formed by the aggregation of A beta protein derived from APP cleavage by BACE1 and gamma-secretase, with mutations in PSEN1 gene affecting the activity of gamma-secretase and contributing to early onset familial Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Maud Wilhelm, Amandeep Kaur, Marion Wernli, Hans H. Hirsch
Summary: Using synthetic 27mer-long BKPyV peptides, different types of antigen-presenting cells, and CD4 T cells, BKPyV-specific CD8 T cell responses were expanded, providing a novel approach for vaccination and adoptive T-cell therapies for patients before and after kidney transplantation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Virology
Duncan W. Wilson
Summary: Alphaherpesviruses infect the mammalian nervous system through mucosal epithelia, establish latency in the peripheral nervous system, and rely on microtubule- and actin-dependent cellular motors for efficient transport of viral particles during assembly and egress.
Article
Microbiology
Mathieu Sikorski, Flora Coulon, Cecile Peltier, Cecile Braudeau, Alexandra Garcia, Matthieu Giraud, Karine Renaudin, Christine Kandel-Aznar, Steven Nedellec, Philippe Hulin, Julien Branchereau, Joelle Veziers, Pauline Gaboriaud, Antoine Touze, Julien Burlaud-Gaillard, Regis Josien, Dorian McIlroy, Celine Bressollette-Bodin, Franck Halary
Summary: BK polyomavirus (BKPyV) can cause polyomavirus-associated nephropathy (PVAN) in kidney transplant recipients due to immunosuppression, and dendritic cells (DCs) appear to play a role in BKPyV infection and spread. This study demonstrated that monocyte-derived dendritic cells (MDDCs) captured BKPyV particles through an unconventional endocytic pathway and could efficiently transmit virions to other cells. Freshly isolated CD1c(+) mDCs behaved similarly to MDDCs, suggesting a potential role in BKPyV infection. Further research is needed to understand the interaction between DC subsets and BKPyV as well as the immune response against the infection.
Article
Cell Biology
Elena Morelli, Elisa A. Speranza, Enrica Pellegrino, Galina Beznoussenko, Francesca Carminati, Massimiliano Garre, Alexander A. Mironov, Marco Onorati, Thomas Vaccari
Summary: Snap29 is a crucial regulator of membrane fusion, essential for cellular processes such as autophagy and cell division. Mutations in Snap29 can lead to alterations in Golgi apparatus and disrupted ER to GA trafficking, revealing a new regulatory function of Snap29 in promoting secretory trafficking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Long Han, Qinhui Rao, Renbin Yang, Yue Wang, Pengxin Chai, Yong Xiong, Kai Zhang
Summary: In this study, the authors solve cryo-EM structures of the central apparatus of motile cilia and analyze its dynamic conformations to elucidate the mechanism of ciliary beating.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pearl Cherry, Li Lu, Su Yeon Shim, Vincent Ebacher, Waqas Tahir, Hermann M. Schatzl, Samia Hannaoui, Sabine Gilch
Summary: Prion diseases are fatal and infectious neurodegenerative diseases caused by the misfolding of the cellular prion protein. PrPSc accumulation in prion-infected cells leads to neurodegeneration. Prion infection is associated with reduced levels of active Rab7 and elevated cholesterol levels. The impaired Rab7 activation is linked to altered lysosomal positioning and delayed trafficking of low-density lipoprotein to lysosomes, resulting in increased cholesterol levels. Over-expression of constitutively active Rab7 rescues these effects, attenuating PrPSc propagation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Cell Biology
Marlieke L. M. Jongsma, Nina Bakker, Jacques Neefjes
Summary: The endosomal system coordinates the transport of substances within cells, and its motion is regulated by microtubule-based motor proteins. These interactions determine the mobility of the endosomes.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska, Jacek Jaworski
Summary: mTOR inhibition enhances cargo transport through the secretory pathway, particularly in PC12 cells and primary human fibroblasts. Additionally, VSVg trafficking is increased in TSC1-deficient cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
David Prikryl, Mariana Marin, Tanay M. M. Desai, Yuhong Du, Haian Fu, Gregory B. B. Melikyan
Summary: Interferon-induced transmembrane proteins (IFITMs) block virus fusion through increasing membrane rigidity. CsA and CsH enhance virus fusion by inducing the rapid relocalization of IFITM1 and IFITM3 to the Golgi, without significant degradation of IFITMs. This redistribution represents the primary mechanism of virus entry enhancement.
Article
Immunology
Casey A. Dubrawka, Kristin J. Progar, Spenser E. January, Jennifer C. Hagopian, Nicole M. Nesselhauf, Andrew F. Malone
Summary: Discontinuation of antimetabolite after CMV or BKV DNAemia in kidney transplant recipients is a reasonable and safe approach. Younger age, female sex, higher initial viral load, and development of de novo donor-specific antibody (DSA) are characteristics observed more frequently in patients with rejection.
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Cell Biology
Peijun Li, Luyao Li, Binyuan Yu, Xinye Wang, Qi Wang, Jingjing Lin, Yihui Zheng, Jinjin Zhu, Minzhi He, Zhaonan Xia, Mengjing Tu, Judy S. Liu, Zhenlang Lin, Xiaoqin Fu
Summary: Mutations in the DCX gene cause human cortical malformations, affecting neurite length and distribution of cellular proteins. The absence of DCX leads to changes in the Golgi apparatus elongation process and alters the distribution of CLASP2, dynein, and JIP3 in neurons.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Otorhinolaryngology
Norio Kondo, Takahito Moriyama, Mayako Tachikawa, Erika Tomita, Ai Hattori, Yukie Yamamura, Manabu Nonaka
AURIS NASUS LARYNX
(2019)
Article
Urology & Nephrology
Takahiro Kamiyama, Takahito Moriyama, Saeko Kumon, Kazunori Karasawa, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Urology & Nephrology
Marie Nakano, Kazunori Karasawa, Takahito Moriyama, Keiko Uchida, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Medicine, General & Internal
Hiroshi Kataoka, Toshio Mochizuki, Taro Akihisa, Kentaro Kawasoe, Keiko Kawachi, Shiho Makabe, Anri Sawada, Shun Manabe, Masayo Sato, Nobuyuki Amemiya, Michihiro Mitobe, Takafumi Akanuma, Yasuko Ito, Takahiro Inoue, Tomo Suzuki, Katsuomi Matsui, Takahito Moriyama, Shigeru Horita, Mamiko Ohara, Kazuho Honda, Kosaku Nitta
Article
Urology & Nephrology
Takahito Moriyama
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Correction
Urology & Nephrology
Marie Nakano, Kazunori Karasawa, Takahito Moriyama, Keiko Uchida, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Urology & Nephrology
Yoei Miyabe, Kazunori Karasawa, Tomo Takabe, Shota Ogura, Naoko Sugiura, Mizuki Kyoda, Wataru Ono, Kenichi Akiyama, Nobue Tanaka, Takahito Moriyama, Norio Hanafusa, Keiko Uchida, Ken Tuchiya, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Article
Urology & Nephrology
Saeko Kumon, Takahito Moriyama, Takahiro Kamiyama, Kazunori Karasawa, Kosaku Nitta
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Letter
Immunology
Kazunori Karasawa, Shota Ogura, Yoei Miyabe, Kenichi Akiyama, Kosaku Nitta, Takahito Moriyama
CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Takahito Moriyama, Kazunori Karasawa, Yoei Miyabe, Kenichi Akiyama, Shota Ogura, Tomo Takabe, Naoko Sugiura, Momoko Seki, Yuko Iwabuchi, Keiko Uchida, Kosaku Nitta
SCIENTIFIC REPORTS
(2020)
Article
Urology & Nephrology
Takahito Moriyama, Hiroshi Kataoka, Kosaku Nitta, Keita Hirano, Keiichi Matsuzaki, Takashi Yasuda, Yoshinari Yasuda, Kentaro Koike, Shoichi Maruyama, Takashi Yokoo, Seiichi Matsuo, Tetsuya Kawamura, Yusuke Suzuki
Summary: This study suggests that the number of steroid pulses does not affect renal outcomes in IgA nephropathy patients with mild proteinuria and good renal function undergoing steroid pulse therapy with tonsillectomy. Treatment adaptation and protocols, such as the number of steroid pulses, should be tailored to individual patient backgrounds.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
William E. Hughes, Joe Hockenberry, Bradley Miller, Andrey Sorokin, Andreas M. Beyer
Summary: This study demonstrates that modulation of p66Shc signaling impairs cerebral artery myogenic tone in a low renin model of hypertension, but this effect depends on the genetic background as modulated p66Shc signaling in Sprague-Dawley rats does not impair cerebral artery myogenic tone.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bradley Miller, Kevin Regner, Andrey Sorokin
Summary: Renal ischemia-reperfusion injury is a major cause of acute kidney injury, and p66Shc adaptor protein plays an important role in this process. However, this study found that p66Shc expression or its signaling did not contribute to renal damage in a rat model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Urology & Nephrology
Takahito Moriyama, Kazunori Karasawa, Fumio Hasegawa, Keiko Uchida, Kosaku Nitta
AMERICAN JOURNAL OF NEPHROLOGY
(2019)
Article
Physiology
Yoei Miyabe, Sachiko Sekiya, Naoko Sugiura, Masatoshi Oka, Kazunori Karasawa, Takahito Moriyama, Kosaku Nitta, Tatsuya Shimizu
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Virology
Naiqing Xu, Xinen Tang, Xin Wang, Miao Cai, Xiaowen Liu, Xiaolong Lu, Shunlin Hu, Min Gu, Jiao Hu, Ruyi Gao, Kaituo Liu, Yu Chen, Xiufan Liu, Xiaoquan Wang
Summary: This study found that the H9N2 subtype avian influenza virus has a high airborne transmissibility, while the H7N9 virus does not. The Hemagglutinin protein of the H9N2 virus was found to play a key role in replication, stability, and airborne transmission.
Article
Virology
Samar S. Ewies, Sabry M. Tamam, Ahmed S. Abdel-Moneim, Sherin R. Rouby
Summary: Contagious ecthyma (CE) is a highly contagious viral disease of sheep and goats worldwide. The study provided a clinical description of CE and screened for genetic variation in the B2L gene. Infected sheep exhibited anorexia and oral lesions, while inoculated chicken embryos showed pock lesions. The B2L gene was successfully amplified and found to be highly conserved.
Article
Virology
Yigal Farnoushi, Dan Heller, Avishai Lublin
Summary: In recent years, new variants of avian reovirus (ARV) have caused a variety of symptoms in chickens worldwide, including viral arthritis/tenosynovitis. This study analyzed emerging ARV variants in Israel and found significant genetic diversity. Most ARV isolates in Israel belonged to genotypic cluster 5 (GC5). The study suggests that Israel has not experienced the emergence of new ARV variants since the introduction of the live vaccine (ISR-7585), but ongoing monitoring is needed due to the continuous emergence of ARV variants.
Article
Virology
Shigeru Tajima, Michiyo Kataoka, Yuki Takamatsu, Hideki Ebihara, Chang-Kweng Lim
Summary: Yokose virus (YOKV), a bat-associated flavivirus, was found to replicate at a slower rate in mosquito cells compared to other mosquito-borne flaviviruses. Specific nucleotide mutations in the virus were identified to enhance its proliferation ability in mosquito cells.
Article
Virology
Alejandra Borjabad, Baojun Dong, Wei Chao, David J. Volsky, Mary Jane Potash
Summary: This study investigated HIV brain disease using a mouse model, and found that poly I:C can reverse associated cognitive impairment and reduce virus burden. The results also revealed transcriptional changes related to neuronal function and innate immune responses.
Article
Virology
Ching-Hung Lin, Feng-Cheng Hsieh, Meilin Wang, Chieh Hsu, Hsuan-Wei Hsu, Chun-Chun Yang, Cheng-Yao Yang, Hung-Yi Wu
Summary: This study demonstrates that the synthesis of coronavirus subgenomic mRNA is not solely determined by the sequence homology between the leader TRS and TRS-B, but also by the disassociation of the coronavirus polymerase from the viral genome. This finding provides a new insight into the transcription mechanism of coronaviruses.
Article
Virology
Nicholas S. Kron, Benjamin W. Neuman, Sathish Kumar, Patricia L. Blackwelder, Dayana Vidal, Delphina Z. Walker-Phelan, Patrick D. I. Gibbs, Lynne A. Fieber, Michael C. Schmale
Summary: Two recent studies documented the genome of a novel virus in marine animals, finding that the virus is widespread in apparently healthy animals but not highly expressed in neurons. The studies also identified viral replication factories and high levels of defective genomes in chronically infected animals.
Article
Virology
Andrew M. Ramey, Laura C. Scott, Christina A. Ahlstrom, Evan J. Buck, Alison R. Williams, Mia Kim Torchetti, David E. Stallknecht, Rebecca L. Poulson
Summary: We successfully detected and characterized highly pathogenic avian influenza viruses in hunter-harvested wild waterfowl samples from western Alaska. Genomic analysis revealed three independent viral introductions into Alaska. Our findings demonstrate the utility and potential limitations of using molecular processing approaches directly on original swab samples for viral research and monitoring.
Article
Virology
Ting Gong, Dongdong Wu, Yongzhi Feng, Xing Liu, Qi Gao, Xiaoyu Zheng, Zebu Song, Heng Wang, Guihong Zhang, Lang Gong
Summary: This study discovered that quercetin can inhibit PEDV replication both in vivo and in vitro, and alleviate the clinical symptoms and intestinal injury caused by the virus. This provides a new direction for the development of PED antiviral drugs.
Article
Virology
Min Zhu, Hao Zeng, Jianqiao He, Yaohui Zhu, Pingping Wang, Jianing Guo, Jinfan Guo, Huabo Zhou, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Ying Chen
Summary: The reassortment between avian H9N2 and Eurasian avian-like (EA) H1N1 viruses may have potentially changed from avian-to-mammals adaptation. This study found that the introduction of EA H1N1 internal genes into H9N2 virus restored the replication capability and resulted in extreme virulence in some cases. This raises new concerns for public health due to the possible coexistence of H9N2 and EA H1N1 viruses in dogs.
