Article
Engineering, Biomedical
Sejal Patwardhan, Pratiksha Mahadik, Omshree Shetty, Shamik Sen
Summary: Exosomes play a significant role in breast cancer invasiveness triggered by ECM stiffness. High ECM stiffness promotes exosome secretion in a YAP/TAZ pathway-dependent manner, leading to changes in cell morphology, adhesion, and protrusion dynamics that enhance cell motility and invasion. Exosomes from stiff ECM cultures exhibit enrichment of cell adhesion and migration proteins, with thrombospondin-1 identified as a prospective regulator of stiffness-dependent cancer invasion mediated by exosomal communication.
Article
Medicine, General & Internal
Tokuko Hosoya, Goshi Oda, Tsuyoshi Nakagawa, Iichiroh Onishi, Tadashi Hosoya, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetake
Summary: The study found that the levels of DCN in plasma varied at different pathological stages in breast cancer patients, suggesting it could be a biomarker for advanced-stage patients. The results indicate that DCN plays an important regulatory role in the development of breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Katrin Raute, Juliane Strietz, Maria Alejandra Parigiani, Geoffroy Andrieux, Oliver S. Thomas, Klaus M. Kistner, Marina Zintchenko, Peter Aichele, Maike Hofmann, Houjiang Zhou, Wilfried Weber, Melanie Boerries, Mahima Swamy, Jochen Maurer, Susana Minguet
Summary: There is currently no targeted therapy for patients with triple-negative breast cancer (TNBC). TNBC is enriched in breast cancer stem cells (BCSC), which play a key role in metastasis, chemoresistance, relapse, and mortality. y8 T cells hold great potential in immuno-therapy against cancer and might provide an approach to therapeutically target TNBC.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Xin Li, Tuying Yong, Zhaohan Wei, Nana Bie, Xiaoqiong Zhang, Guiting Zhan, Jianye Li, Jiaqi Qin, Jingjing Yu, Bixiang Zhang, Lu Gan, Xiangliang Yang
Summary: The study demonstrates that co-delivery of indocyanine green and calcipotriol using tumor cell-derived microparticles can enhance the efficacy of photothermal therapy by remodeling the tumor extracellular matrix and improving anti-tumor immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Stefania D'Agostino, Lucia Tombolan, Mattia Saggioro, Chiara Frasson, Elena Rampazzo, Stefania Pellegrini, Francesca Favaretto, Carlo Biz, Pietro Ruggieri, Piergiorgio Gamba, Paolo Bonvini, Sanja Aveic, Roberto Giovannoni, Michela Pozzobon
Summary: The study demonstrates that unlike epithelial cancers, rhabdomyosarcoma (RMS) cells play a direct role in remodeling their own ECM and are less dependent on support from cancer-associated fibroblasts (CAFs). In both 2D and 3D models, the rate of interaction between RMS cells and fibroblasts is significantly lower, indicating a reduced reliance on CAFs for tumor growth.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Sarah Theresa Boyle
Summary: The tumor microenvironment, influenced by cancer cells, plays a pivotal role in promoting tumor growth through biochemical signaling, extracellular matrix remodeling, vascular network formation, and cell-stroma interaction. Hormone receptor-mediated signaling in breast cancer not only affects cancer cell proliferation and invasiveness, but also impacts the composition of the microenvironment. Understanding the associations between hormone receptor profiles and the microenvironment is crucial for developing effective therapies.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2023)
Article
Oncology
Santoshi Muppala, Roy Xiao, Jasmine Gajeton, Irene Krukovets, Dmitriy Verbovetskiy, Olga Stenina-Adognravi
Summary: Inflammation plays a key role in tumor growth and cancer aggressiveness. The protein thrombospondin-4 (TSP-4) has been identified as a mediator of breast cancer inflammation and growth, regulating TAM infiltration and inflammatory signaling in response to high glucose and TGF-beta. Targeting TSP-4 may offer new therapeutic opportunities for breast cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Yi Li, Changyuan Wang, Ting Huang, Xijie Yu, Bole Tian
Summary: Breast cancer deaths are primarily caused by metastasis. There are several treatment options, but limited options for preventing or inhibiting breast tumor metastases. Studies have focused on the importance of the tumor microenvironment (TME) in metastasis of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Vistnes, Pugazendhi Murugan Erusappan, Athiramol Sasi, Einar Sjaastad Norden, Kaja Knudsen Bergo, Andreas Romaine, Ida Gjervold Lunde, Lili Zhang, Maria Belland Olsen, Jonas Ogaard, Cathrine Rein Carlson, Christian Hjorth Wang, Jon Riise, Christen Peder Dahl, Arnt Eltvedt Fiane, Ida Marie Hauge-Iversen, Emil Espe, Arne Olav Melleby, Theis Tonnessen, Jan Magnus Aronsen, Ivar Sjaastad, Geir Christensen
Summary: This study aimed to explore the feasibility of using ADAMTS4 enzyme as a therapeutic target for heart failure and cardiac fibrosis. By using an ADAMTS4 inhibitor in rats with cardiac pressure overload, it was found that the inhibitor significantly improved cardiac function and reduced collagen accumulation. The study suggests that targeting ADAMTS4 may improve heart failure treatment through a novel cleavage mechanism that controls TGF-beta availability.
CARDIOVASCULAR RESEARCH
(2023)
Review
Oncology
Richard P. Tucker, Martin Degen
Summary: Tumor microenvironment (TME) plays a crucial role in tumor progression and provides potential targets for anti-cancer therapy. The tenascin family, especially tenascin-C and tenascin-W, shows promise as diagnostic and targetable molecules for cancer treatment purposes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shelby A. Fertal, Johanna E. Poterala, Suzanne M. Ponik, Kari B. Wisinski
Summary: This review summarizes recent outcomes from clinical trials with new agents for metastatic triple-negative breast cancer, focusing on immunotherapies targeting the PD-1/PD-L1 pathway and antibody-drug conjugates. The heterogeneity of triple-negative breast cancer leads to therapy resistance and poor patient outcome. The review also discusses the impact of the tumor microenvironment on the effectiveness of these therapies and highlights the need to develop novel stromal-targeted therapeutics.
Review
Oncology
Rocio Castillo-Sanchez, Ander Churruca-Schuind, Mileidy Martinez-Ival, Eduardo Perez Salazar
Summary: In breast cancer, tumor cells and cancer-associated fibroblasts communicate through extracellular vesicles, which play a critical role in the development and prognosis of breast cancer.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Multidisciplinary Sciences
Elina A. Pietilae, Jordi Gonzalez-Molina, Lidia Moyano-Galceran, Sanaz Jamalzadeh, Kaiyang Zhang, Laura Lehtinen, S. Pauliina Turunen, Tomas A. Martins, Okan Gultekin, Tarja Lamminen, Katja Kaipio, Ulrika Joneborg, Johanna Hynninen, Sakari Hietanen, Seija Grenman, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpen, Joseph W. Carlson, Kaisa Lehti
Summary: The study reveals that platinum chemotherapy enhances resistance by changing cancer cell adhesion signaling and ECM. The heterogeneity of fibrotic ECM in primary tumors and metastatic sites of HGSC before and after chemotherapy provides insights into cancer aggressiveness and potential treatment strategies. The upregulation of COL6 in metastatic HGSCs post-chemotherapy contributes to resistance and relapse, highlighting the importance of targeting the ECM pathway for therapeutic intervention.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
S. Karlsson, H. Nystrom
Summary: This review focuses on the importance of the extracellular matrix (ECM) in the tumor microenvironment (TME) and its impact on tumor cell behavior and metastatic capability. The study also highlights the potential of ECM as a target for therapy and a source of novel biomarkers in cancer treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Urology & Nephrology
Arsalan Tariq, Amy E. McCart Reed, Andrew Morton, Sima Porten, Ian Vela, Elizabeth D. Williams, John W. Yaxley, Peter C. Black, Matthew J. Roberts
Summary: PSMA may be associated with pathological and survival outcomes in urothelial carcinoma (UC). PSMA PET imaging helps in detecting metastatic disease and evaluating response to systemic therapy. More research is needed to confirm these findings.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Oncology
Kekoolani S. Visan, Richard J. Lobb, Shu Wen Wen, Justin Bedo, Luize G. Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T. Simpson, Amy E. McCart Reed, Sarah J. Everitt, Michael P. MacManus, Gunter Hartel, Carlos Salomon, Sunil R. Lakhani, David Fielding, Andreas Moeller
Summary: Lung cancer is a leading cause of cancer-related death worldwide and has low survival rates due to lack of early detection. A study on a lung cancer biomarker based on a simple blood test shows promising advantages for diagnostic assessment. The study identifies a specific micro-RNA, miR-3182, as a potential biomarker for lung cancer diagnosis that can be detected in the blood.
Article
Oncology
Jodi M. Saunus, Xavier M. De Luca, Korinne Northwood, Ashwini Raghavendra, Alexander Hasson, Amy E. McCart Reed, Malcolm Lim, Samir Lal, A. Cristina Vargas, Jamie R. Kutasovic, Andrew J. Dalley, Mariska Miranda, Emarene Kalaw, Priyakshi Kalita-de Croft, Irma Gresshoff, Fares Al-Ejeh, Julia M. W. Gee, Chris Ormandy, Kum Kum Khanna, Jonathan Beesley, Georgia Chenevix-Trench, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Dan V. Nicolau, Peter T. Simpson, Sunil R. Lakhani
Summary: This study reveals the relevance of SOX10 gene in triple-negative breast cancer (TNBC) and its role in the intratumoral heterogeneity. The researchers found that the reprogramming of SOX10 is associated with genome-wide promoter methylation loss, leading to a more primitive phenotype in TNBC.
Article
Multidisciplinary Sciences
Malcolm Lim, Nicholas Fletcher, Amy McCart Reed, Melanie Flint, Kristofer Thurecht, Jodi Saunus, Sunil R. Lakhani
Summary: Brain metastasis is a significant cause of morbidity and mortality in cancer patients, and animal models play a critical role in studying therapeutic interventions. Existing brain tumor xenografting methods lack consistency, and intracardiac injection can result in unintended extracranial growth. This study presents a mouse model of brain metastasis generated by internal carotid artery injection, which produces consistent intracranial tumors.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Editorial Material
Oncology
Monica Fedele, Amy McCart Reed
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
P. Ramarao-Milne, O. Kondrashova, A. -M. Patch, K. Nones, L. T. Koufariotis, F. Newell, V. Addala, V. Lakis, O. Holmes, C. Leonard, S. Wood, Q. Xu, P. Mukhopadhyay, M. M. Naeini, D. Steinfort, J. P. Williamson, M. Bint, C. Pahoff, P. T. Nguyen, S. Twaddell, D. Arnold, C. Grainge, F. Basirzadeh, D. Fielding, A. J. Dalley, H. Chittoory, P. T. Simpson, L. G. Aoude, V. F. Bonazzi, K. Patel, A. P. Barbour, D. A. Fennell, B. W. Robinson, J. Creaney, G. Hollway, J. V. Pearson, N. Waddell
Summary: This study explored drug repurposing opportunities using the Cancer Genome Interpreter and whole-genome sequencing. The ability of different sequencing methods, including whole-exome sequencing and comprehensive sequencing panels, to detect actionable mutations, tumor mutation burden, and microsatellite instability was compared. The results revealed shared biomarkers among different solid tumor types, with comprehensive panels identifying the majority of actionable mutations and whole-genome sequencing detecting more candidate actionable mutations.
Review
Cell Biology
A. Sokolova, K. J. Johnstone, A. E. McCart Reed, P. T. Simpson, S. R. Lakhani
Summary: Hereditary factors, including pathogenic variants in genes such as BRCA1, BRCA2, ATM, CHEK2, etc., play a significant role in breast cancer risk. Polygenic risk, which results from carrying multiple low-penetrance breast cancer susceptibility alleles, also contributes to the risk. This review provides an overview of established breast cancer susceptibility genes, breast cancer predisposition syndromes, and discusses the implications of molecular testing and therapy in hereditary breast cancer.
Review
Oncology
Vaibhavi Joshi, Sunil R. Lakhani, Amy E. McCart E. Reed
Summary: N-myc downregulated gene-1 (NDRG1) has been reported to have diverse roles in cancer, serving as either a metastasis suppressor, a biomarker of poor outcome, or a facilitator of disease progression. Its functions in cancer are context-dependent and pleiotropic, with its effects in breast cancer varying depending on post-translational modifications and subcellular localization.
Article
Oncology
David I. Fielding, Andrew J. Dalley, Mahendra Singh, Lakshmy Nandakumar, Vanessa Lakis, Haarika Chittoory, David Fairbairn, Ann-Marie Patch, Stephen H. Kazakoff, Kaltin Ferguson, Farzad Bashirzadeh, Michael Bint, Carl Pahoff, Jung Hwa Son, Alan Hodgson, Sowmya Sharma, Nicola Waddell, Sunil R. Lakhani, Gunter Hartel, Katia Nones, Peter T. Simpson
Summary: Microscopy of Diff-Quik smears can predict DNA yield and be used for molecular diagnostics. This method can be a better alternative to traditional cell block testing.
CANCER CYTOPATHOLOGY
(2023)
Article
Cell Biology
Heather Thorne, Lisa Devereux, Jason Li, Kathryn Alsop, Liz Christie, Courtney T. van Geelen, Nikki Burdett, Kathleen Pishas, Noel Woodford, Jodie Leditschke, Mohamed H. M. A. Izzath, Kate Strachan, Gregory Young, Rufaro D. Jaravaza, Mohammed S. Madadin, Melanie Archer, Joanna Glengarry, Linda Iles, Ajith Rathnaweera, Clare Hampson, Khamis Almazrooei, Michael Burke, Pradeep Bandara, David Ranson, Essa Saeedi, Orla McNally, Linda Mileshkin, Anne Hamilton, Sumitra Ananda, George Au-Yeung, Yoland Antill, Shahneen Sandhu, Peter Savas, Prudence A. Francis, Stephen Luen, Sherene Loi, Ross Jennens, Clare Scott, Kate Moodie, Margaret Cummings, Andrew Reid, Amy McCart Reed, David Bowtell, Sunil R. Lakhani, Stephen Fox
Summary: This study aims to examine the metastatic patterns of breast, ovarian, and prostate cancer in germline BRCA1/2 mutation carriers and non-carriers through a rapid autopsy program. It found significant differences in the patterns of metastases in breast and ovarian cancer between BRCA1/2 carriers and non-carriers, while no significant differences were observed in prostate cancer. The findings have implications for clinical diagnostic imaging in monitoring metastases.
Letter
Medicine, General & Internal
Amy E. McCart Reed, Georgina Hollway, Sunil Lakhani
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Oncology
Andrew Causer, Xiao Tan, Xuehan Lu, Philip Moseley, Siok M. Teoh, Natalie Molotkov, Margaret McGrath, Taehyun Kim, Peter T. Simpson, Christopher Perry, Ian H. Frazer, Benedict Panizza, Rahul Ladwa, Quan Nguyen, Jazmina L. Gonzalez-Cruz
Summary: In this study, advanced integrative spatial proteogenomic analysis was used to investigate the role of spatial determinants in cancer therapy outcomes. The researchers found that spatial transcriptomics successfully detected tumor cells and allowed for the investigation of phenotypic traits. Additionally, spatial proteomic imaging resolved the profiling of tumor infiltrating immune cells. The study also discovered clinically relevant alternative medicines based on their interaction with their matching ligand-receptor. Importantly, the researchers found that new tumors were not the product of immune checkpoint inhibitor (ICI) resistance but rather of a dose reduction due to complications.
NPJ PRECISION ONCOLOGY
(2023)
Meeting Abstract
Cell Biology
A. Stacey, P. Simpson, A. McCart-Reed, M. Cummings