Article
Oncology
Louise Rethacker, Maxime Boy, Valeria Bisio, France Roussin, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Christine Sedlik, Eliane Piaggio, Antoine Toubert, Nicolas Dulphy, Anne Caignard
Summary: Innate lymphoid cells (ILCs), including NK cells and ILC3, play important roles in tissue immune homeostasis and tumor surveillance. In human lymph nodes, NK cells and ILC3s are the prominent subpopulations. However, in tumor-draining lymph nodes and breast cancer tumors, NK cells are more abundant while proportions of ILC3 subsets are low. The local tumor microenvironment inhibits NK cell functions through downregulation of a specific receptor, but cytokine stimulation can restore their functionality.
Article
Immunology
Pin-Ji Lei, Ethel R. Pereira, Patrik Andersson, Zohreh Amoozgar, Jan Willem Van Wijnbergen, Meghan J. O'Melia, Hengbo Zhou, Sampurna Chatterjee, William W. Ho, Jessica M. Posada, Ashwin S. Kumar, Satoru Morita, Lutz Menzel, Charlie Chung, Ilgin Ergin, Dennis Jones, Peigen Huang, Semir Beyaz, Timothy P. Padera
Summary: Lei et al. uncover that a subpopulation of breast cancer cells in the lymph node express MHC-II without costimulatory molecules, resulting in the expansion of immunosuppressive regulatory T cells. Tumor-draining lymph nodes play a crucial role in generating tumor antigen-specific T cells and effective anticancer immune responses. However, these lymph nodes are frequently the site of metastasis, leading to immune suppression and poorer outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Xue-Qiang Zhu, Pei Lu, Zhong-Lin Xu, Qiang Zhou, Jun Zhang, Zhi-Biao Wang, Feng Wu
Summary: Previous studies have shown that HIFU ablation can trigger an antitumor immune response. This study revealed a significant enhancement of immune response in TDLNs, especially in the ALNs, after HIFU treatment for breast cancer. HIFU significantly increased T cell, activated CTLs and NK cell populations in the TDLNs.
Review
Oncology
Tianze Yu, Yuexin Lu, Jianwen Fang, Xiaocong Jiang, Yue Lu, Jingyan Zheng, Xi Shang, Haixing Shen, Peifen Fu
Summary: This review discusses the recent progress in chimeric antigen receptor (CAR)-based immunotherapy for breast cancer treatment, including targeting tumor antigens, considering breast cancer subtypes, assessing the tumor microenvironment, and exploring combinatorial therapies. The review also highlights the contribution of China in CAR-based immunotherapies for breast cancer through preclinical studies and clinical trials, providing inspiration for further research.
Article
Oncology
Hans Raskov, Adile Orhan, Ali Salanti, Shruti Gaggar, Ismail Gogenur
Summary: NK cells play a crucial role in cancer treatment by recognizing and killing transformed cells, potentially improving treatment outcomes. Current research focuses on the development of immunotherapeutic approaches, including immune checkpoint inhibitors and adoptive cell transfer using T cells with chimeric antigen receptors to enhance immune function.
Article
Multidisciplinary Sciences
Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stuerzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Le Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin, Michaela Mueller-Trutwin
Summary: NK cells play a critical role in controlling SIV infection in the natural host through terminal differentiation and enhanced MHC-E-dependent activity, contributing to the understanding of NK cell adaptation to viral infection and potential therapies.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Liangtao Zhao, Wenyuan Shi, Fangfang Hu, Xujun Song, Zhangjun Cheng, Jiahua Zhou
Summary: Oral ingestion of microplastics increases liver weight, alters the immune cell populations and inflammatory cytokine expression, especially affecting the infiltration of natural killer cells and macrophages. These effects are regulated via the NF-κB pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Immunology
Kavita Rawat, Anita Tewari, Xin Li, Arlind B. B. Mara, William T. T. King, Sophie L. L. Gibbings, Chinaza F. F. Nnam, Fred W. W. Kolling, Bart N. N. Lambrecht, Claudia V. V. Jakubzick
Summary: Dendritic cells and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes in a CCR7-dependent manner. It is unclear how monocytes reach the lymph nodes since only migratory dendritic cells express this chemokine receptor.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Biomedical
Zhenghu Chen, Zihua Zeng, Quanyuan Wan, Xiaohui Liu, Jianjun Qi, Youli Zu
Summary: This study demonstrates a novel immunotherapeutic approach for targeting triple-negative breast cancer (TNBC) using aptamer-engineered NK cells. The synthetic aptamer probes selectively target TNBC cell lines and trigger apoptosis and death of cultured TNBC cells. Systemic administration of aptamer-engineered NK cells inhibits lung metastasis in mice harboring TNBC xenografts.
Article
Pharmacology & Pharmacy
Sepide Hossenipour Khodaei, Shahbaz Sabetnam, Hojjatollah Nozad Charoudeh, Khadijeh Dizaji Asl, Ali Rafat, Zeinab Mazloumi
Summary: This study demonstrated that inhibiting mitochondria with Tigecycline can enhance the cytotoxicity of NK cells against triple-negative breast cancer (TNBC) cells and promote apoptosis in TNBC cells. This suggests that mitochondria inhibition may improve the function of NK cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Lily Chan, Yeganeh Mehrani, Geoffrey A. A. Wood, Byram W. W. Bridle, Khalil Karimi
Summary: DC-based cancer vaccines can recruit neutrophils to lymph nodes and increase the number of NK cells, enhancing anti-tumor immune responses. Depletion of neutrophils results in decreased NK cell numbers, while CD8+ T cell population remains unaffected. Targeting neutrophils may offer innovative strategies to enhance the clinical efficacy of DC vaccines.
Article
Chemistry, Multidisciplinary
Klaudia Kvakova, Martin Ondra, Jiri Schimer, Milos Petrik, Zbynek Novy, Helena Raabova, Marian Hajduch, Petr Cigler
Summary: This study developed a sensitive approach using fluorescent nanodiamonds for visualizing tumor-draining sentinel lymph nodes. The results showed that the modified nanodiamonds have potential as a tracer for cancer diagnostics and fluorescence-guided surgery.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Tatiana Michel, Markus Ollert, Jacques Zimmer
Summary: Despite the challenges in cancer treatment, immunotherapy based on NK cells is considered to be one of the most promising options and has already shown success in clinical settings. This review highlights the different possibilities and mechanisms of NK cells in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hoon Sik Choi, Young Shin Ko, Hana Jin, Ki Mun Kang, In Bong Ha, Hojin Jeong, Jeong-hee Lee, Bae Kwon Jeong, Hye Jung Kim
Summary: In this study, the anticancer effect of the combination of mebendazole (MBZ) and radiotherapy (RT) was evaluated in triple-negative breast cancer (TNBC) cells. The results showed that the combined treatment increased the anticancer effect of RT without additional toxicity. Furthermore, the combination therapy blocked cell cycle progression, induced DNA double-strand breaks, and promoted NK cell-mediated cytotoxicity in TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tarek Hashem, Ahmed Abdelmoez, Ahmed Mohamed Rozeka, Hazem Abdelazeem
Summary: IMLNs are frequently overlooked by clinicians and proper efforts should be made to detect them. Malignant IMLNs are associated with advanced pathological features and should be removed during surgery. Further research on the prevalence and characteristics of IMLNs in breast cancer patients is warranted.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Daniel H. Ahn, Pedro Luiz Serrano Uson Junior, Peter Masci, Heidi Kosiorek, Thorvardur R. Halfdanarson, Kabir Mody, Hani Babiker, Thomas DeLeon, Mohamad Bassam Sonbol, Gregory Gores, Rory Smoot, Tanios Bekaii-Saab, Amit Mahipal, Aaron Mansfield, Nguyen H. Tran, Joleen M. Hubbard, Mitesh J. Borad
Summary: Ponatinib as a single agent in treating BTC with FGFR alterations showed limited clinical activity but was tolerable. The study provides valuable information for the further development of ponatinib in BTC treatment.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Oncology
S. Peters, A. Scherpereel, R. Cornelissen, Y. Oulkhouir, L. Greillier, M. A. Kaplan, T. Talbot, I Monnet, S. Hiret, P. Baas, A. K. Nowak, N. Fujimoto, A. S. Tsao, A. S. Mansfield, S. Popat, X. Zhang, N. Hu, D. Balli, T. Spires, G. Zalcman
Summary: In patients with unresectable malignant pleural mesothelioma, first-line nivolumab plus ipilimumab showed continued long-term survival benefit over chemotherapy with a manageable safety profile, based on 3 years of follow-up data.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Arun Kanakkanthara, Xiaonan Hou, Thomas L. Ekstrom, Valentina Zanfagnin, Amelia M. Huehls, Rebecca L. Kelly, Husheng Ding, Melissa C. Larson, George Vasmatzis, Ann L. Oberg, Scott H. Kaufmann, Aaron S. Mansfield, S. John Weroha, Larry M. Karnitz
Article
Gastroenterology & Hepatology
Pedro Luiz Serrano Uson, Thomas T. DeLeon, James M. Bogenberger, Rish K. Pai, Heidi E. Kosiorek, Jun Yin, Daniel H. Ahn, Mohammad Bassam Sonbol, Tanios Bekaii-Saab, Aaron S. Mansfield, Kenneth Buetow, Gregory J. Gores, Rory Smoot, George Vasmatzis, Benjamin R. Kipp, Amit Mahipal, Alexander T. Baker, Hani Babiker, Oumar Barro, Chelsae Dumbauld, Yumei Zhou, Faaiq N. Aslam, Michael Barrett, Bertram Jacobs, Nathalie Meurice, Mansi Arora, Joachim Petit, Natalie Elliott, Bolni Nagalo, Marcela A. Salomao, Mitesh J. Borad
Summary: Immunohistochemistry staining with two antibodies against FGFR2 showed high accuracy and specificity, but only moderate sensitivity, for detecting FGFR2 genomic alterations in cholangiocarcinoma. However, there were no significant differences in clinical outcomes including overall survival, progression-free survival, and time-to-tumor recurrence between patients with positive or negative FGFR2 staining in a median follow-up of 72 months.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Meeting Abstract
Oncology
Patrick Walsh McGarrah, Jennifer Gile, Alex John Liu, Aaron Scott Mansfield, Konstantinos Leventakos, Aakash Desai, Sri Harsha Tella, Bassam Bassam Sonbol, Jason S. Starr, Timothy J. Hobday, Thorvardur Ragnar Halfdanarson
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Anne S. Tsao, Harvey Pass, Andreas Rimner, Aaron S. Mansfield
Summary: Malignant pleural mesothelioma (MPM) is a rare malignancy with limited treatment options. Recent advances have led to changes in treatment standards, including the use of a novel biomedical device in combination with platinum-pemetrexed and the inclusion of immunotherapy as a frontline treatment option. Proper identification of the MPM histology is crucial in determining the optimal treatment plan. Immunotherapy can benefit all MPM patients and should be considered at some point during treatment. Ongoing research is focusing on defining frontline therapy in the unresectable setting and addressing immunotherapy refractory cases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ti Wen, Whitney Barham, Ying Li, Henan Zhang, Joanina K. Gicobi, Jacob B. Hirdler, Xin Liu, Hyoungjun Ham, Kodi E. Peterson Martinez, Fabrice Lucien, Roxane R. Lavoie, Hu Li, Cristina Correia, Dileep D. Monie, Zesheng An, Susan M. Harrington, Xiaosheng Wu, Ruifeng Guo, Roxana S. Dronca, Aaron S. Mansfield, Yiyi Yan, Svetomir N. Markovic, Sean S. Park, Jie Sun, Hong Qin, Minetta C. Liu, George Vasmatzis, Daniel D. Billadeau, Haidong Dong
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Anja C. Roden, Sagar Rakshit, Geoffrey B. Johnson, Sarah M. Jenkins, Aaron S. Mansfield
Summary: The expression of SSTR2 in neuroendocrine tumors and carcinomas plays a role in imaging studies and guiding therapy. In this study, SSTR2 expression in TET was correlated with 68Ga-DOTATATE PET/CT or 68Ga-DOTATATE PET/MR results and treatment outcome. The findings suggest that 68Ga-DOTATATE PET scans are useful in identifying TET patients who may be amenable to treatment with somatostatin analogues.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Oncology
Anuhya Kommalapati, Aaron S. Mansfield
Summary: The activity of KRAS inhibitors against brain metastases is not well studied. Recent preclinical models and preliminary data from the ongoing KRYSTAL-1 phase Ib clinical trial suggest that adagrasib (MRTX849) has the potential to penetrate the central nervous system and provide control of KRAS(G12C) brain metastases.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Daniel P. Wickland, Mark E. Sherman, Derek C. Radisky, Aaron S. Mansfield, Yan W. Asmann
Summary: In the United States, cancer disparities among Black and African American individuals are affected by genetic factors. This study compared the qualities of germline and tumor exomes between African and European patients in The Cancer Genome Atlas. The results showed that African patients had lower sequencing depth, leading to underdetection and lower quality of variants. Consideration of epidemiological factors is crucial for future genomics studies.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Farhad Kosari, Maria Disselhorst, Jun Yin, Tobias Peikert, Julia Udell, Sarah Johnson, James Smadbeck, Stephen Murphy, Alexa McCune, Giannoula Karagouga, Aakash Desai, Janet Schaefer-Klein, Mitesh J. Borad, John Cheville, George Vasmatzis, Paul Baas, Aaron S. Mansfield
Summary: This study found that the interaction between tumor junction burdens and antigen presentation gene sets in mesothelioma patients is associated with overall survival, providing further insight into the potential mechanisms of immunotherapy.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Letter
Oncology
Daniel P. Wickland, Mark E. Sherman, Derek C. Radisky, Aaron S. Mansfield, Yan W. Asmann
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Multidisciplinary Sciences
James M. Dolezal, Andrew Srisuwananukorn, Dmitry Karpeyev, Siddhi Ramesh, Sara Kochanny, Brittany Cody, Aaron S. Mansfield, Sagar Rakshit, Radhika Bansal, Melanie C. Bois, Aaron O. Bungum, Jefree J. Schulte, Everett E. Vokes, Marina Chiara Garassino, Aliya N. Husain, Alexander T. Pearson
Summary: A model's ability to express its own predictive uncertainty is crucial in maintaining clinical user confidence in real-world medical settings. This study presents a clinically-oriented approach to quantify uncertainty in cancer digital histopathology, using dropout to estimate uncertainty and establishing cutoffs for low- and high-confidence predictions based on threshold calculation on training data.
NATURE COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
A. Dimou, Y. -C. Lo, K. Halling, A. S. Mansfield
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Pedro Luiz Serrano Uson Junior, Umair Majeed, Jun Yin, Gehan Botrus, Mohamad Bassam Sonbol, Daniel H. Ahn, Jason S. Starr, Jeremy C. Jones, Hani Babiker, Samantha R. Inabinett, Natasha Wylie, Ashton W. R. Boyle, Tanios S. Bekaii-Saab, Gregory J. Gores, Rory Smoot, Michael Barrett, Bolni Nagalo, Nathalie Meurice, Natalie Elliott, Joachim Petit, Yumei Zhou, Mansi Arora, Chelsae Dumbauld, Oumar Barro, Alexander Baker, James Bogenberger, Kenneth Buetow, Aaron Mansfield, Kabir Mody, Mitesh J. Borad
Summary: This study aimed to evaluate the prognostic value of pretreatment circulating tumor DNA (ctDNA) in metastatic biliary tract cancers (BTCs) treated with platinum-based chemotherapy. The results showed that DCAF > 3% was associated with worse overall survival (OS). Stratifying DCAF into quartiles, DCAF > 10% was significantly related to worse progression-free survival (PFS) and OS. Each 1% increase in ctDNA was associated with a decrease in survival probabilities.
JCO PRECISION ONCOLOGY
(2022)