Journal
VIRCHOWS ARCHIV
Volume 456, Issue 2, Pages 141-151Publisher
SPRINGER
DOI: 10.1007/s00428-009-0774-2
Keywords
Gene expression profiling; Microarrays; Genomics; Bioinformatics; Tumor biology; Soft tissue tumors; Sarcomas; Biomarkers; Molecular pathology; Surgical pathology
Categories
Funding
- NLM NIH HHS [T15 LM007033] Funding Source: Medline
Ask authors/readers for more resources
Soft tissue sarcomas are malignant neoplasms derived from mesenchymal tissues. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. In the past decade, gene expression profiling has been applied to sarcomas to facilitate understanding of sarcoma pathogenesis and to identify diagnostic, prognostic, and predictive markers. In this paper, we review this body of work and discuss how gene expression profiling has led to advancements in the understanding of sarcoma pathobiology, the identification of clinically useful biomarkers, and the refinement of sarcoma classification schemes. Lastly, we conclude with a discussion of strategies to further optimize the translation of gene expression data into a greater understanding of sarcoma pathogenesis and improved clinical outcomes for sarcoma patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available