Article
Immunology
Huijeong Ahn, Hansae Lee, Gilyoung Lee, Jeongho Park, Haan-Woo Sung, Eunsong Lee, Geun-Shik Lee
Summary: The study found that parabens could disrupt Gram-negative pathogen infection through the inhibition of non-canonical inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
Summary: This study found that maltol can inhibit the activation of inflammasomes, thus reducing inflammation. By inhibiting ROS production and Casp1 activity, maltol exerts its anti-inflammatory effects.
Article
Pharmacology & Pharmacy
Judith Bockstiegel, Silas L. Wurnig, Jonas Engelhardt, Jana Enns, Finn K. Hansen, Guenther Weindl
Summary: The deficiency of HDAC6 does not affect the release of IL-1β mediated by NLRP3 in human immune cells, indicating that the inhibition of HDAC6 is not necessary for the function of the NLRP3 pathway. In addition, HDAC6 inhibitors have the potential to suppress inflammatory responses and inhibit the release of IL-1β by regulating Toll-like receptor (TLR) signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Geun-Shik Lee
Summary: Studies have shown that lower temperatures enhance the formation of MSU crystals and activation of the NLRP3 inflammasome, resulting in increased secretion of IL-1β. These findings suggest that hyperthermia therapy may reduce gout flaring.
Article
Biochemistry & Molecular Biology
Tomomi Kurane, Tetsuro Matsunaga, Tomoaki Ida, Kazuko Sawada, Akira Nishimura, Masayuki Fukui, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Sohkichi Matsumoto, Takaaki Akaike, Goro Matsuzaki, Giichi Takaesu
Summary: The study reveals the previously unrecognized role of GRIM-19 as an essential regulator of NLRP3 inflammasome and a molecular mechanism underlying Zmp1-mediated suppression of IL-1 beta production during mycobacterial infection.
Article
Biochemistry & Molecular Biology
Ines Vieira da Silva, Carlos Cardoso, Helios Martinez-Banaclocha, Angela Casini, Pablo Pelegrin, Graca Soveral
Summary: The study suggests that aquaporin AQP3 may be involved in NLRP3-inflammasome activation, affecting the production of inflammatory cytokines by regulating cell priming and cell swelling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg
Summary: Abnormal activation of the immune system is a known cause of lupus. Inhibiting the inflammasome and its downstream components has been shown to reduce disease severity in lupus mouse models. This study examines the effects of IL-1 beta loss on disease severity in a lupus-prone mouse model and identifies potential clinical relevance of TNF and IL-17 signaling pathways. Caution may be needed when inhibiting inflammasome or IL-1 beta signaling in SLE, especially in patients with renal involvement.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ching-Chun Yang, Chih-Hsing Wu, Ta-Chun Lin, Yi-Ning Cheng, Chin-Sung Chang, Kuo-Ting Lee, Pei-Jane Tsai, Yau-Sheng Tsai
Summary: The study reveals an additional anti-inflammatory role for PPAR gamma in suppressing NLRP3 inflammasome activation through interaction with NLRP3.
Article
Multidisciplinary Sciences
Fabian A. Fischer, Linda F. M. Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C. Kagan, Elena Di Daniel, Jelena S. Bezbradica
Summary: The activation of NLRP3 inflammasome is regulated by multiple mechanisms, including a posttranslational phospho-switch described in this study. This phospho-switch involves the protein phosphatase 2A (PP2A) as an ON switch and the kinases TANK-binding kinase 1 (TBK1) and I-kappa-B kinase epsilon (IKKe) as an OFF switch. Understanding these regulatory mechanisms could provide new insights for disease interventions related to NLRP3 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Manal Abdulaziz Binobead, Azhar Hamad Aldakhilallah, Sahar Abdulaziz Alsedairy, Laila Naif Al-Harbi, Wahidah H. Al-Qahtani, Ghedeir M. Alshammari
Summary: This study investigated the effects of a ketogenic diet on anthropometric indices, lipid profile, and the inhibition of NLRP3 inflammasome in obese women. The results showed that the ketogenic diet led to significant weight loss, reduced waist circumference and BHB levels, and decreased BMI and appetite. Cholesterol, triglycerides, and HDL-C slightly increased, while LDL-C and 1L-1 beta decreased significantly. The questionnaire results indicated improvements in various physical symptoms.
Article
Pharmacology & Pharmacy
Xiaoling Li, Yiming Liu, Chengyu Luo, Jinhui Tao
Summary: This study identified a potent P2X7R allosteric inhibitor that effectively reduced gouty joint inflammation by inhibiting NLRP3 inflammasome activation, suggesting a new direction in gout treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi
Summary: CAPS is an autoinflammatory syndrome caused by mutations of the NLRP3 gene, and mutated NLRP3 can form cryo-sensitive aggregates to promote inflammasome assembly, with IL-1β release influenced by mutated NLRP3 and Ca2+ playing a crucial role in inflammasome assembly.
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da
Summary: Pin1 regulates NLRP3 inflammasome activation through the p38 MAPK signaling pathway in mice, impacting shock mortality and organ damage. Lack of Pin1 reduces NLRP3 inflammasome activation and secretion of inflammatory cytokines, suggesting Pin1 as a potential target for treating inflammatory diseases such as septic shock.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ting-Yi Lin, Meng-Chun Tsai, Wei Tu, Hsin-Chih Yeh, Shu-Chi Wang, Shu-Pin Huang, Chia-Yang Li
Summary: The role of inflammasomes in cancer biology is not well understood, but research on NLRP3 could provide opportunities for discovering new therapeutic targets to prevent tumor expansion and achieve metastatic control.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yongjin Lee, Hanna Lee, Joohyeong Lee, Seung Tae Lee, Geun-Shik Lee, Eunsong Lee
Summary: Glucose supplementation in maturation medium with reduced NaCl concentration significantly improved oocyte maturation and embryonic development in pigs, regardless of the base medium used. Higher blastocyst formation was observed in oocytes matured in medium with 61.6 mM NaCl, indicating the importance of glucose supplementation in enhancing embryonic development through parthenogenesis, somatic cell nuclear transfer, and in vitro fertilization.
Article
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Seung-Ho Lee, Geun-Shik Lee
Summary: The study found that RGE and its saponins can inhibit the secretion of IL-1 beta in response to UV exposure in skin keratinocytes and macrophages, with RGE primarily interrupting the priming step in keratinocytes.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Environmental Sciences
Jaehyun Park, Jeeyoung Kim, Esther Kim, Woo Jin Kim, Sungho Won
Summary: Prenatal lead exposure was found to be associated with altered, gender-specific patterns of DNA methylation in Korean infants. In males, maternal blood lead level during early pregnancy was linked to 18 CpG sites, while a CpG site near the NBAS gene was associated during late pregnancy. No significant association was observed in females.
ENVIRONMENTAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Joohyeong Lee, Eunhye Kim, Seon-Ung Hwang, Lian Cai, Mirae Kim, Hyerin Choi, Dongjin Oh, Eunsong Lee, Sang-Hwan Hyun
Summary: The study showed that treatment with glucuronic acid and N-acetyl-D-glucosamine during porcine oocyte in vitro maturation can enhance oocyte diameter, perivitelline space thickness, reduce reactive oxygen species levels, improve gene expression, and enhance cortical granule reaction. This treatment also led to higher blastocyst rates in both chemically defined and complex media, indicating beneficial effects on early embryonic development after parthenogenesis and somatic cell nuclear transfer.
Article
Multidisciplinary Sciences
Sooim Sin, Hye-Mi Choi, Jiwon Lim, Jeeyoung Kim, So Hyeon Bak, Sun Shim Choi, Jinkyeong Park, Jin Hwa Lee, Yeon-Mok Oh, Mi Kyeong Lee, Brian D. Hobbs, Michael H. Cho, Edwin K. Silverman, Woo Jin Kim
Summary: This study investigated the genetic components of emphysema in a Korean population and identified multiple SNPs associated with emphysema severity. These candidate SNPs may provide insights into the genetic etiology of emphysema in Asian populations and further research and validation of the loci are needed for determining the genetic factors for the development of emphysema.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Jeongeun Kim, Jeongho Park, Seung Goo Kang, Sung-Il Yoon, Eunsong Lee, Geun-Shik Lee
Summary: NLRP3 inflammasome activation inhibits LCN2 secretion while inducing IL-1β in mouse macrophages. The inhibition of NLRP3 triggers on LCN2 secretion is caused by the inhibited transcription and translation of LCN2, suggesting a new linkage between inflammasome activation and LCN2 secretion in the innate immunity.
Article
Cell Biology
Huijeong Ahn, Gilyoung Lee, Geun-Shik Lee
Summary: Studies have shown that lower temperatures enhance the formation of MSU crystals and activation of the NLRP3 inflammasome, resulting in increased secretion of IL-1β. These findings suggest that hyperthermia therapy may reduce gout flaring.
Article
Immunology
Huijeong Ahn, Hansae Lee, Gilyoung Lee, Jeongho Park, Haan-Woo Sung, Eunsong Lee, Geun-Shik Lee
Summary: The study found that parabens could disrupt Gram-negative pathogen infection through the inhibition of non-canonical inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Yongjin Lee, Joohyeong Lee, Sang-Hwan Hyun, Geun-Shik Lee, Eunsong Lee
Summary: Using a medium with reduced NaCl enhances cytoplasmic maturation and embryonic development of pig oocytes.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Ah Ra Do, Do Yeon Ko, Jeeyoung Kim, So Hyeon Bak, Ki Yeol Lee, Dankyu Yoon, Chol Shin, Soriul Kim, Woo Jin Kim, Sungho Won
Summary: This study identified SNPs associated with airway wall thickening using a genome-wide association study. The results revealed a significant SNP near a gene involved in inhibiting epithelial-mesenchymal transition, as well as other SNPs related to airway inflammation and proliferation that influenced airway wall thickness.
Article
Biochemistry & Molecular Biology
Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
Summary: This study found that maltol can inhibit the activation of inflammasomes, thus reducing inflammation. By inhibiting ROS production and Casp1 activity, maltol exerts its anti-inflammatory effects.
Article
Agriculture, Dairy & Animal Science
Minji Kim, Ji-Eun Park, Yongjin Lee, Seung-Tae Lee, Geun-Shik Lee, Sang-Hwan Hyun, Eunsong Lee, Joohyeong Lee
Summary: This study investigated the effect of different growth factors and hormones on the in vitro maturation and developmental competence of oocytes derived from small antral follicles in pigs. It was found that insulin treatment during oocyte growth promotes nuclear maturation, embryonic development, and cumulus cell expansion. Insulin also enhances cytoplasmic maturation, reduces free radical content, and increases maturation-promoting factor activity.
Article
Veterinary Sciences
Ji-Young Jeong, Lian Cai, Mirae Kim, Hyerin Choi, Dongjin Oh, Ali Jawad, Sohee Kim, Haomiao Zheng, Eunsong Lee, Joohyeong Lee, Sang-Hwan Hyun
Summary: This study examined the effects of Ergothioneine (EGT) supplementation during in vitro maturation (IVM) on porcine oocyte maturation and subsequent embryonic development competence after in vitro fertilization (IVF). The results showed that EGT supplementation improved oocyte maturation and embryonic development by reducing oxidative stress in IVM oocytes.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Medicine, General & Internal
Jeongwon Heo, Da Hye Moon, Yoonki Hong, So Hyeon Bak, Jeeyoung Kim, Joo Hyun Park, Byoung-Doo Oh, Yu-Seop Kim, Woo Jin Kim
Summary: This study identified potential biomarkers for COPD diagnosis using word embedding, with Cyfra 21-1 showing promise for being a biomarker for emphysema. Further research is needed to confirm Cyfra 21-1 as a biomarker for COPD.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Respiratory System
Da Hye Moon, Jeeyoung Kim, Myoung Nam Lim, So Hyen Bak, Woo Jin Kim
Summary: The study found that telomere length was significantly lower in COPD patients compared to non-COPD patients, but no significant associations were found between telomere length and lung function, exacerbation, airway wall thickness, and emphysema index after adjusting for sex, age, and smoking status.
TUBERCULOSIS AND RESPIRATORY DISEASES
(2021)