Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

(2015) Yosua Adi Kristariyanto et al.   MOLECULAR CELL

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

(2015) Martin A. Michel et al.   MOLECULAR CELL

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate degradation by the proteasome: A single-molecule kinetic analysis

(2015) Y. Lu et al.   SCIENCE

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualizing an Ultra-Weak Protein-Protein Interaction in Phosphorylation Signaling

(2014) Qiong Xing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TNFR1-activated NF-κB signal transduction: regulation by the ubiquitin/proteasome system

(2014) Ingrid E Wertz   CURRENT OPINION IN CHEMICAL BIOLOGY

Transient Electrostatic Interactions Dominate the Conformational Equilibrium Sampled by Multidomain Splicing Factor U2AF65: A Combined NMR and SAXS Study

(2014) Jie-rong Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains

(2013) Rui Hao et al.   MOLECULAR CELL

NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

(2013) A. Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains

(2013) Carlos A. Castañeda et al.   STRUCTURE

The Lysine48-Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore

(2012) Yelena Kravtsova-Ivantsiv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation

(2012) Chris MacDonald et al.   EMBO REPORTS

NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80

(2012) Naotaka Sekiyama et al.   JOURNAL OF BIOMOLECULAR NMR

Cellular functions of the DUBs

(2012) M. J. Clague et al.   JOURNAL OF CELL SCIENCE

Ubiquitin chain conformation regulates recognition and activity of interacting proteins

(2012) Yu Ye et al.   NATURE

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Noncovalent Dimerization of Ubiquitin

(2011) Zhu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational Dynamics of Wild-type Lys-48-linked Diubiquitin in Solution

(2011) Takashi Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

(2011) Cameron D. Mackereth et al.   NATURE

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

(2010) Ivan Bosanac et al.   MOLECULAR CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Theory, Practice, and Applications of Paramagnetic Relaxation Enhancement for the Characterization of Transient Low-Population States of Biological Macromolecules and Their Complexes

(2009) G. Marius Clore et al.   CHEMICAL REVIEWS

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3

(2009) Yusuke Sato et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

(2009) Azusa Yoshikawa et al.   FEBS LETTERS

The Structure and Conformation of Lys63-Linked Tetraubiquitin

(2009) Ajit B. Datta et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploring the Linkage Dependence of Polyubiquitin Conformations Using Molecular Modeling

(2009) David Fushman et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

(2009) Yogesh Kulathu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture

(2009) Stephen D. Weeks et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

Recognition Dynamics Up to Microseconds Revealed from an RDC-Derived Ubiquitin Ensemble in Solution

(2008) O. F. Lange et al.   SCIENCE