Article
Agriculture, Dairy & Animal Science
Julia Hoffelner, Walter Peinhopf-Petz, Thomas Wittek
Summary: This study assessed the association between an on-farm clinical scoring system and lung ultrasonography with the postmortem inspection of veal calf lungs. The results showed that both ultrasonography and clinical scoring are reliable methods for detecting lung diseases in veal calves.
Article
Business
Horst Treiblmaier
Summary: Cryptocurrencies can be seen as either a unique opportunity to end debt-based fiat money or a threat to the established financial order that ensures economic stability, depending on one's perspective. The debate surrounding cryptocurrencies often revolves around the question of whether they hold any intrinsic value at all. This conceptual paper suggests alternative propositions that could have substantial implications for the economic classification of cryptocurrencies.
ELECTRONIC MARKETS
(2022)
Article
Medicine, Research & Experimental
Huiru Cao, Liuming Zhu, Lin Li, Wei Wang, Xiaoping Niu
Summary: This study aimed to investigate the predictive values of serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA125 and CA724 in the diagnosis of gastrointestinal tumors. It was found that serum CEA level was correlated with tumor stage and metastasis, while CA199 was correlated with tumor stage, lymph node involvement and metastasis. CA125 and CA724 showed no correlation with tumor pathological features. Serum CEA, CA199 and CA125 levels were significantly elevated in the tumor group compared to the control group. Multiple-marker combination of CEA + CA199 + CA125 had the best diagnostic efficacy in gastric cancer, esophageal cancer, pancreatic cancer, gallbladder cancer and colorectal cancer.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mengjuan Xing, Hui Gao, Lili Yao, Li Wang, Chengfang Zhang, Liping Zhu, Donghong Cui
Summary: This study investigated the association between the intestinal microbiota and metabolic status in Chinese schizophrenia patients with MetS. The results showed significant differences in fecal microbial diversity and composition between patients with and without MetS. Furthermore, metabolic-related parameters were significantly correlated with the abundance of altered microbiota. The diagnostic model based on the composition of intestinal microbiota effectively distinguished between patients with and without MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Michael Y. Henein, Per Lindqvist
Summary: This study indicates that relative wall thickness and relative apical sparing have higher predictive value in identifying ATTR-CA, while myocardial work is more closely related to biomarkers but has relatively lower accuracy in diagnosing ATTR-CA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Anna Zogas
Summary: This study aimed to understand the experiences of military veterans and healthcare providers in identifying the personal histories of combat-related mild traumatic brain injury (mTBI) months or years after the injury. The study found that veterans and staff had different understandings of the value of neuroimaging and diagnostic certainty in clinical care. Improving patient-provider communication can be achieved through conversations about common norms of diagnosis and educating patients about the diagnostic process.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Obstetrics & Gynecology
Shuai Liu, Zhiheng Chen, Hui Wang, Li Yang, Caiqi Ma, Ling Sun
Summary: The study found that prewash and postwash total progressively motile sperm counts have poor predictive value for clinical pregnancy in intrauterine insemination (IUI). There was no apparent correlation between TPMSC and clinical pregnancy across different risk factors. Effective IUI treatment cycles can achieve good pregnancy rates with a prewash TPMSC of 10-100 million or postwash TPMSC of 3-10 million.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Gastroenterology & Hepatology
Dorte Wichmann, Silvio Nadalin, Ulrich Schweizer, Wiebke Solass, Christoph Steidle, Dietmar Stueker, Jessica Lange, Christoph R. Werner, Alfred Koenigsrainer, Markus Quante
Summary: This study aimed to evaluate the diagnostic value of endoscopy in predicting acute cellular rejection and compare it with routine allograft biopsies. The results showed that allograft endoscopy could effectively diagnose acute cellular rejection, providing important insights for improving allograft monitoring protocols.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Jing-Jing Nie, Ya-Ya Pian, Ji-Hong Hu, Guo-Qing Fan, Lv-Tao Zeng, Qiu-Geng Ouyang, Zhen-Xiang Gao, Zhen Liu, Chen-Chen Wang, Qian Liu, Jian-Ping Cai
Summary: Acute infection induced by Shigella flexneri causes increased RNA oxidative damage in various tissues (liver, spleen, and brain) and an increase of the urinary metabolite 8-oxo-Gsn. Urinary 8-oxo-Gsn may serve as a useful biomarker for evaluating the severity and prognosis of infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Marian Dejaeger, Leen Antonio, Roger Bouillon, Hannes Moors, Frederick C. W. Wu, Terence W. O'Neill, Ilpo T. Huhtaniemi, Giulia Rastrelli, Gianni Forti, Mario Maggi, Felipe F. Casanueva, Jolanta Slowikowska-Hilczer, Margus Punab, Evelien Gielen, Jos Tournoy, Dirk Vanderschueren
Summary: Vitamin D deficiency in aging men is associated with a 2-fold increased risk of mortality. Concentrations of free 25(OH)D and 1,25(OH)(2)D provide no additional information on mortality risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medical Laboratory Technology
Changfei Mao, Min Wang, Li Li, Jin-Hai Tang
Summary: By analyzing the serum metabolomics, we found that L-arginine and arachidonic acid were elevated in trastuzumab-responsive and trastuzumab-resistant HER2-positive breast cancer patients. We developed an equation for assessing the risk scores, which can improve the early diagnosis of HER2-positive breast cancer and the therapeutic effects of trastuzumab therapy.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Endocrinology & Metabolism
Mark M. Smits, Kristina S. Fluitman, Hilde Herrema, Mark Davids, Mark H. H. Kramer, Albert K. Groen, Clara Belzer, Willem M. de Vos, Djuna L. Cahen, Max Nieuwdorp, Daniel H. van Raalte
Summary: The study aimed to investigate the effects of GLP-1 receptor agonists and DPP-4 inhibitors on the intestinal microbiota in adults with type 2 diabetes. Results showed that these agents did not affect the diversity of the intestinal microbiota, nor were changes in microbial composition related to clinical parameters.
DIABETES & METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Jie Wu, Zhiheng Huang, Min Ji, Zhinong Jiang, Yuhuan Wang, Zifei Tang, Ying Huang
Summary: Video capsule endoscopy is a valuable diagnostic tool for pediatric intestinal lymphangiectasia, providing an important and less invasive method for confirming or establishing a diagnosis. Common symptoms include hypoproteinemia, diarrhea, edema, and abdominal pain, with patients often treated with medium-chain triglyceride diets, albumin infusions, and sirolimus therapy.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2021)
Letter
Psychology, Clinical
Victor Peralta, Manuel J. Cuesta
Summary: Using a phenomenological approach, this study found that first-rank symptoms (FRS) do not have diagnostic value for schizophrenia and have lower predictive validity compared to other delusions and hallucinations. The confusion about the diagnostic and clinical validity of FRS is mainly due to Schneider's confusing concept of the disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Yoshitatsu Sei, Joanne Forbes, Ben Da, Ehsan Chitsaz, Jianying Feng, Xilin Zhao, Marybeth S. Hughes, Stephen A. Wank
Summary: Early detection of cryptal EEC clusters can provide insights into the development of SI-NETs and allow successful pre-symptomatic screening for at-risk family members. SI-NETs develop from deep crypt EC cells to become ACECs, micro-tumors, and ultimately gross tumors.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jill Derix, Richard Ducatelle, Bart Pardon, Evi Croes, Niels Groot Nibbelink, Linda Van Deurzen-Duineveld, Filip Van Immerseel, Evy Goossens
Summary: Necro-hemorrhagic enteritis in calves, caused by Clos-tridium perfringens type A, is a fatal disease affecting calves in intensive rearing systems. Lack of development of active immunity against alpha toxin is the main trigger. This study investigates the effect of milk replacer components on alpha toxin production and the effect of lactose on antibody production.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Stan Jourquin, Thomas Lowie, Florian Debruyne, Laurens Chantillon, Nick Vereecke, Filip Boyen, Randy Boone, Jade Bokma, Bart Pardon
Summary: This prospective cohort study aims to investigate the dynamics of lung consolidation in male dairy calves and its association with antimicrobial therapy, respiratory diagnostics, average daily gain (ADG), and cold carcass weight (CCW). The study found a high incidence of lung consolidation upon arrival and a significant association with chronic pneumonia and reduced performance.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Veterinary Sciences
Mathilde L. L. Pas, Jade Bokma, Thomas Lowie, Filip Boyen, Bart Pardon
Summary: This study aimed to identify factors associated with mortality in critically ill calves and describe bacteria obtained from blood cultures of calves with sepsis and their antimicrobial resistance. The results showed that sepsis, abnormal behavior, and hypothermia were significantly associated with higher mortality risk. Escherichia coli was the most frequently isolated bacteria, with a high percentage of multidrug resistance. The study highlights the importance of appropriate antimicrobial use in treating critically ill calves.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Pathology
Bert De Jonge, Bart Pardon, Evy Goossens, Filip Van Immerseel, Nick Vereecke, Mathilde L. Pas, Jozefien Callens, Nermin Caliskan, Stefan Roels, Koen Chiers
Summary: Hemorrhagic bowel syndrome (HBS) is a sporadic and fatal disease in lactating dairy cattle, characterized by segmental hemorrhage and clot formation in the small intestine. The pathogenesis and cause of HBS are currently unknown, despite the association with Clostridium perfringens and Aspergillus fumigatus.
VETERINARY PATHOLOGY
(2023)
Article
Microbiology
Tessa Dehau, Marc Cherlet, Siska Croubels, Filip van Immerseel, Evy Goossens
Summary: Dietary additives, such as berberine, are used to reduce intestinal inflammation in the broiler industry. This study investigated the effects of berberine on gut microbiota and gut health in chickens. Berberine was found to improve gut morphology and decrease inflammation, and it also influenced the diversity and composition of the gut microbiota. The study suggests that berberine supplementation at an optimal dose can be beneficial for chicken gut health.
Article
Veterinary Sciences
Katrien Rysman, Venessa Eeckhaut, Richard Ducatelle, Evy Goossens, Filip Van Immerseel
Summary: Maintaining optimal gut health is crucial for the performance of broiler flocks. This study investigated the relationship between intestinal villus structure and inflammation with Ross 308 broiler performance in commercial farms. A significant association was found between gut villus structure and bird performance, emphasizing the importance of gut health in commercial conditions.
Review
Biochemistry & Molecular Biology
Junhua Xie, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: Bacterial extracellular vesicles (bEVs) have been shown to play a crucial role in the pathogenesis of various diseases. This article thoroughly discusses the contribution of bEVs in disease pathogenesis, their potential as diagnostic biomarkers, and their application as therapeutic targets.
TRENDS IN MICROBIOLOGY
(2023)
Article
Microbiology
Martina Husta, Svitlana Tretiak, Richard Ducatelle, Filip Van Immerseel, Evy Goossens
Summary: This study evaluated the behavior of C. perfringens in different intestinal compartments of broiler chickens during a NE trial. The results showed that necrotic enteritis-associated lesions were mainly found in the jejunum and were more severe compared to the duodenum and ileum. There was a positive correlation between the total number of vegetative C. perfringens cells in the intestinal compartments and disease severity. C. perfringens was mainly present as spores in the caecum and distal colon.
VETERINARY MICROBIOLOGY
(2023)
Article
Infectious Diseases
Francisco Cortez Nunes, Emily Taillieu, Teresa Letra Mateus, Silvia Teixeira, Freddy Haesebrouck, Irina Amorim
Summary: This study aimed to assess the presence of antibiotic resistance genes previously reported in Helicobacter pylori in gastric samples from 36 pigs where DNA of H. pylori-like organisms had been detected. Based on PCR and sequencing analysis, two samples were positive for the 16S rRNA mutation gene conferring tetracycline resistance, and one sample was positive for the frxA gene conferring metronidazole resistance. These findings indicate the potential occurrence of acquired antimicrobial resistance in H. pylori-like organisms associated with pigs.
Article
Veterinary Sciences
Justine Clinquart, Katharina van Leenen, Jade Bokma, Bart Pardon
Summary: This study distinguishes different cytological profiles in nonbronchoscopic bronchoalveolar lavage (nBAL) from grouped housed calves and characterizes these profiles on individual and herd levels. The study provides a first step in the development of cytological guidelines for the assessment of airway health and inflammation in calves through nBAL fluid cytology.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Marielen de Souza, Venessa Eeckhaut, Evy Goossens, Richard Ducatelle, Filip Van Nieuwerburgh, Karl Poulsen, Ana Angelita Sampaio Baptista, Ana Paula Frederico Rodrigues Loureiro Bracarense, Filip Van Immerseel
Summary: Galactomannans in broiler feed can negatively impact zootechnical performance and gut microbiota composition. Mannanase supplementation can restore the gut microbiota and improve performance to normal levels.
Article
Agriculture, Dairy & Animal Science
Richard Ducatelle, Evy Goossens, Venessa Eeckhaut, Filip Van Immerseel
Summary: Intestinal health is crucial for digestion and nutrient absorption, which directly impacts performance. High performing poultry lines often face intestinal health issues due to high feed intake, putting pressure on the digestive system. Excess undigested nutrients can lead to dysbiosis and inflammation, causing gut leakage. This paper reviews key factors and nutritional tools to support intestinal health.
Article
Veterinary Sciences
Yue Huang, Venessa Eeckhaut, Evy Goossens, Geertrui Rasschaert, Johan Van Erum, Geert Roovers, Richard Ducatelle, Gunther Antonissen, Filip Van Immerseel
Summary: Bacterial chondronecrosis with osteomyelitis (BCO) is a common cause of broiler lameness. Enterococcus cecorum is frequently isolated from BCO cases and the bacteria are believed to originate from the intestinal tract. BCO strains and intestinal strains of E. cecorum show genetic differences, with the former exhibiting increased virulence.
VETERINARY RESEARCH
(2023)
Review
Veterinary Sciences
Emily Taillieu, Koen Chiers, Irina Amorim, Fatima Gaertner, Dominiek Maes, Christophe Van Steenkiste, Freddy Haesebrouck
Summary: This article discusses the importance of Helicobacter species in dogs, cats, and pigs and their potential to infect humans. The article highlights the association of Helicobacter suis with gastritis and decreased weight gain in pigs, as well as its potential to cause disease in humans. It also mentions that multiple Helicobacter species can colonize the stomachs of dogs and cats, but their pathogenic significance is likely low. The article concludes that besides H. pylori, gastric Helicobacter species associated with these animals are also clinically relevant in humans.
VETERINARY RESEARCH
(2022)