Article
Medicine, General & Internal
Saskia C. van der Boor, Manon Alkema, Geert-Jan van Gemert, Karina Teelen, Marga van de Vegte-bolmer, Jona Walk, Reinout van Crevel, Quirijn de Mast, Christian F. Ockenhouse, Robert W. Sauerwein, Matthew B. B. McCall
Summary: The use of NF135 strain of Plasmodium falciparum in whole sporozoite immunization regime showed low tolerance and frequent need for rescue treatment, compromising the effectiveness and protective efficacy of the immunization.
Article
Immunology
Frank Wunderlich, Denis Delic, Daniela Gerovska, Marcos J. Arauzo-Bravo
Summary: This study found that protective vaccination can accelerate extramedullary hepatic megakaryo-/thrombopoiesis in response to malaria. Vaccinated mice showed higher expression levels of megakaryo-/thrombocytic genes in the liver at early stages of infection compared to non-vaccinated mice.
Review
Microbiology
Carola Schafer, Gigliola Zanghi, Ashley M. Vaughan, Stefan H. I. Kappe
Summary: Plasmodium vivax, the most widespread human malaria parasite, can form latent liver stages known as hypnozoites which can activate weeks, months, or even years after the primary infection, causing relapses of blood stage infection. Eliminating hypnozoites is a major obstacle for malaria treatment and eradication as they are undetectable and unaffected by most antimalarial drugs.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021
(2021)
Article
Microbiology
Nicole M. Davis, Michelle M. Lissner, Crystal L. Richards, Victoria Chevee, Avni S. Gupta, Frank C. Gherardini, David S. Schneider
Summary: The study focuses on how host metabolism changes in relation to disease severity in murine malaria, identifying plasma metabolic biomarkers for different malarial pathologies. The research also reveals connections between plasma metabolomes of human malaria patients and metabolic changes in malarial mice. Specifically, liver damage in infected mice releases hepatic arginase-1 into circulation, leading to plasma arginine depletion, which may have implications for malaria therapeutics.
Article
Immunology
Maelle Le Goff, Eric Kendjo, Marc Thellier, Renaud Piarroux, Pierre Yves Boelle, Stephane Jaureguiberry
Summary: This study analyzed the impact of chemoprophylaxis on the outcomes of Plasmodium vivax and Plasmodium ovale infections in civilian travelers. It found that travelers using blood-stage drugs were at a higher risk of delayed-onset illness. This calls for new chemoprophylaxis acting on liver stages.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Gozde Deveci, Mohd Kamil, Ahmed S. I. Aly
Summary: Genetically-growth-attenuated blood-stage parasites were developed and shown to induce sterile protection against homologous blood-stage infection. Immunization with frozen stocks of mixed berghei and P. yoeliint(-) parasites in subcutaneous doses conferred sterile protection against intravenous infectious blood-stage challenge. This finding suggests the potential development of a single subcutaneous sub-patent dose of genetically-growth-attenuated parasites as a protective measure against multiple Plasmodium spp. infections.
Article
Biology
Tsukushi Kamiya, Nicole M. Davis, Megan A. Greischar, David Schneider, Nicole Mideo
Summary: Our study revealed that high host mortality during acute malaria infection could be attributed to weak parasite clearance or inadvertent removal of uninfected cells in excess. Molecular immunology assays indicated that these two distinct mechanisms of poor survival might be due to low expression of certain inflammatory cytokines.
Editorial Material
Immunology
Jonathan S. Schultz, Kimberly E. Mace, Kathrine R. Tan
Summary: The increase in international travel during the COVID-19 pandemic recovery period is expected to lead to an increase in imported malaria cases in the US. Prevention, timely diagnosis, and appropriate treatment are crucial in minimizing imported malaria morbidity and mortality. Intravenous artesunate (IVAS) is now available for severe malaria treatment in the US. Hospitals and pharmacists should have a malaria treatment plan that includes stocking artemether-lumefantrine for uncomplicated malaria and ensuring access to IVAS for severe cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Said A. Jongo, Vicente Urbano, L. W. Preston Church, Ally Olotu, Stephen R. Manock, Tobias Schindler, Ali Mtoro, K. C. Natasha, Ali Hamad, Elizabeth Nyakarungu, Maximillian Mpina, Anna Deal, Jose Raso Bijeri, Martin Eka Ondo Mangue, Beltran Ekua Ntutumu Pasialo, Genaro Nsue Nguema, Salomon Nguema Owono, Matilde Riloha Rivas, Mwajuma Chemba, Kamaka R. Kassim, Eric R. James, Thomas C. Stabler, Yonas Abebe, Elizabeth Saverino, Julian Sax, Salome Hosch, Anneth-Mwasi Tumbo, Linda Gondwe, J. Luis Segura, Carlos Cortes Falla, Wonder Philip Phiri, Dianna E. B. Hergott, Guillermo A. Garcia, Christopher Schwabe, Carl D. Maas, Tooba Murshedkar, Peter F. Billingsley, Marcel Tanner, Mitoha Ondo'o Ayekaba, B. Kim Lee Sim, Claudia Daubenberger, Thomas L. Richie, Salim Abdulla, Stephen L. Hoffman
Summary: In African vaccinees, Plasmodium falciparum sporozoite-CVac recipients demonstrated a higher vaccine efficacy, likely due to later stage parasite maturation leading to induction of cellular immunity against a broader array of antigens.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Microbiology
Minami Baba, Mamoru Nozaki, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino
Summary: The protein RON4 plays a crucial role in the infection of liver by Plasmodium parasites. It is involved in the crossing of sinusoidal cells and invasion of hepatocytes, contributing to the sporozoite's ability to adhere and move. This finding provides important insights into the invasion mechanisms of Apicomplexa parasites.
Article
Chemistry, Medicinal
Jessica Poole, Lauren E. Hartley-Tassell, Christopher J. Day, Danielle Stanisic, Penny L. Groves, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman, Joe Tiralongo, Nicolai Bovin, Denise L. Doolan, Michael P. Jennings
Summary: The transmission of Plasmodium spp. sporozoites to the mammalian host is crucial for the development of malaria, yet the exact route of transmission and the host glycan structures involved are not fully understood. By analyzing the glycan structures recognized and bound by sporozoites from P. falciparum and P. yoelii, this study identified key host glycan structures for human and rodent Plasmodium spp. sporozoites. Understanding how these sporozoites interact with specific glycan structures could offer insight into the infectious disease and aid in the development of effective therapeutics.
ACS INFECTIOUS DISEASES
(2021)
Article
Microbiology
Calvin Hon, Johannes Friesen, Alyssa Ingmundson, Diana Scheppan, Julius C. R. Hafalla, Katja Mueller, Kai Matuschewski
Summary: This study demonstrates the importance of a conserved and immunogenic protein S20 expressed by malaria parasites for protective immunity. Although S20 is not necessary for establishment of infection, it may play potential roles in diverting cellular immune responses.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
James G. Kublin, Sean C. Murphy, Janine Maenza, Annette M. Seilie, Jay Prakash Jain, David Berger, Danielle Spera, Rong Zhao, Rachel L. Soon, Julie L. Czartoski, Meredith A. Potochnic, Elizabeth Duke, Ming Chang, Ashley Vaughan, Stefan H. Kappe, F. Joel Leong, Peter Pertel, William T. Prince
Summary: KAF156, a novel antimalarial drug with high protective efficacy, was found to be safe and well tolerated in a controlled human malaria infection model. Different doses of KAF156 showed varying levels of protection against malaria infection, with higher doses providing greater protection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Charlie Jennison, Janna M. Armstrong, Dorender A. Dankwa, Nina Hertoghs, Sudhir Kumar, Biley A. Abatiyow, Myo Naung, Nana K. Minkah, Kristian E. Swearingen, Robert Moritz, Alyssa E. Barry, Stefan H. I. Kappe, Ashley M. Vaughan
Summary: Plasmodium parasites, the eukaryotic pathogens that cause malaria, have three distinct invasive forms adapted to different host environments. Micronemes, a type of secretory organelle, play crucial roles in egress, motility, adhesion, and invasion. This study demonstrates that GPI-anchored micronemal antigen (GAMA) is involved in sporozoite motility, egress, and invasion, suggesting its role as a regulator of microneme function. The findings also show conservation of GAMA's function across Plasmodium species.
MOLECULAR MICROBIOLOGY
(2023)
Article
Microbiology
Carson Bowers, Lisa Hancox, Kristen Peissig, Justine C. C. Shiau, Amelie Vantaux, Benoit Witkowski, Sivchheng Phal, Steven P. P. Maher, John T. T. Harty, Dennis E. E. Kyle, Samarchith P. P. Kurup
Summary: This study presents a method for cryopreservation of malaria sporozoites, which successfully preserves their structural integrity, viability, and infectiousness, as well as transgenic properties. The research offers a reliable protocol for the long-term storage and recovery of human and murine malaria sporozoites and lays the groundwork for the widespread use of live sporozoites for research and clinical applications.
Article
Infectious Diseases
Deirdre A. Cunningham, Jing-wen Lin, Thibaut Brugat, William Jarra, Irene Tumwine, Garikai Kushinga, Jai Ramesar, Blandine Franke-Fayard, Jean Langhorne
Article
Microbiology
Thibaut Brugat, Adam James Reid, Jing-wen Lin, Deirdre Cunningham, Irene Tumwine, Garikai Kushinga, Sarah McLaughlin, Philip Spence, Ulrike Boehme, Mandy Sanders, Solomon Conteh, Ellen Bushell, Tom Metcalf, Oliver Billker, Patrick E. Duffy, Chris Newbold, Matthew Berriman, Jean Langhorne
NATURE MICROBIOLOGY
(2017)
Article
Medicine, General & Internal
Damian Perez-Mazliah, Minh Phuong Nguyen, Caroline Hosking, Sarah McLaughlin, Matthew D. Lewis, Irene Tumwine, Prisca Levy, Jean Langhorne
Article
Multidisciplinary Sciences
Jing-wen Lin, Jan Sodenkamp, Deirdre Cunningham, Katrien Deroost, Tshibuayi Christine Tshitenge, Sarah McLaughlin, Tracey J. Lamb, Bradley Spencer-Dene, Caroline Hosking, Jai Ramesar, Chris J. Janse, Christine Graham, Anne O'Garra, Jean Langhorne
SCIENTIFIC REPORTS
(2017)
Article
Biology
Damian Perez-Mazliah, Peter J. Gardner, Edina Schweighoffer, Sarah McLaughlin, Caroline Hosking, Irene Tumwine, Randall S. Davis, Alexandre J. Potocnik, Victor L. J. Tybulewicz, Jean Langhorne
Review
Immunology
Damian Perez-Mazliah, Francis M. Ndungu, Racheal Aye, Jean Langhorne
IMMUNOLOGICAL REVIEWS
(2020)
Article
Immunology
Natasha L. Smith, Wiebke Nahrendorf, Catherine Sutherland, Jason P. Mooney, Joanne Thompson, Philip J. Spence, Graeme J. M. Cowan
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biology
Kathryn Milne, Alasdair Ivens, Adam J. Reid, Magda E. Lotkowska, Aine O'Toole, Geetha Sankaranarayanan, Diana Munoz Sandoval, Wiebke Nahrendorf, Clement Regnault, Nick J. Edwards, Sarah E. Silk, Ruth O. Payne, Angela M. Minassian, Navin Venkatraman, Mandy J. Sanders, Adrian V. S. Hill, Michael Barrett, Matthew Berriman, Simon J. Draper, J. Alexandra Rowe, Philip J. Spence
Summary: This study found that falciparum malaria displays clinical heterogeneity, with some volunteers triggering inflammatory responses and experiencing hallmark symptoms of malaria. The research also showed that there was no evidence of rapid expansion of parasite variants associated with severe disease in naive hosts, suggesting that the dominant parasite variants in severe malaria do not have an intrinsic growth advantage.
Article
Biology
Wiebke Nahrendorf, Alasdair Ivens, Philip J. Spence
Summary: Research shows that a single malaria episode can induce host adaptations that minimize inflammation, prevent tissue damage, and avert severe disease. This acquired immunity to malaria prioritizes host fitness over pathogen clearance, operating independently of pathogen load.
Article
Immunology
Jo Salkeld, Yrene Themistocleous, Jordan R. Barrett, Celia H. Mitton, Thomas A. Rawlinson, Ruth O. Payne, Mimi M. Hou, Baktash Khozoee, Nick J. Edwards, Carolyn M. Nielsen, Diana Munoz Sandoval, Florian A. Bach, Wiebke Nahrendorf, Raquel Lopez Ramon, Megan Baker, Fernando Ramos-Lopez, Pedro M. Folegatti, Doris Quinkert, Katherine J. Ellis, Ian D. Poulton, Alison M. Lawrie, Jee-Sun Cho, Fay L. Nugent, Philip J. Spence, Sarah E. Silk, Simon J. Draper, Angela M. Minassian
Summary: Repeated controlled human malaria infection (CHMI) with the same parasite did not show clear evidence of anti-parasite immunity in most participants, although some individuals exhibited variation in parasite growth dynamics. However, repeat homologous blood-stage CHMI proved to be safe and offers a model for studying naturally acquired immunity to blood-stage infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Deirdre A. A. Cunningham, Adam J. J. Reid, Caroline Hosking, Katrien Deroost, Irene Tumwine-Downey, Mandy Sanders, Jean Langhorne
Summary: In this study, the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi were analyzed in male and female gametocytes isolated from infected mice blood. The results showed that infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns resemble those observed in the closely related P. berghei, but this study highlights the differentiation of gametocyte-associated pir genes from those involved in chronic blood-stage infection and identifies a male-associated pir gene of interest for future studies.
BMC RESEARCH NOTES
(2023)
Correction
Biology
Carlos Talavera-Lopez, Barbara Capuccini, Richard Mitter, Jing-wen Lin, Jean Langhorne
BMC RESEARCH NOTES
(2019)
