Journal
VETERINARY PATHOLOGY
Volume 51, Issue 2, Pages 363-371Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985813511128
Keywords
prion-like transmission; cheetah; amyloid-enhancing factor; serum amyloid A; mouse; AA amyloidosis; bird; cattle
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [23390093, 22020015, 23659150]
- Intractable Disease Division of the Ministry of Health, Labor, and Welfare
- Grants-in-Aid for Scientific Research [23390093, 23659150, 22020015] Funding Source: KAKEN
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Amyloidoses are a group of protein-misfolding disorders that are characterized by the deposition of amyloid fibrils in organs and/or tissues. In reactive amyloid A (AA) amyloidosis, serum AA (SAA) protein forms deposits in mice, domestic and wild animals, and humans that experience chronic inflammation. AA amyloid fibrils are abnormal beta-sheet-rich forms of the serum precursor SAA, with conformational changes that promote fibril formation. Extracellular deposition of amyloid fibrils causes disease in affected animals. Recent findings suggest that AA amyloidosis could be transmissible. Similar to the pathogenesis of transmissible prion diseases, amyloid fibrils induce a seeding-nucleation process that may lead to development of AA amyloidosis. We review studies of possible transmission in bovine, avian, mouse, and cheetah AA amyloidosis.
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