Journal
VETERINARY PATHOLOGY
Volume 49, Issue 5, Pages 755-759Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985811415703
Keywords
cyanobacterium; dog; hepatic necrosis; kidney; liquid chromatography-mass spectrometry; liver; nodularin; renal tubular necrosis
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A 3-year-old Cairn Terrier dog that had been in contact with sea water containing cyanobacteria (blue-green algae) was euthanized because of acute hepatic failure and anuria after a 5-day illness. Histologic findings included lytic and hemorrhagic centrilobular hepatocellular necrosis and renal tubular necrosis. The cyanotoxin nodularin was detected in liver and kidney by high-performance liquid chromatography-mass spectrometry. Nodularin is a potent hepatotoxin produced by the algal species Nodularia spumigena. The intensity of algal blooms has increased during the past decades in the Baltic Sea region, thus increasing the risk for intoxications in domestic and wild animals. The authors describe the pathologic findings of cyanobacterial toxicosis in a dog with direct identification of the toxin from organ samples.
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