Article
Cell Biology
Xudong Pu, Xin Li, Lili Cao, Kaiming Yue, Panpan Zhao, Xiaocen Wang, Jianhua Li, Xichen Zhang, Nan Zhang, Zhiteng Zhao, Min Liang, Pengtao Gong
Summary: The study showed that stimulation of mouse macrophages by G. duodenalis enhanced the inflammatory response, activated TLR9, p38, and ERK signaling pathways, while silencing TLR9 attenuated the host's inflammatory response and AKT pathway inhibition exacerbated this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Parasitology
Panpan Zhao, Lili Cao, Xiaocen Wang, Jianhua Li, Jingquan Dong, Nan Zhang, Xin Li, Shan Li, Min Sun, Xichen Zhang, Min Liang, Xudong Pu, Pengtao Gong
Summary: The study demonstrates that GEVs can enhance G. intestinalis-induced inflammatory responses in mouse macrophages by activating the p38, ERK, and NF-kappa B signaling pathways. Understanding the role of GEVs in regulating host cell immune responses may offer insights into the mechanisms underlying G. intestinalis-host interactions.
PARASITES & VECTORS
(2021)
Article
Veterinary Sciences
Zhao-Jun Heng, Jian-Fa Yang, Xin-Yan Xie, Cui-Rong Xu, Jun-Rong Chen, Jun Ma, Jun-Jun He, Hua-Ming Mao
Summary: This study investigated the occurrence and genetic diversity of Giardia duodenalis in Holstein cattle in Yunnan Province, China. The results showed a high infection rate in preweaned calves, with assemblage E being the predominant group. Mixed infection of assemblages A and E was also detected in three samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Ho Yin Pekkle Lam, Tina Tu-Wen Chen, Yu-Chuan Tseng, Kai-Chih Chang, Ting-Hua Yang, Shih-yi Peng
Summary: The first epidemiological investigation of G. duodenalis infection in animals in Hualien, Taiwan was conducted, revealing infection rates of 19.87% for cattle and 4.26% for pigs. Assemblage A was detected in pigs, indicating potential zoonotic transmission.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Zhikun Zhang, Haiwei Dou, Peng Tu, Dawei Shi, Ran Wei, Ruijie Wan, Chunmei Jia, Lihua Ning, Dongmei Wang, Jing Li, Yan Dong, Deli Xin, Baoping Xu
Summary: This study analyzed the immune response patterns in children with Mycoplasma pneumoniae pneumonia (MPP). The results showed different immune response patterns in general MPP (GMPP) and severe MPP (SMPP), with certain cytokines potentially serving as indicators for SMPP. Early intervention in immune response regulation may help reduce the severity of SMPP.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Veterinary Sciences
Ali Taghipour, Mitra Sharbatkhori, Farideh Tohidi, Mohammad R. Ghanbari, Panagiotis Karanis, Meysam Olfatifar, Hamidreza Majidiani, Sasan Khazaei, Saeed Bahadory, Ehsan Javanmard
Summary: This study reports on the global distribution of G. duodenalis in cattle and evaluates the prevalence, risk factors, and genetic characterization of its infection. The results show that G. duodenalis infection is widespread among cattle and is associated with diarrhea and pre-weaned calves.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Immunology
Sarvin Sanaie, Elham Golipour, Ali Shamekh, Mohammad Reza Sadaie, Ata Mahmoodpoor, Mehdi Yousefi
Summary: The potential for human reinfection with SARS-CoV-2 remains uncertain despite the presence of antibodies and immune cells, as the virus can mutate and affect its spread. Both innate and adaptive immune responses in individuals play a crucial role in the dynamics of virus infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Chyna C. Gray, Bethany Biron-Girard, Michelle E. Wakeley, Chun-Shiang Chung, Yaping Chen, Yael Quiles-Ramirez, Jessica D. Tolbert, Alfred Ayala
Summary: The article investigates the role of VISTA in sepsis and finds that VISTA plays a protective role in sepsis by regulating the quantity of T-reg, reducing the incidence and mortality of sepsis. VISTA deficiency leads to a decrease in T-reg, increasing the severity of sepsis and mortality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andrea Aran, Gonzalo Lazaro, Vicente Marco, Elisa Molina, Ferran Abanco, Vicente Peg, Maria Gion, Laia Garrigos, Jose Perez-Garcia, Javier Cortes, Merce Marti
Summary: Tumor-infiltrating lymphocytes (TILs) have predictive and prognostic value in breast cancer. TCR differences between CD4+ and CD8+ TILs were observed, and a more restricted TCR repertoire with higher similarity was found in CD4+ TILs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Petra C. Fay, Najith Wijesiriwardana, Henry Munyanduki, Beatriz Sanz-Bernardo, Isabel Lewis, Ismar R. Haga, Katy Moffat, Arnoud H. M. van Vliet, Jayne Hope, Simon P. Graham, Philippa M. Beard
Summary: This study provides an in-depth analysis of the immune responses of calves experimentally inoculated with LSDV and highlights the differences in immune response between clinical and nonclinical cattle. It suggests that arthropod transmission leads to more widespread clinical disease and that early IgM production is a correlate of protection in LSD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rocio Rubio, Ruth Aguilar, Mariona Bustamante, Erica Munoz, Miquel Vazquez-Santiago, Rebeca Santano, Marta Vidal, Natalia Rodrigo Melero, Daniel Parras, Pau Serra, Pere Santamaria, Carlo Carolis, Luis Izquierdo, Maria Dolores Gomez-Roig, Carlota Dobano, Gemma Moncunill, Edurne Mazarico
Summary: SARS-CoV-2 infection during pregnancy induces a robust antibody and cytokine response at delivery and causes a significant reduction of the SARS-CoV-2-specific IgGs transplacental transfer, with a stronger negative effect when the infection is closer to delivery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hella Pasmans, Magdalena A. Berkowska, Annieck M. Diks, Bas de Mooij, Rick J. Groenland, Lia de Rond, M. Alina Nicolaie, Sjoerd H. van der Burg, Jacques J. M. van Dongen, Fiona R. M. van der Klis, Anne-Marie Buisman
Summary: A study comparing immune responses in women vaccinated with bivalent and nonavalent HPV vaccines found consistent expansion of plasma cells and monocytes, but varied responses in other immune cells. Antibody levels and memory B and T-cell responses also differed between the two vaccine groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dube, Julia Niessl, Amy E. Baxter, Olivier Tastet, Nathalie Brassard, Gloria Ortega-Delgado, Roxanne Charlebois, Gordon J. Freeman, Cecile Tremblay, Jean-Pierre Routy, Daniel E. Kaufmann
Summary: This study examined the expression and function of immune checkpoints in CD4+ T cells of HIV-infected individuals and found that the expression of immune checkpoints is associated with infection status and effector profile. In addition, different subsets of CD4+ T cells show varying sensitivity to PD-1-mediated inhibition, suggesting heterogeneity in the restoration of cell function through immune checkpoint blockade.
Article
Immunology
Emelie Marklund, Susannah Leach, Kristina Nystrom, Anna Lundgren, Jan-Ake Liljeqvist, Staffan Nilsson, Aylin Yilmaz, Lars-Magnus Andersson, Mats Bemark, Magnus Gisslen
Summary: The study found that healthcare workers caring for COVID-19 patients in Sweden have a higher rate of SARS-CoV-2 infection compared to blood donors. There is significant variation between different IgG assays, suggesting that multiple serological targets should be used to confirm past infection. CD4(+) T-cell reactivity is not a suitable measure of past infection and does not reliably indicate protection from infection in naive individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Ophthalmology
Jordan L. Mitchell, Laura Ganis, Benjamin T. Blacklock, Harry Petrushkin, Jayne C. Hope, Danielle A. Gunn-Moore
Summary: Tuberculosis is an ancient infectious disease that causes millions of deaths each year in humans, as well as significant morbidity and mortality in animals. Ocular tuberculosis is a recognized condition in humans, but its occurrence in animals, such as cattle and domestic cats, requires further investigation in order to improve treatment outcomes.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Camille Wagner, Anneleen Remmerie, Anna Bujko, Liesbet Martens, Tinne Thone, Robin Browaeys, Federico F. De Ponti, Bavo Vanneste, Christian Zwicker, Freya R. Svedberg, Tineke Vanhalewyn, Amanda Goncalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J. F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
Summary: This study presents a spatial proteogenomic atlas of the liver, combining multiple omics datasets, and reveals the cellular niches and transcriptomic identities of Kupffer cells and lipid-associated macrophages. It also demonstrates the inducibility of lipid-associated macrophages by local lipid exposure and the crucial role of ALK1-BMP9/10 axis in Kupffer cell development.
Article
Agriculture, Dairy & Animal Science
Kwangwook Kim, Yijie He, Cynthia Jinno, Lauren Kovanda, Xunde Li, David Bravo, Eric Cox, Yanhong Liu
Summary: The supplementation of Coligo in weaned pigs infected with ETEC showed similar effects to antibiotics in promoting growth, reducing diarrhea severity, and improving gut health.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yue Yin, Jinglin Ma, Cliff Van Waesberghe, Bert Devriendt, Herman W. W. Favoreel
Summary: This study investigates whether PRV triggers the expression of type I and III interferons and whether these interferons have antiviral activity against PRV in different porcine epithelial cells. The results show that the antiviral response and activity of type I and III interferons depend on the type of epithelial cells used, and it is the first time that type III interferon displays antiviral activity against PRV in respiratory and intestinal epithelial cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin, as an alternative for antimicrobials, shows potential in preventing ETEC infections in pigs by reducing fluid secretion and colonization ability of ETEC.
Article
Veterinary Sciences
Emma Heyman, Marguerite Meeremans, Bert Devriendt, Maria Olenic, Koen Chiers, Catharina De Schauwer
Summary: This study presents a method to quantify the tri-lineage differentiation potential of mesenchymal stem cells (MSCs) using digital image analysis. By staining and calculating the area percentages, the differentiation potential of MSCs from different donors can be accurately evaluated. This straightforward method can be used for further optimization of regenerative medicine therapies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Parasitology
Johannes Charlier, Diana J. Williams, Nadine Ravinet, Edwin Claerebout
Summary: Helminth infections of cattle have significant impacts on livestock production and farm economic efficiency. Subclinical infections, which have hidden impacts on animals, require refined diagnostics to detect and inform farmers about the likely impact of anthelmintic treatment. Recent advances in diagnosing major cattle helminth infections and searching for subclinical infection thresholds can help farmers tailor helminth treatments to specific epidemiological circumstances, thereby limiting anthelmintic resistance and boosting agricultural efficiency and food security.
TRENDS IN PARASITOLOGY
(2023)
Article
Immunology
Jordan L. Mitchell, Chris Wilson, Janet E. Alexander, Shelley G. Rhodes, Danielle A. Gunn-Moore, Jayne C. Hope
Summary: In order to facilitate the diagnosis of feline tuberculosis (TB), an optimized enzyme-linked immunosorbent assay (ELISA) was developed and tested. The ELISA showed a sensitivity of 64.3% and specificity of 100% when used on cats with culture-confirmed TB. When tested on cats with strongly suspected mycobacteriosis, the sensitivity was 32.9%. These results suggest that antibody-based diagnostics can be a useful adjunctive test for cases of TB missed by the IGRA.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2023)
Article
Immunology
Lisa Beuckelaere, Maarten Haspeslagh, Evelien Biebaut, Filip Boyen, Freddy Haesebrouck, Roman Krejci, Evelyne Meyer, David Gleerup, Ward De Spiegelaere, Bert Devriendt, Dominiek Maes
Summary: This study investigated the effects of infection with, and vaccination against Mycoplasma hyopneumoniae on the innate and adaptive immune responses in pigs. Results showed that the two commercial bacterins induced different immune responses, the adjuvant alone reduced anti-inflammatory innate immune responses, and both vaccines had different efficacy in reducing lung lesions and M. hyopneumoniae DNA load.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara Tomaiuolo, Wiebke Jansen, Susana Soares Martins, Bert Devriendt, Eric Cox, Marcella Mori
Summary: Coxevac (R) is an approved veterinary vaccine for Q fever in cattle and goats. The addition of QuilA (R) adjuvant enhances the immune response and increases the vaccine-induced bacterial clearance, potentially improving the efficacy of Coxevac (R) against C. burnetii infection.
Review
Veterinary Sciences
Marieke Brys, Edwin Claerebout, Koen Chiers
Summary: Chronic progressive lymphedema (CPL) in draft horses is a serious condition with severe clinical signs, including progressive swelling of the limbs, dermal fibrosis, and the development of skinfolds and nodules. Despite the severity of the disease, uncertainties regarding its cause and progression remain. This review discusses possible hypotheses for CPL's pathogenesis, summarizes advances in diagnosis and management, and presents a new scoring system for assessing clinical severity.
VETERINARY SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Johannes Charlier, Tong Wang, Sien H. Verschave, Johan Hoeglund, Edwin Claerebout
Summary: Gastrointestinal nematode infections pose a significant threat to the health and well-being of calves in pasture-based rearing systems. The serum pepsinogen assay, although an established tool, is not widely implemented due to its high cost and lack of standardization. This study evaluates the O. ostertagi-Ab ELISA as a cost-effective and robust alternative diagnostic method for first-season grazing calves and suggests that it can replace the serum pepsinogen assay for monitoring purposes at the end of the grazing season.
Article
Veterinary Sciences
Evelien Biebaut, Lisa Beuckelaere, Filip Boyen, Freddy Haesebrouck, Charles-Oliver Gomez-Duran, Bert Devriendt, Dominiek Maes
Summary: Mycoplasma hyopneumoniae is the primary cause of enzootic pneumonia in pigs. This study investigates the long-term immune responses induced by M. hyopneumoniae vaccination in fattening pigs. It was found that while serum antibodies decreased, T cell proliferation in response to M. hyopneumoniae stimulation continued until the end of the fattening period. There were no differences in immune responses between pigs with and without maternally derived antibodies. Further research is needed to explore the impact of natural infection on these responses.
VETERINARY RESEARCH
(2023)
Article
Veterinary Sciences
Michael Pelst, Clara Hoebart, Hilde de Rooster, Bert Devriendt, Eric Cox
Summary: Certain allergens, TLRL, IL-17A, and calcitriol have been found to modulate the secretion of CXCL8 in immortalized canine buccal epithelial cells.
VETERINARY RESEARCH
(2022)