Article
Ophthalmology
Josef Huemer, Hagar Khalid, Siegfried K. Wagner, Luke Nicholson, Dun Jack Fu, Dawn A. Sim, Praveen J. Patel, Konstantinos Balaskas, Ranjan Rajendram, Pearse A. Keane
Summary: Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) can lead to visually significant vitreous hemorrhage. Wide-field optical coherence tomography angiography (WF-OCTA) is a useful noninvasive tool for detecting and characterizing neovascularization secondary to RVO in patients.
Article
Multidisciplinary Sciences
Joon Seo Lim, Cheolwon Moon, Junyeop Lee
Summary: The presence of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC) is associated with disturbances in retinal blood flow, including reduced venous blood flow velocity and rate, as well as changes in venous diameter. SRF thickness is correlated with a decrease in venous blood flow rate, suggesting that SRF plays a role in altering retinal blood flow dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Shintaro Horie, Nobuyuki Kukimoto, Koju Kamoi, Tae Igarashi-Yokoi, Takeshi Yoshida, Kyoko Ohno-Matsui
Summary: The study found that in eyes with diabetic retinopathy, there is a high correspondence between the hyporeflective areas in widefield blue SLO images and the non-perfused areas in FA images, indicating that widefield blue SLO can be used to identify ischemic retinal areas without the need for dye injection.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ramesh Venkatesh, Shama Sharief, Chitturi Venkata Sai Prashanti, Nikitha Gurram Reddy, Rubble Mangla, Yash Parmar, Aaditi Anilkumar, Naresh Kumar Yadav, Jay Chhablani
Summary: Aberrant filling of the retinal vein in patients with branch or hemi-central retinal artery occlusions is associated with less severe retinal ischemia and better visual outcomes. This finding may be attributed to altered retinal vascular anatomy or arteriovenous shunts. The presence of aberrant filling of the retinal vein could indicate a better visual prognosis.
Article
Biochemistry & Molecular Biology
Karoline Baquet-Walscheid, Lena Wildschuetz, Maren Kasper, Martin Busch, Solon Thanos, Dirk Bauer, Monika Stoll, Simone Koenig, Arnd Heiligenhaus
Summary: This study suggests that there are differential expressions of genes and proteins related to angiogenesis in the iris tissue associated with JIAU. These differences may lead to clinically visible alterations in the iris vasculature in selected cases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Ophthalmology
Duriye Damla Sevgi, Sunil K. Srivastava, Charles Wykoff, Adrienne W. Scott, Jenna Hach, Margaret O'Connell, Jon Whitney, Amit Vasanji, Jamie L. Reese, Justis P. Ehlers
Summary: The study demonstrates the feasibility of using a deep learning-based vascular segmentation tool to extract vascular parameters for quality assessment and optimized phase selection in angiographic images. Results show successful identification of appropriate images for both early and late phases in 85.2% of sessions, indicating the effectiveness of this technology.
Article
Chemistry, Multidisciplinary
Hiroshi Keino, Tomoki Wakitani, Wataru Sunayama, Yuji Hatanaka
Summary: This study developed an automatic segmentation model using deep learning and FA images to detect retinal vascular leakage. The automated model showed high accuracy and recall in segmenting the leakage area in UWF FA images and exhibited a significant positive correlation with FA vascular leakage score.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Faruque D. Ghanchi, Corinne Fulcher, Zeid Madanat, Faris Mdanat
Summary: The study demonstrated that OCT-A has high sensitivity and specificity for detecting CNV in treatment-naive nAMD patients, and suggested the potential use of SHRM and DLS as additional biomarkers for diagnosis.
Review
Medicine, General & Internal
Aniruddha Agarwal, Anne Ruebsam, Lynn zur Bonsen, Francesco Pichi, Piergiorgio Neri, Uwe Pleyer
Summary: In this review, the etiologies, clinical manifestations, and imaging advances in retinal vasculitis, such as OCTA and widefield imaging, have been comprehensively discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jie Peng, Jianing Ren, Xuerui Zhang, Yuan Yang, Yihua Zou, Haodong Xiao, Yu Xu, Peiquan Zhao
Summary: The two-step fundus fluorescein angiography (FFA) procedure is effective in diagnosing and treating pediatric retinal vasculopathy, especially for neovascularization.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Areum Jeong, Xue Yao, Jano van Hemert, Min Sagong
Summary: This study investigates the relationship between the characteristics of non-perfusion regions and the weighted ischemic index with cytokines, macular edema, and neovascularization in diabetic retinopathy. The findings suggest that the weighted ischemic index reflecting both metabolic activity and cell distribution is more valuable in evaluating the severity and clinical features of diabetic retinopathy compared to the non-weighted index conventionally used.
SCIENTIFIC REPORTS
(2022)
Review
Biochemical Research Methods
Tristan t. Hormel, Yali Jia
Summary: Optical coherence tomography angiography (OCTA) is a high-resolution and depth-resolved imaging technique used for non-invasive imaging and quantitative analysis of retinal and choroidal vasculature, providing important biomarkers for clinical practice and therapeutic research.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ziqi Tang, Ximei Zhang, Guangqian Yang, Guanghua Zhang, Yubin Gong, Ke Zhao, Juan Xie, Junjun Hou, Jia Hou, Bin Sun, Zhao Wang
Summary: The study developed CNN methods for segmenting RNP in RVO in FA images, achieving excellent results in agreement with physicians. CNN performance was significantly improved by using the adaptive histogram-based data augmentation method. Training CNNs with averaged labels from multiple physicians resulted in the best consensus with all physicians.
Article
Computer Science, Artificial Intelligence
Javier Martinez-Rio, Enrique J. Carmona, Daniel Cancelas, Jorge Novo, Marcos Ortega
Summary: There are different retinal vascular imaging modalities widely used in clinical practice to diagnose different retinal pathologies. Joint analysis of these multimodal images is of increasing interest. A weakly supervised deep learning methodology for robust deformable registration of multimodal retinal images is presented, which is applied to register fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) images.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Multidisciplinary Sciences
Seung Hyen Lee, Eun Ji Lee, Tae-Woo Kim
Summary: This study compares the extent of microvasculature impairment in the peripapillary retina and choroid in eyes with primary open-angle glaucoma (POAG) and investigates the association between the discrepancy in microvasculature impairments and the rate of progressive retinal nerve fiber layer (RNFL) thinning. The findings suggest that a larger width of choroidal microvasculature dropout relative to retinal microvascular impairment may indicate an increased risk of faster RNFL thinning in POAG patients.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Peters Tobias, Seitz Immanuel Philipp, Michalakis Stylianos, Biel Martin, Wilhelm Barbara, Reichel Felix, Ochakovski Guy Alexander, Zrenner Eberhart, Ueffing Marius, Korbmacher Birgit, Korte Sven, Bartz-Schmidt Karl Ulrich, Fischer Manuel Dominik, Karl Ulrich Bartz-Schmidt, Sylvia Bolz, Dominik Fischer, Susanne Kohl, Laura Kuehlewein, Regine Muehlfriedel, Jonas Neubauer, Alex Ochakovski, Francois Paquet-Durand, Mathias Seeliger, Vithiyanjali Sothilingam, Marius Ueffing, Nicole Weisschuh, Bernd Wissinger, Ahmad Zhour, Ditta Zobor, Eberhart Zrenner, Martin Biel, Stylianos Michalakis, Christian Schoen, Nadine Kahle, Tobias Peters, Barbara Wilhelm, Steven Tsang, Christian Johannes Gloeckner
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2019)
Article
Cell & Tissue Engineering
Ratnesh K. Singh, Paige Winkler, Francois Binette, Randolph D. Glickman, Magdalene Seiler, Simon M. Petersen-Jones, Igor O. Nasonkin
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Ophthalmology
M. Dominik Fischer, Stylianos Michalakis, Barbara Wilhelm, Ditta Zobor, Regine Muehlfriedel, Susanne Kohl, Nicole Weisschuh, G. Alex Ochakovski, Reinhild Klein, Christian Schoen, Vithiyanjali Sothilingam, Marina Garcia-Garrido, Laura Kuehlewein, Nadine Kahle, Annette Werner, Daniyar Dauletbekov, Francois Paquet-Durand, Stephen Tsang, Peter Martus, Tobias Peters, Mathias Seeliger, Karl Ulrich Bartz-Schmidt, Marius Ueffing, Eberhart Zrenner, Martin Biel, Bernd Wissinger
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Ratnesh K. Singh, Francois Binette, Magdalene Seiler, Simon M. Petersen-Jones, Igor O. Nasonkin
Summary: Blindness caused by retinal degeneration is currently incurable, but regenerative medicine approaches have made groundbreaking discoveries in animal studies. However, the commercialization and standardization of these methods for human treatment are progressing slowly. This review outlines the potential of regenerative medicine approaches for treating blindness caused by retinal cell death.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Ophthalmology
Felix Friedrich Reichel, Stylianos Michalakis, Barbara Wilhelm, Ditta Zobor, Regine Muehlfriedel, Susanne Kohl, Nicole Weisschuh, Vithiyanjali Sothilingam, Laura Kuehlewein, Nadine Kahle, Immanuel Seitz, Francois Paquet-Durand, Stephen H. Tsang, Peter Martus, Tobias Peters, Mathias Seeliger, Karl Ulrich Bartz-Schmidt, Marius Ueffing, Eberhard Zrenner, Martin Biel, Bernd Wissinger, Dominik Fischer
Summary: The study found that the subretinal gene therapy for CNGA3-associated achromatopsia demonstrated a very good safety profile even at the highest dose administered. Functional benefits were noted in the treated eye and persisted throughout the follow-up period, but further research with larger sample sizes is needed to determine efficacy. The trial results will inform future clinical trials on the design and endpoints, with a potential focus on treating younger patients to avoid amblyopia as a limiting factor.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Yan, Alexander Guenter, Soumyaparna Das, Regine Muehlfriedel, Stylianos Michalakis, Kangwei Jiao, Mathias W. Seeliger, Francois Paquet-Durand
Summary: Inherited retinal degenerations (IRDs) are blinding diseases characterized by progressive loss of photoreceptors. The excessive activation of calpain and poly (ADP-ribose) polymerase (PARP) is associated with the pathology of IRDs. Inhibitors of these enzymes have shown promise in preventing photoreceptor cell death. However, the relationship between calpain and PARP in IRDs is still unclear. In this study, organotypic retinal explant cultures were used to investigate the effects of calpain inhibitors, PARP inhibitors, and voltage-gated Ca2+ channel (VGCC) inhibitors on cell death in IRD mice models. The results suggest that PARP acts upstream of calpain and both enzymes are part of the same degenerative pathway in Pde6b-dependent photoreceptor degeneration. Our findings highlight the potential of targeting PARP for therapeutic interventions in IRD-type diseases.
Article
Cardiac & Cardiovascular Systems
Michael M. Orlich, Rodrigo Dieguez-Hurtado, Regine Muehlfriedel, Vithiyanjali Sothilingam, Hartwig Wolburg, Cansu Ebru Oender, Pascal Woelffing, Christer Betsholtz, Konstantin Gaengel, Mathias Seeliger, Ralf H. Adams, Alfred Nordheim
Summary: This study reveals the crucial role of the transcription factor SRF in pericytes and vascular smooth muscle cells, which is essential for maintaining vascular integrity and tone.
CIRCULATION RESEARCH
(2022)
Article
Ophthalmology
Bin Lin, Bryce T. McLelland, Robert B. Aramant, Biju B. Thomas, Gabriel Nistor, Hans S. Keirstead, Magdalene J. Seiler
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Bin Lin, Bryce McLelland, Yuntian Xue, Robert Sims, Johanes Santoso, Gabriel Nistor, Robert Aramant, Andrew Browne, Hans Keirstead, Magdalene J. Seiler
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Yuntian Xue, Bryce McLelland, Gabriel Nistor, Hans Keirstead, William Tang, Magdalene J. Seiler, Andrew Browne
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Biotechnology & Applied Microbiology
S. Michalakis, L. Occelli, C. Schoen, R. Muehlfriedel, V. Sothilingam, M. W. Seeliger, M. Biel, S. Petersen-Jones
HUMAN GENE THERAPY
(2019)
Meeting Abstract
Ophthalmology
Magdalene J. Seiler, Bin Lin, Bryce McLelland, Gabriel Nistor, Robert B. Aramant, Biju Thomas, Hans Keirstead
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Susanne Kohl, Markus Burkard, Timm Kraetzig, Naoyuki Tanimoto, Britta Baumann, Martin Biel, Robert Lukowski, Mathias W. Seeliger, Stylianos Michalakis, Bernd Wissinger, Peter Ruth
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Meeting Abstract
Ophthalmology
Bin Lin, Juan Carlos Martinez, Dan Hong Zhu, David R. Hinton, Mark Humayun, Bryce McLelland, Robert Aramant, Magdalene J. Seiler, Biju Thomas
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Francois Paquet-Durand, Susanne C. Beck, Soumyaparna Das, Gesine Huber, Le Chang, Timm Schubert, Naoyuki Tanimoto, Marina Garcia-Garrido, Regine Muehlfriedel, Sylvia Bolz, Wolfgang Hoffmann, Ulrich Schraermeyer, Benjamin Mordmueller, Mathias W. Seeliger
SCIENTIFIC REPORTS
(2019)