Journal
VETERINARY MICROBIOLOGY
Volume 151, Issue 3-4, Pages 275-283Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2011.03.037
Keywords
Subgroup J avian leukosis virus; Hemangioma; Full-length proviral genome; Egg-type chicken; Layer
Categories
Funding
- NSFC-Guangdong Province of China [U0831002]
- National Broiler Industry [NYCYTX-42-G3-03]
- Science and Technology Planning Project of Guangdong Province, China [2009A0201006, 2008B02070009]
- National Natural Science Foundation of China [30771612, 30800826]
- Guangdong Natural Science Foundation [8151064201000065]
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Subgroup J avian leukosis virus (ALV-J), first isolated in 1989, predominantly causes myeloid leukosis (ML) in meat-type or egg-type chicken. Since 2006, the clinical cases of hemangioma rather than ML in commercial layer flocks associated with ALV-J have been reported, but it was still not clear whether the novel oncogenic ALV-J had emerged. We characterized SCAU-HN06 isolate of ALV-J from hemangioma in commercial Roman layers through animal experiment and full-length proviral genome sequence analysis. The SPF white leghorn egg-type chickens infected with SCAU-HN06 in ovo at day 11 of incubation showed an overall incidence of 56% hemangioma and 8% renal tumor throughout the 22-week trial, the mortality rate was 16%. Most genes of SCAU-HN06 isolate showed high nucleotide sequence identity to JS09GY6 which was isolated from Hy-Line Variety Brown layers suffering hemangioma. The 19-bp insertion in leader sequence and one key deletion in E element were the common features of SCAU-HN06 and JS09GY6. SCAU-HN06 and those ALV-Js associated with hemangioma, possibly recombinants of ALV-J and other avian retrovirus, may share the same ancestor. (C) 2011 Elsevier B.V. All rights reserved.
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