Journal
VETERINARY MICROBIOLOGY
Volume 132, Issue 3-4, Pages 260-273Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2008.05.023
Keywords
Experimental infections; Meta-analysis; Porcine circovirus type 2; Postweaning multisystemic wasting syndrome
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Funding
- Spanish Government [GEN2003-20658-C05-02]
- European Commission [513928]
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A meta-analysis was performed with the aim to identify factors with a relevant influence on the expression of clinical postweaning multisystemic wasting syndrome (PMWS) under experimental conditions. Data from 44 studies were included in the analysis. Several variables were studied: number of pigs in the experiment, intake of colostrum, serological status against porcine circovirus type 2 (PCV2), strain of PCV2 used for inoculation, the route and dose of inoculation, and use of potential triggering factors (such as co-infections, vaccinations, or immunomodulator products). Multiple correspondence analysis and log-linear regression methods were used to establish the relationships between the studied variables and the number of PCV2 infected pigs that developed PMWS. Based on the results of the meta-analysis, the most successful animal experiment aimed to develop PMWS should include: (1) colostrum-deprived pigs, (2) age of inoculation below 3 weeks, (3) high doses of PCV2 inoculum, (4) PCV2 strain from genotype 1, and (5) co-infection with another swine pathogen as a triggering factor. (C) 2008 Elsevier B.V. All rights reserved.
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