Journal
VETERINARY JOURNAL
Volume 178, Issue 2, Pages 208-213Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2007.07.030
Keywords
Dairy cattle; Mastitis Neutrophil; Parturition; Reactive oxygen species
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The periparturient period of a dairy cow is associated with increased incidence and/or severity of certain infectious diseases, including mastitis. It is believed that the heightened physiological demands of calving and initiation of milk production contribute to a state of immunosuppression during this period. Previous studies have indicated that neutrophil production of reactive oxygen species (ROS), which is a critical element of the host innate immune response to bacterial infection, is impaired in the 1-2 week period following calving. However, whether there is comprehensive inhibition of ROS production or selective inhibition of particular ROS remains unknown. The present study provides evidence that neutrophils isolated from cows (n = 20) after calving have an increased capacity to generate intracellular ROS and ail impaired ability to release extracellular superoxide anion and hydrogen peroxide. Published by Elsevier Ltd.
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