☆ 4.4 Article

Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: A pilot study

VETERINARY JOURNAL (2008)

Journal

VETERINARY JOURNAL

Volume 178, Issue 1, Pages 103-108

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/j.tvjl.2007.06.015

Keywords

Desmopressin; Canine; Mammary tumours; Metastasis

Categories

Veterinary Sciences

Funding

Morris Animal Foundation [D05CA-059]
Quilmes National University [53-A048]
National Agency for Scientific and Technological Promotion, Argentina [14255/03]

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Abstract

Desmopressin (1-deamino-8-D-arginine vasopressin, also known as DDAVP) is a safe haemostatic compound capable of inhibiting lymph node and lung metastasis in a mouse model of mammary tumour manipulation and surgical excision. The aim of this Study was to test the efficacy and safety of perioperative DDAVP (1 mu g/kg) in surgically treated bitches with mammary gland tumours (MGT). Twenty-one, otherwise healthy, intact bitches, with malignant MGT stage III or IV were randomly allocated to DDAVP (n = 11) or placebo (n = 10) groups. En bloc mastectomy of the affected gland/s was performed. DDAVP had a significant beneficial effect on disease-free period (P < 0.01) and overall survival time (P < 0.05). No side effects were seen in any of the cases. Whatever the mechanism of action, it seems that DDAVP may have a novel use in cancer surgery to minimise spread or survival of residual malignant cells. Additional, large scale controlled trials are required to fully evaluate this adjuvant pharmacological protocol. (C) 2007 Elsevier Ltd. All rights reserved.

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