Review
Immunology
Yingman Liu, Wenxuan Huang, Jiaqi Wang, Jiaojiao Ma, Manman Zhang, Xiaoying Lu, Jie Liu, Yurong Kou
Summary: Periodontal disease, considered a common inflammatory disease, is believed to contribute to the development of gastrointestinal diseases and other systemic diseases by affecting the intestinal barrier through periodontal pathogens. This review summarizes studies on the effects of periodontal pathogens on the intestinal barrier, potentially shedding light on the link between periodontitis and gastrointestinal diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin, Feng Sun, Yixin Lu
Summary: This study explored the effect of exosomes derived from Trichinella spiralis infective larvae (TsExos) on the barrier function of porcine small intestinal epithelial cells (IPEC-J2). The results showed that TsExos ingestion decreased cell viability, increased FITC-dextran content, lactate dehydrogenase and reactive oxygen species levels. TsExos also induced apoptosis, nuclear pyknosis, and nuclear rupture. In addition, TsExos disrupted tight junctions and altered gene expression.
VETERINARY RESEARCH
(2022)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jingru Guo, Jing Xu, Leichong Chen, Zhuo Chen, Huijie Hu, Junshu Nie, Jianbin Yuan, Li Ma, Jingjing Lu, Hong Ji, Bin Xu
Summary: This study revealed that chronic cold exposure damages the ileal epithelial barrier and induces endoplasmic reticulum stress. Knockout of SIRT2 alleviates ileal injury via enhanced autophagy. Autophagy can restore the expression of ZO-1 under stress.
Article
Biochemistry & Molecular Biology
Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
Summary: The study found that lactoferrin (LF) can reduce the increased intestinal permeability caused by aflatoxin M1 (AFM1) and repair the damaged intestinal barrier. In addition, the research revealed that LF acts through regulating multiple pathways related to intestinal cell survival and intestinal integrity. These findings suggest that LF may be a potential option for treating compromised intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Article
Engineering, Environmental
Yuan Cui, Qianqian Xiao, Zhenyu Wang, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei
Summary: The study found that the novel brominated flame retardant BTBPE causes damage to the intestine by activating the IRX3/NOS2 axis, leading to necroptosis and disruption of tight junctions. Blocking the IRX3/NOS2 axis can inhibit necroptosis and restore tight junctions. Additionally, BTBPE exposure also induces inflammation and loss of the mucous layer in the intestine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Environmental Sciences
Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen, Qing Wang
Summary: Micro/nano-plastics (MPs/NPs) can induce intestinal toxicity by increasing permeability and decreasing tight junction proteins expression. The expression of MUC2 is elevated in response to 20 nm PS-NPs, alleviating their cytotoxicity. HO1/p38/IL-10 pathway plays a role in the regulation of MUC2 expression. This study provides valuable insight into the mechanism and potential risk of intestinal toxicity induced by nanoplastics.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Agriculture, Multidisciplinary
Yunika Mayangsari, Natsumi Sugimachi, Wenxi Xu, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study demonstrated that 3,5,7,3',4'- pentamethoxyflavone (PMF) can enhance the intestinal tight junction (TJ) barrier integrity by regulating the transcription of TJ proteins, such as occludin, claudin-3, and claudin-4.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yanli Li, Jie Liu, Pawin Pongkorpsakol, Zhengguo Xiong, Li Li, Xuemei Jiang, Haixia Zhao, Ding Yuan, Changcheng Zhang, Yuhui Guo, Yaoyan Dun
Summary: This study explores the potential therapeutic effects of Icariin (ICA) on inflammation-associated intestinal barrier function impairment in aging. The results show that ICA can alleviate the down-regulation of tight junctions and reduce the expression of inflammatory cytokines. It is also found that ICA exerts its effects by suppressing oxidative stress and decreasing miR-122a expression. These findings suggest that ICA may have a protective effect on intestinal barrier function and could be a potential treatment for colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Saad Gilani, Peter Chrystal, Reza Barekatain
Summary: Maintaining and optimizing intestinal barrier function in poultry is crucial for bird health and performance, with intestinal permeability mainly controlled by tight junction proteins. Disruption of these proteins can lead to gut leakage, bacterial translocation, inflammation, and compromised health in birds. Research on intestinal permeability in broiler chickens is still limited, but nutrition modulation may offer promising outcomes for improving poultry health and performance.
Article
Biotechnology & Applied Microbiology
Yan Tian, Ruo Shu, Yi Lei, Yu Xu, Xinfeng Zhang, Huayou Luo
Summary: In the process of ischemia-reperfusion injury, intestinal ischemia and inflammation intertwine, leading to tissue damage. However, somatostatin can protect against intestinal epithelial barrier dysfunction caused by reperfusion, and its mechanism involves upregulation of Tollip and inhibition of TLR2/MyD88/NF-κB signaling.
Article
Physiology
Eriko Kage-Nakadai, Simo Sun, Satoru Iwata, Sawako Yoshina, Yoshikazu Nishikawa, Shohei Mitani
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2019)
Article
Agriculture, Dairy & Animal Science
S. N. Magray, S. A. Wani, Z. A. Kashoo, M. A. Bhat, S. Adil, S. Farooq, M. A. Rather, Z. A. Kabli, M. T. Banday, Y. Nishikawa
ANIMAL PRODUCTION SCIENCE
(2019)
Article
Biotechnology & Applied Microbiology
Md Shafiullah Parvej, Hiromi Nakamura, Md Ashraful Alam, Lili Wang, Shaobo Zhang, Kazuo Emura, Eriko Kage-Nakadai, Takayuki Wada, Yukiko Hara-Kudo, Yoshikazu Nishikawa
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Immunology
Yoshihiko Tanimoto, Sayaka Tamai, Takehiro Matsuzaki, Narumi Takeuchi, Takumi Noju, Saki Yanagida, Eriko Kage-Nakadai, Yoshihiro Yamaguchi, Toshio Kodama, Shota Nakamura, Daisuke Motooka, Tetsuya Iida, Yoshikazu Nishikawa
INFECTION AND IMMUNITY
(2019)
Article
Neurosciences
Simo Sun, Akane Ohta, Atsushi Kuhara, Yoshikazu Nishikawa, Eriko Kage-Nakadai
NEUROSCIENCE RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Chien-Sen Liao, Yong-Han Hong, Yoshikazu Nishikawa, Eriko Kage-Nakadai, Tai-Ying Chiou, Chien-Chang Wu
Article
Geriatrics & Gerontology
Ai Ito, Quichi Zhao, Yoichiro Tanaka, Masumi Yasui, Rina Katayama, Simo Sun, Yoshihiko Tanimoto, Yoshikazu Nishikawa, Eriko Kage-Nakadai
Summary: Metolazone has been identified as a drug that extends the lifespan of C. elegans by activating UPRmt. It upregulates mitochondrial chaperone proteins and has a specific mode of action, as shown in HeLa cell lines.
Article
Biotechnology & Applied Microbiology
R. Katayama, Y. Matsumoto, Y. Higashi, S. Sun, H. Sasao, Y. Tanimoto, Y. Nishikawa, E. Kage-Nakadai
Summary: This study showed that Bacillus subtilis (natto) can enhance the resistance of Caenorhabditis elegans to gram-positive bacteria and increase the survival time of the worms upon infection. Transcriptome analysis revealed the upregulation of genes associated with immunity and defense response in B. subtilis (natto)-fed worms.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yoshihiko Tanimoto, Miyoko Inoue, Kana Komatsu, Atsuyuki Odani, Takayuki Wada, Eriko Kage-Nakadai, Yoshikazu Nishikawa
Summary: The study found that E. coli expressing K88(O169) adhesin can infect different hosts including pigs and cattle, with the first report of domestic livestock having antibodies to K88(O169) of human ETEC; suggesting zoonotic strains may hide among human ETEC organisms, calling for the adoption of the One Health concept to intervene in ETEC infections among animals and humans.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Microbiology
Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai
Summary: This study investigated the effects of different Cutibacterium acnes strains on the life span of Caenorhabditis elegans and host resistance against Staphylococcus aureus. It was found that certain strains of C. acnes could shorten the life span of C. elegans, while others, like strain HL110PA4, did not alter it. Additionally, it was discovered that the TIR-1 and p38 MAPK pathways play a role in conferring host resistance against S. aureus in a C. acnes-mediated manner.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Tomomi Komura, Asami Takemoto, Hideki Kosaka, Toshio Suzuki, Yoshikazu Nishikawa
Summary: This study revealed the anti-aging effects of Lactococcus cremoris subsp. cremoris strain FC through the SKN-1/Nrf2 pathway, and its beneficial effects on perception and inhibition of AGEs in nematodes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, Research & Experimental
Tomomi Komura, Motoshi Aoki, Satoshi Kotoura, Yoshikazu Nishikawa
Summary: The accumulation of amyloid-beta protein in the brain is a key factor in Alzheimer's disease, and it can be inhibited by certain strains of lactic acid bacteria (LAB). In this study, two strains of LAB, Lactococcus laudensis (LL) and Pediococcus parvulus (PP), were found to prevent the toxicity of A beta accumulation and alleviate neurotoxicity in AD model worms. This research suggests that LAB could be a potential preventive method for Alzheimer's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Tomomi Komura, Mikihiro Yamanaka, Kohji Nishimura, Keita Hara, Yoshikazu Nishikawa
Summary: Autofluorescence can be used as a noninvasive biomarker of senescence in Caenorhabditis elegans. The fluorescence of individual nematodes increases with age, with worms exhibiting lower fluorescence having longer life expectancy. Glycated substances contribute to the increase in fluorescence, making it a useful biomarker for AGEs.
NPJ AGING AND MECHANISMS OF DISEASE
(2021)
Article
Infectious Diseases
Md Shafiullah Parvej, Md Ashraful Alam, Mio Shono, Nusrat Zahan, Misrat Masuma Parvez, Wahedul Karim Ansari, Md Sayduzzaman Jowel, Md Sharif Uddin, Eriko Kage-Nakadai, Md Tanvir Rahman, Yoshikazu Nishikawa
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Microbiology
Simo Sun, Yasuko Mizuno, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai
BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH
(2019)
