Article
Agriculture, Dairy & Animal Science
Marco Pietra, Giorgia Galiazzo, Francesca Bresciani, Maria Morini, Sara Licarini, Maria Elena Turba, Gianmaria Amaducci, Giuliano Bettini, Federico Fracassi, Fabio Ostanello
Summary: This study aimed to identify factors related to therapeutic failure in canine chronic enteropathies, with a focus on P-glycoprotein activity. Factors such as glucocorticoid treatment and hypoproteinemia were associated with a higher risk of being in the non-responsive group. Clonality testing showed a potential link to undiagnosed lymphoma in non-responsive dogs. More research is needed to understand the mechanisms behind non-responsive enteropathy and its potential association with neoplastic diseases.
Article
Veterinary Sciences
Federica Riva, Laura Bianchessi, Camilla Recordati, Alessia Inglesi, Vittoria Castiglioni, Lauretta Turin
Summary: Chronic enteropathy is a severe gastrointestinal disease in dogs driven by poorly understood inflammatory pathways. This study found that IL-1R8, an inflammatory response regulator, is downregulated in dogs with CE, especially those with Helicobacter spp. infection. The expression level of IL-1R8 correlates with the severity of macroscopic lesions identified by endoscopy. Furthermore, IL-1R8 expression level is associated with dog breed.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Veronica Marchetti, Eleonora Gori, Valeria Mariotti, Angelo Gazzano, Chiara Mariti
Summary: The study evaluated the impact of canine chronic enteropathies on dogs' quality of life, behavior, and owner-dog relationship. Dogs with chronic enteropathies had lower QoL compared to healthy dogs and cancer patients, but showed improvement in general QoL, health QoL, and interaction QoL during follow-up. Higher levels of attachment between owner and dog were found in dogs affected by chronic enteropathies, with changes in behaviors observed.
VETERINARY SCIENCES
(2021)
Article
Veterinary Sciences
Alison C. Manchester, Steven Dow, Lyndah Chow, Jason Gagne, Michael R. Lappin
Summary: Exclusive feeding of an amino acid-based kibble (EL) improved clinical signs in dogs with chronic enteropathy (CE), and the changes in fecal microbiome were associated with the response to the diet.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
David Diaz-Reganon, Mercedes Garcia-Sancho, Alejandra Villaescusa, Angel Sainz, Beatriz Agulla, Mariana Reyes-Prieto, Antonio Rodriguez-Bertos, Fernando Rodriguez-Franco
Summary: Chronic inflammatory enteropathies are a common cause of chronic vomiting and diarrhea in dogs. This study aimed to characterize the intestinal bacterial microbiota in dogs with inflammatory bowel disease (IBD) using duodenal biopsies and fecal samples, and compare them to healthy dogs. The results showed significant differences in the gut microbiota of dogs with IBD compared to healthy dogs, with more pronounced changes in the fecal microbiota. Further investigations are needed to understand the functionality of the gut microbiome in canine IBD.
Article
Gastroenterology & Hepatology
Federica Branchi, Jakob Johann Wiese, Claudia Heldt, Subhakankha Manna, Violaine Dony, Christoph Loddenkemper, Christian Bojarski, Britta Siegmund, Thomas Schneider, Severin Daum, Michael Hummel, Verena Moos, Michael Schumann
Summary: This study investigated the associations between clinical characteristics of refractory celiac disease patients and aberrant intraepithelial lymphocytes, and evaluated the accuracy of immunophenotyping for identifying high-risk refractory celiac disease. The results showed that flow cytometry analysis is a good predictor for high-risk refractory celiac disease, and adding the evaluation of malabsorption to the diagnostic assessment improves accuracy.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Pharmacology & Pharmacy
Meiling Liu, Kang Wu, Jinduan Lin, Qingqiang Xie, Yuan Liu, Yin Huang, Jun Zeng, Zhaogang Yang, Yifan Wang, Shiyan Dong, Weiye Deng, Mingming Yang, Song Wu, Wen Jiang, Xuefeng Li
Summary: COPD is a global disease with complex causes, where the immune system plays a key role in inflammation. IL-17A is involved in the development of COPD through multiple signaling pathways, making it a potential novel therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Elettra Febo, Paolo Emidio Crisi, Sergio Oddi, Marco Pietra, Giorgia Galiazzo, Fabiana Piscitelli, Alessandro Gramenzi, Roberta Di Prinzio, Morena Di Tommaso, Nicola Bernabo, Tiziana Bisogno, Mauro Maccarrone, Andrea Boari
Summary: The study showed that endocannabinoid signaling is altered in canine CEs, and different subtypes of CE showed distinct profiles of circulating 2-AG, PEA, and OEA plasma levels, indicating that these circulating bioactive lipids may have the potential to become candidate biomarkers for canine CEs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Sonia Kiran, Vijay Kumar, E. Angela Murphy, Reilly T. Enos, Udai P. Singh
Summary: Obesity is a powerful health indicator that leads to metabolic diseases, insulin resistance, and low-grade chronic inflammation. Research has shown that obese tissues activate and induce CD4(+) and CD8(+) CD69(+) T cells, increase the expression of CXCR3 receptors, and promote recruitment and accumulation of pro-inflammatory M1 macrophages to maintain low-grade chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Dipak Kumar Sahoo, Karin Allenspach, Jonathan P. Mochel, Valerie Parker, Adam Joseph Rudinsky, Jenessa A. Winston, Agnes Bourgois-Mochel, Mark Ackermann, Romy M. Heilmann, Gabor Koeller, Lingnan Yuan, Tracey Stewart, Shannon Morgan, Kaitlyn R. Scheunemann, Chelsea A. Iennarella-Servantez, Vojtech Gabriel, Christopher Zdyrski, Rachel Pilla, Jan S. Suchodolski, Albert E. Jergens
Summary: Chronic inflammatory enteropathy (CE) is a common cause of persistent gastrointestinal signs and intestinal inflammation in dogs. This study aimed to investigate the effects of the synbiotic-IgY supplement on clinical signs, inflammatory indices, and mucosal microbiota in dogs with CE. Results indicated that dogs administered the supplement showed decreased levels of inflammatory markers, increased numbers of beneficial bacteria, and decreased numbers of harmful bacteria, suggesting a beneficial effect of the supplement on dogs with CE.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Lanlan Xiao, Shima Tang, Lingjian Zhang, Shanshan Ma, Yalei Zhao, Fen Zhang, Zhongyang Xie, Lanjuan Li
Summary: The study demonstrates that serum CXCL1 can serve as a biomarker for indicating the severity and prognosis of HBV-ACLF patients, showing correlation with neutrophil count and organ failure.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria-Adriana Neag, Carmen-Stanca Melincovici, Adrian Catinean, Dana-Maria Muntean, Raluca-Maria Pop, Ioana-Corina Bocsan, Andrei-Otto Mitre, Mihai-Bogdan Cardos, Andreea-Ioana Inceu, Anca-Dana Buzoianu
Summary: The study suggests that modulation of gut microbiota through administration of probiotics, immunoglobulins, and amino acids could be an effective therapy for preventing NSAID-induced enteropathy.
Article
Veterinary Sciences
Marin Hirokawa, Kaho Takahashi, Masaki Miyajima, Rintaro Furukawa, Koji Sugita, Hirotaka Kondo, Keitaro Ohmori
Summary: Inflammasomes may play a role in canine chronic enteropathy, with NLRP3 and NLRP12 potentially contributing to colitis in dogs with food-responsive enteropathy.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Albert Frank Magnusen, Reena Rani, Mary Ashley McKay, Shelby Loraine Hatton, Tsitsi Carol Nyamajenjere, Daniel Nii Aryee Magnusen, Joerg Koehl, Gregory Alex Grabowski, Manoj Kumar Pandey
Summary: Gaucher disease is a lysosomal storage disease caused by mutations in GBA1/Gba1. Deficiency of lysosomal acid beta-glucosidase enzyme leads to abnormal accumulation of glucosylceramide, resulting in altered function of immune cells and tissue damage. The study reveals the role of CXCR3 receptor and CXCL9 chemokine in increased recruitment of T cells in Gaucher disease, suggesting potential therapeutic targets for inflammation treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Muttiah Barathan, Behnaz Riazalhosseini, Thevambiga Iyadorai, Kumutha Malar Vellasamy, Jamuna Vadivelu, Li-Yen Chang, Ahmad Khusairy Zulpa, Marie Larsson, Esaki M. Shankar, Rosmawati Mohamed
Summary: In chronic HBV patients, those with liver cirrhosis showed higher levels of oxidative stress and cell apoptosis, as well as alterations in inflammatory mediators.
MICROBIAL PATHOGENESIS
(2021)
Article
Pathology
Shingo Maeda, Ryohei Yoshitake, James K. Chambers, Kazuyuki Uchida, Shotaro Eto, Namiko Ikeda, Takayuki Nakagawa, Ryohei Nishimura, Yuko Goto-Koshino, Tomohiro Yonezawa, Yasuyuki Momoi
Summary: Regulatory T cells recruitment in canine urothelial carcinoma is associated with the BRAF(V595E) mutation and tumor-produced CCL17. Elevated CCL17 mRNA expression in bladder and increased CCL17 protein concentration in urine were found in dogs with urothelial carcinoma. The presence of higher levels of tumor-infiltrating regulatory T cells and urine CCL17 concentration were correlated with a poor prognosis in these dogs.
VETERINARY PATHOLOGY
(2021)
Article
Veterinary Sciences
Juraj Hlavaty, Reinhard Ertl, Tewodros Abere Mekuria, Barbara Ruetgen, Hajime Tsujimoto, Ingrid Walter, Birgitt Wolfesberger
Summary: The use of prednisolone prior to chemotherapy in small animal lymphoma patients negatively affects the susceptibility of lymphoma cells to doxorubicin or vincristine treatment, leading to increased expression of multidrug resistance proteins.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
A. Tani, Y. Saegusa, K. Ogawa, H. Tomiyasu, Y. Takeuchi, K. Harada, T. Kobayashi, A. Setoguchi, J. Nakamichi, T. Mizuno, M. Irie, M. Tokita, K. Fujita, M. Suenaga, T. Motegi, A. Ohmi, Y. Goto-Koshino, K. Ohno, H. Tsujimoto
Summary: Six genes associated with resistance to drugs used in CHOP-based protocol in canine lymphoma were identified in this study, and a novel scoring system to predict resistance to these drugs was proposed. This system may aid in selecting the most appropriate chemotherapy protocol for individual dogs with lymphoma.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: The study showed that continuous l-asparaginase administration is an effective and safe treatment option for dogs with large cell lymphoma of presumed GI origin. Most cases showed improvement in clinical signs at diagnosis, with a good treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Kazushi Azuma, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Hiroyuki Namba, Masahiko Nagata, Eiji Nagamine, Kazumi Nibe, Mitsuhiro Irie, Hajime Tsujimoto
Summary: Canine cutaneous lymphoma, primarily of T-cell origin, is classified into epitheliotropic and nonepitheliotropic subtypes, each with distinct histological subtypes. Prognosis is influenced by histopathological subtype, clinical variables such as neoplastic lymphocytes in peripheral blood and treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Jared A. Jaffey, Rachael Kreisler, Kate Shumway, Yan-Jane Lee, Chung-Hui Lin, Lawren L. Durocher-Babek, Kyoung-Won Seo, Hojung Choi, Ko Nakashima, Hiromi Harada, Hideyuki Kanemoto, Lee-Shuan Lin
Summary: The higher the developmental stage of GBM, the more likely it is to exhibit biliary tract related clinical signs. The nadir SBP value deserves further investigation as a prognostic or potentially modifiable variable, particularly in the presence of gallbladder rupture.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: This study examined severe adverse reactions in cats after vaccination, and found that a significant percentage experienced anaphylaxis, with a high mortality rate. Analysis of commercially available feline vaccines detected high levels of bovine serum albumin, which may be related to the occurrence of anaphylactic reactions.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Takuro Nagahara, Koichi Ohno, Itsuma Nagao, Taisuke Nakagawa, Yuko Goto-koshino, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: Intestinal lymphangiectasia (IL) is a common complication in dogs. This study aimed to investigate the potential role of inducible nitric oxide synthase (iNOS) in the development of IL in dogs with lymphoplasmacytic enteritis (LPE). The results showed that there was a significant increase in iNOS expression in the duodenal tissues of dogs with IL-negative or IL-positive LPE compared to control dogs. However, there was no significant difference in iNOS expression between IL-positive and IL-negative tissues, suggesting that factors other than nitric oxide may contribute to the development of IL in dogs with LPE.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Aki Ohmi, Miho Tanaka, Jun Rinno, Masaya Tsuboi, James K. Chambers, Kazuyuki Uchida, Yuko Goto-Koshino, Hirotaka Tomiyasu, Koichi Ohno, Hajime Tsujimoto
Summary: Lymphoma with Mott cell change (MCL) is a rare variant of canine lymphoma. This study investigated the clinical characteristics and outcomes of MCL in miniature dachshunds, and found that MCL mainly occurs in the gastrointestinal tract of these dogs and has a longer survival compared to other types of lymphoma.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Hideyuki Kanemoto, Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
Summary: This multicentre, retrospective observational study aimed to describe the clinical presentation, diagnostic methods, treatment and outcomes of cats with tracheal masses. Lymphoma was the most prevalent diagnosis, and showed a good response to chemotherapy with or without radiation therapy. Ultrasound-guided fine-needle biopsy and cytology are good diagnostic procedures for cervical tracheal lesions.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Veterinary Sciences
Mona Uchida, Yuki Matsumiya, Masaya Tsuboi, Kazuyuki Uchida, Takayuki Nakagawa, Wataru Fujii, Tetsuya Kobayashi, Hajime Tsujimoto, Aki Ohmi, Hirotaka Tomiyasu, Tomoki Motegi, Shingo Maeda, Yasuyuki Momoi, Tomohiro Yonezawa
Summary: Histiocytic sarcoma (HS) is a rare malignancy in dogs, with poor prognosis. This study investigated the involvement of apoptosis inhibitor of macrophage (AIM) in the development of HS in dogs. The expression of AIM in tumor tissue and serum AIM levels were evaluated, and the effects of AIM overexpression on HS cells were studied. The results suggest that elevated expression of AIM in tumor and serum could induce the progression of HS cells in dogs, and serum AIM levels may serve as a biomarker for HS.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Megumi Yoshida, Keijiro Mizukami, Masaharu Hisasue, Ichiro Imanishi, Keigo Kurata, Masaki Ochiai, Masato Itoh, Tadahiro Nasukawa, Jumpei Uchiyama, Hajime Tsujimoto, Masahiro Sakaguchi
Summary: A study examined severe adverse reactions after rabies vaccination in dogs in Japan, finding a low rate of anaphylaxis but a higher death rate. Veterinarians should be prepared to handle vaccine-associated anaphylaxis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Mitsuhiro Irie, Hirotaka Tomiyasu, Hajime Tsujimoto, Chiaki Kita, Yumiko Kagawa
Summary: This study investigated the overall survival and prognostic factors for dogs with GIST treated by surgical resection alone, finding that primary tumor site, particularly tumors in the small intestine, was a significant factor associated with shorter overall survival in these cases.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Pathology
Yuki Morinaga, Masaya Igase, Takuma Yanase, Yusuke Sakai, Hiroki Sakai, Aki Fujiwara-Igarashi, Hajime Tsujimoto, Masaru Okuda, Takuya Mizuno
Summary: The elevated expression of DEPDC1B in canine lymphoma suggests its potential as a marker or therapeutic target for canine malignancies. However, the exact oncogenic mechanism remains unknown.
JOURNAL OF COMPARATIVE PATHOLOGY
(2021)
Article
Veterinary Sciences
Aki Ohmi, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Taisuke Nakagawa, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: In Japan, there is an increasing incidence of gastrointestinal adenocarcinomas in Jack Russell Terriers (JRTs) compared to other breeds, with JRTs showing longer survival times and requiring different treatment strategies.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)