Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 136, Issue 1-2, Pages 133-137Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2010.02.010
Keywords
Bovine; Gamma delta T cell; Mycobacterium bovis; IFN gamma
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC)
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BCG vaccination of neonatal calves induces significant protection against bovine tuberculosis. The enhanced protection observed in neonatal calves may be linked to an enhanced capacity for IFN gamma production by innate cells, including WC1(+) gamma delta T cells, which constitute a major population in young cattle. Intranasal BCG vaccination of mice induces high levels of IFIN gamma in the lungs, which may enhance protection against subsequent challenge with virulent strains of mycobacteria. We used an intranasal BCG vaccination model in calves to study the effect on the distribution of WC1(+) gamma delta T cells expressing two alternate forms of WC1: WC1.1 and WC1.2. These subsets of WC1(+) gamma delta T cells have previously been shown to have a differential capacity for IFN gamma secretion. Our results indicate that there is a selective expansion/recruitment of gamma delta T cells expressing the IFN gamma-associated WC1.1 isoform in tissues of the lungs and upper respiratory tract following intranasal BCG vaccination. (C) 2010 Elsevier B.V. All rights reserved.
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