Article
Dermatology
Lie Choi, Alex Cook, Crystal Phuan, Aaron Martin, Sam Yang, Derrick Aw, Nisha Suyien Chandran
Summary: In this study, patients using lower doses of ciclosporin showed slower but well-tolerated response, with minimal renal impairment. The greatest control of disease was observed at 6 months.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Review
Pharmacology & Pharmacy
C. A. J. Michielsens, M. E. van Muijen, L. M. Verhoef, J. M. P. A. van den Reek, E. M. G. J. de Jong
Summary: Biologic tapering appears to be effective and safe in psoriasis patients with stable low disease activity or clinical remission. More research is needed to address the current gaps in knowledge, particularly in terms of tapering criteria and strategies, long-term safety, predictors for successful tapering, cost-effectiveness, and evaluation of newer generation biologics.
Article
Multidisciplinary Sciences
Ryo Kamata, Yukiko Okawa, Yuto Hamaguchi, Soma Tabata, Masanori Terasaki, Kazuki Takeda
Summary: This study confirmed the reactivity of mice to skin sensitizing substances and proposed a new protocol (Protocol 2) for a relatively simple skin sensitization test. Compared to other protocols and a local lymph node assay, Protocol 2 showed more pronounced skin inflammation, immune responses, and cell proliferation in auricular lymph nodes.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Mark Abie Horowitz, Sameer Jauhar, Sridhar Natesan, Robin M. Murray, David Taylor
Summary: The process of stopping antipsychotics may lead to relapse, related to neuroadaptations that persist after cessation. It is suggested to taper medications gradually over months or years and in a hyperbolic manner to reduce the risk of relapse. This approach should be tested in randomized controlled trials to evaluate its effectiveness.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Kanako Nakayama, Hiroe Tetsu, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Summary: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. This study investigated the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs) in AD. The results revealed that attenuated contact hypersensitivity (CHS) responses in AD may be hapten-independent and the tolerogenic phenotype of hapten-bearing DCs can contribute to reduced T-cell proliferation and CHS responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Eva Sanchez Armengol, Aletta Blanka Kerezsi, Flavia Laffleur
Summary: Textile production is one of the most polluting industries worldwide, with chemical waste products posing risks to human health. Medical textiles, such as sutures and dressings, are being developed to aid in patient diagnosis, therapy, and recovery. The future of smart textiles in the medical field holds promising advancements for patient care and treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Anna-Lea R. Diggelmann, Marco Baron Toaldo, Rima N. Bektas, Etienne Furthner, Iris M. Reichler, Annette P. N. Kutter
Summary: A study was conducted on 6 cats to evaluate the effects of high-dose medetomidine and its reversal with atipamezole on cardiovascular variables. The results showed that the use of atipamezole completely reversed the sedation effect and restored cardiovascular variables to normal levels, and no significant cardiac muscle damage was detected.
Article
Dermatology
Kevin Phan, Olivia Charlton, Chris Baker, Peter Foley, Saxon D. Smith
Summary: 22% of respondents never prescribe CsA, and 50% prescribe it only 1-2 times per month. Although most dermatologists consider CsA to be effective, there are concerns regarding the safety profile.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Mariana Silva Almeida, Shohei Shibagaki, Satoko Tahara-Hanaoka, Shiro Shibayama, Akira Shibuya
Summary: The study found that Allergin-1 is highly expressed in dermal dendritic cells and mice deficient in Allergin-1 exhibited exacerbated symptoms in type 2 contact hypersensitivity, while showing no significant impact on type 1 reaction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Respiratory System
Keisuke Anan, Yuki Kataoka, Kazuya Ichikado, Kodai Kawamura, Takeshi Johkoh, Kiminori Fujimoto, Kazunori Tobino, Ryo Tachikawa, Hiroyuki Ito, Takahito Nakamura, Tomoo Kishaba, Minoru Inomata, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa, Yosuke Yamamoto
Summary: This study investigated the association between early corticosteroid dose tapering and in-hospital mortality in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). The results showed that early tapering was associated with a favorable prognosis.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
William R. Swindell, Krzysztof Bojanowski, Ratan K. Chaudhuri
Summary: This study evaluated the efficacy and mechanisms of two plant-derived oil derivatives in AD-like tissue culture models. The findings showed that these compounds can prevent cytokine-induced disruption of the epidermal barrier and have anti-inflammatory and anti-itching effects. Additionally, they can regulate the expression of differentiation genes in skin cells. These results support further research and development of IDL and IDC as therapeutic candidates for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Alicia Agnoli, Guibo Xing, Daniel J. Tancredi, Elizabeth Magnan, Anthony Jerant, Joshua J. Fenton
Summary: Among patients prescribed stable, long-term, higher-dose opioid therapy, tapering events were significantly associated with increased risk of overdose and mental health crisis. The study suggests that reducing opioid doses may lead to negative outcomes such as overdose and mental health crisis.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Agriculture, Dairy & Animal Science
Keisuke Sugimoto, Kazutoshi Sugita, Kensuke Orito, Yoko Fujii
Summary: This study investigated the pharmacodynamics of repeated and multiple-dose pimobendan in healthy cats. The results showed that repeated doses of pimobendan increased cardiac systolic function and there were significant correlations between cardiac function and plasma concentrations of pimobendan and ODMP. These findings highlight the effectiveness of a higher dose of pimobendan.
Article
Psychiatry
Chen-Chung Liu, Ming H. Hsieh, Yi-Ling Chien, Chih-Min Liu, Yi-Ting Lin, Tzung-Jeng Hwang, Hai-Gwo Hwu
Summary: This study aimed to depict and subgroup the trajectories of patients undergoing guided dose reduction and explore factors associated with different dose-reduction patterns. The results showed that the dose-reduction process is dynamic and varies between individuals. Different patients have different ways and effects of reducing medication dosages. Doctors need to choose the appropriate dose reduction method based on the specific situation of each patient.
EUROPEAN PSYCHIATRY
(2023)
Article
Veterinary Sciences
Aiden P. Foster
Summary: The aim of this article is to provide an overview of common skin conditions in livestock species, including ectoparasites, immune-mediated disease, and allergic dermatitis. It emphasizes the importance of thorough clinical examination, differential diagnosis, and appropriate diagnostic testing before treatment. The article also discusses the use of topical antimicrobial therapies and the potential risks of anthelmintic resistance.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2023)