Article
Biochemistry & Molecular Biology
Nico Hartmann, Maria Knierim, Wiebke Maurer, Nataliya Dybkova, Gerd Hasenfuss, Samuel Sossalla, Katrin Streckfuss-Boemeke
Summary: In heart failure and atrial fibrillation, a persistent Na+ current (I-NaL) exerts detrimental effects on cellular electrophysiology and can induce arrhythmias. Na(V)1.8 contributes to arrhythmogenesis by inducing I-NaL. Mutations in the SCN10A gene (Na(V)1.8) are associated with increased risk for arrhythmias, Brugada syndrome, and sudden cardiac death. The mediation of these Na(V)1.8-related effects is still a subject of controversial discussion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Baozhen Qi, Shimo Dai, Yu Song, Dongli Shen, Fuhai Li, Lanfang Wei, Chunyu Zhang, Zhenning Nie, Jiaxiong Lin, Lidong Cai, Junbo Ge
Summary: Na(V)1.8 blockade in ganglionated plexi increases the incidence of ventricular arrhythmias in acute myocardial infarction hearts, suggesting a potential role of Na(V)1.8 in regulating ventricular arrhythmogenesis. Further investigation is needed to elucidate the mechanism by which Na(V)1.8 impacts on ventricular electrophysiology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Sina Safabakhsh, Pankaj Panwar, Scott Barichello, Sarabjit S. Sangha, Paul J. Hanson, Filip Van Petegem, Zachary Laksman
Summary: Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with increased morbidity and mortality. The post-translational modification of proteins, especially protein phosphorylation, may explain how risk factors lead to AF. Mass spectrometry (MS) is a common and highly resolute technique for studying protein phosphorylation, and future research utilizing MS technology aims to better understand the role of phosphorylation in the pathophysiology of AF.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Daniel Gratz, Alexander J. Winkle, Seth H. Weinberg, Thomas J. Hund
Summary: Bayesian statistics methods were used to capture variability in experimental measurements of human atrial Na(v)1.5, leading to the establishment of a novel model that incorporated physiological distribution of model parameters. Model validation was conducted by comparing simulated and experimental measurements of action potential upstroke velocity, with plans to extend the approach to other atrial ion channels for a comprehensive model of human atrial action potential.
Article
Cardiac & Cardiovascular Systems
Loryn J. Bohne, Hailey J. Jansen, Tristan W. Dorey, Irene M. Daniel, K. Lockhart Jamieson, Darrell D. Belke, Megan D. Mcrae, Robert A. Rose
Summary: This study demonstrates that GLP-1 and its analogues can reduce the incidence of atrial fibrillation and prevent atrial remodeling in patients with type 2 diabetes.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Cell Biology
Jin Ma, Qiuxiong Chen, Shiyu Ma
Summary: Atrial fibrillation (AF) is strongly associated with atrial fibrosis, which plays a crucial role in the arrhythmogenic substrate and treatment of AF. Clinical evaluation methods and prevention options for atrial fibrosis are key factors in managing AF.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Physiology
Simon Loose, Annette Lischka, Samuel Kuehs, Carla Nau, Stefan H. Heinemann, Ingo Kurth, Enrico Leipold
Summary: This article reports a rare missense mutation in SCN10A gene, resulting in functional changes of the Na(V)1.8 channel, which is associated with abnormal thermoregulation, sensory abnormalities, and excessive sweating in the patient. Through current-clamp and voltage-clamp recordings, it was found that the mutation alters the voltage dependence of channel activation and inactivation, broadens the action potentials of sensory neurons, and increases their firing rates. Therefore, it is suggested that Na(V)1.8 p.V1287I variant has a gain-of-function effect at the cellular level and contributes to the patient's symptoms.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Physiology
S. Pagani, L. Dede', A. Frontera, M. Salvador, L. R. Limite, A. Manzoni, F. Lipartiti, G. Tsitsinakis, A. Hadjis, P. Della Bella, A. Quarteroni
Summary: A novel computational approach is proposed to predict the induction and sustainment of atrial fibrillation by setting a parametrization based on conduction velocities. Substrate characteristics play a key role in inducing and sustaining these arrhythmias, with localized reentries being less frequent and stable in paroxysmal AF and anchoring themselves in areas of slow conduction in persistent AF.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Felix K. Wegner, Lucas Plagwitz, Florian Doldi, Christian Ellermann, Kevin Willy, Julian Wolfes, Sarah Sandmann, Julian Varghese, Lars Eckardt
Summary: Machine learning has great potential in medicine, particularly in the detection and management of cardiovascular diseases such as atrial fibrillation. By utilizing machine learning technologies, patient care and clinical outcomes can be substantially improved, aiding cardiologists in the management of patients with atrial fibrillation.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Biology
Miguel Rodrigo, Mahmood Alhusseini, Albert J. Rogers, Chayakrit Krittanawong, Sumiran Thakur, Ruibin Feng, Prasanth Ganesan, Sanjiv M. Narayan
Summary: This study used deep learning to analyze electrogram features and accurately classify atrial fibrillation (AF) and atrial tachycardia (AT). The results showed that deep learning could explain the diagnosis by controlling variations in shape, rate, and timing, and identify specific electrogram shapes as the fingerprint of AF. This research is important for further investigating differences in features among subpopulations of AF patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Summary: In this study, the cryo-EM structures of human Na(V)1.6/beta 1/beta 2 alone and complexed with 4,9-ah-TTX were determined, providing insights into the molecular mechanism of Na(V)1.6 inhibition and ion conductance.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Meng-ting Li, Ya-ya Du, Fei Zhong, Jie-ru Wang, You-wei Gu, Yue Zhang, Xuan-tong Huang, Yi-zhou Deng, Zheng-xin Xu
Summary: Aloperine (ALO), a quinolizidine alkaloid from Sophora alopecuroides L., has anti-arrhythmic effects on ventricular arrhythmia, partially attributed to the inhibition of peak sodium current density of voltage-gated Na+ channel currents (I-Na).
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Cell Biology
Nolan M. Dvorak, Cynthia M. Tapia, Timothy J. Baumgartner, Jully Singh, Fernanda Laezza, Aditya K. Singh
Summary: This study reveals the selective modulatory effects of Wee1 kinase inhibitor on Na(v)1.2 channel activity, emphasizing the importance of cellular signaling pathways in fine-tuning neuronal excitability.
Review
Gastroenterology & Hepatology
Bert Vandenberk, Mario H. H. Altieri, Hongqun Liu, Satish R. R. Raj, Samuel S. S. Lee
Summary: This article provides a comprehensive overview of the diagnosis, pathophysiology, and management of atrial fibrillation (AF) in patients with cirrhosis. It highlights the increased prevalence of AF in cirrhosis patients and the associated adverse outcomes, emphasizing the need for careful consideration of treatment options.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Taiki Sato, Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Hiroya Mizuno, Katsuki Okada, Tomoharu Dohi, Tetsuhisa Kitamura, Akihiro Sunaga, Hirota Kida, Bolrathanak Oeun, Yoshio Furukawa, Akio Hirata, Yasuyuki Egami, Tetsuya Watanabe, Hitoshi Minamiguchi, Miwa Miyoshi, Nobuaki Tanaka, Takafumi Oka, Masato Okada, Takashi Kanda, Yasuhiro Matsuda, Masato Kawasaki, Masaharu Masuda, Koichi Inoue, Yasushi Sakata
Summary: This study found that the extensive ablation strategy was superior to the PVI-alone strategy in both men and women with persistent AF, with no significant difference in efficacy between the sexes.
CIRCULATION JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Cardiac & Cardiovascular Systems
Flemming Javier Olsen, Caroline Lokke Bjerregaard, Kristoffer Grundtvig Skaarup, Mats Christian Hojbjerg Lassen, Niklas Dyrby Johansen, Daniel Modin, Gorm Boje Jensen, Peter Schnohr, Peter Sogaard, Gunnar Gislason, Jesper Hastrup Svendsen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Different event timing modalities have an impact on myocardial work indices, with visual assessment yielding lower global work index (GWI) values compared with Doppler-based methods.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Linz, Eva M. Hesselkilde, Mark A. Skarsfeldt, Julie N. Hertel, Stefan M. Sattler, Yannan Yan, Jacob Tfelt-Hansen, Jonas G. Diness, Bo H. Bentzen, Dominik Linz, Thomas Jespersen
Summary: Inhibition of small-conductance calcium-activated potassium channels (SK-channels) can prevent atrial fibrillation (AF) induced by obstructive sleep apnea (OSA) in a pig model without impairing ventricular electrophysiology.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sabbir A. Khan, Sara Marti-Sanchez, Dags Olsteins, Charalampos Lampadaris, Damon James Carrad, Yu Liu, Judith Quinones, Maria Chiara Spadaro, Thomas Sand Jespersen, Peter Krogstrup, Jordi Arbiol
Summary: Hybrid semiconductor-superconductor nanowires are widely used for studying gate-tunable superconductivity and the emergence of topological behavior. The low dimensionality and crystal structure flexibility of these nanowires enable unique heterostructure growth and efficient material optimization, which are crucial for accurately constructing complex multicomponent quantum materials.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Cardiac & Cardiovascular Systems
Jordi Heijman, Xiaobo Zhou, Stefano Morotti, Cristina E. Molina, Issam H. Abu-Taha, Marcel Tekook, Thomas Jespersen, Yiqiao Zhang, Shokoufeh Dobrev, Hendrik Milting, Jan Gummert, Matthias Karck, Markus Kamler, Ali El-Armouche, Arnela Saljic, Eleonora Grandi, Stanley Nattel, Dobromir Dobrev
Summary: This study found that patients with atrial fibrillation (AF) have higher SK-channel current (I-SK) in their heart cells, and the antiarrhythmic drug apamin can significantly prolong the action potential of these cells. In addition, the study also found that the abundance of SK2 channel on the cell membrane is higher in AF patients. It was discovered that inhibiting the phosphatase-2A-dependent calmodulin-Thr80 dephosphorylation and promoting the trafficking and targeting of SK-channel subunits can enhance the function of SK channels.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mikkel Ravn Dyhr, Flemming Javier Olsen, Soren Lindberg, Daniel Modin, Thomas Fritz-Hansen, Sune Pedersen, Allan Iversen, Soren Galatius, Thomas Jespersen, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: Measures of left atrial function can be used to predict atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG). In patients with a normal left atrial size, both the left atrial minimum volume index and the left atrial emptying fraction are significant predictors of AF.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Markus Hodal Drag, Karina Poulsdottir Debes, Clara Sandkamm Franck, Mette Flethoj, Mille Kronborg Lyhne, Jacob Eifer Moller, Trine Pagh Ludvigsen, Thomas Jespersen, Lisbeth Hoier Olsen, Tuomas O. Kilpelainen
Summary: Profiling cfDNA using nanopore sequencing and tissue-specific base modifications enables the monitoring of ongoing pathophysiological processes. This study identified differentially methylated regions (DMRs) associated with obesity in Gottingen minipigs using nanopore sequencing, validated a subset of DMRs using MSP-PCR, and compared cfDNA DMRs with gDNA DMRs. The results showed 1,236 cfDNA DMRs associated with obesity, with enrichment of pathways related to adipocytokine signaling and glucose homeostasis. No DMRs intersected between cfDNA and gDNA, suggesting that cfDNA originates from body-wide shedding of DNA.
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Morten S. Olesen, Jonas Bille Nielsen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to characterize the onset and progression of subclinical atrial fibrillation (AF) by analyzing 12-lead electrocardiogram (ECG) parameters. The results showed that P-wave duration (PWD) and interatrial block (IAB) were strongly associated with the onset, burden, and progression of AF.
Letter
Cardiac & Cardiovascular Systems
Oliver Bundgaard Vad, Christian Paludan-Muller, Laia Meseguer Monfort, Gustav Ahlberg, Jesper Hastrup Svendsen, Morten Salling Olesen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Christian Zinck Jensen, Jonas Lynggaard Isaksen, Gustav Ahlberg, Morten Salling Olesen, Birte Nygaard, Christina Ellervik, Jorgen Kim Kanters
Summary: This study found that single-nucleotide variations in certain genes are not associated with psychological well-being, cognitive function, or cardiovascular risk factors in patients receiving levothyroxine treatment. The results do not support a gene-treatment interaction in this context.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Pharmacology & Pharmacy
K. Hinz, M. K. Lyhne, K. P. Debes, M. J. Reimann, M. Flethoj, C. S. Bruun, T. P. Ludvigsen, J. Kirchhoff, T. Jespersen, H. D. Pedersen, J. E. Moller, L. H. Olsen
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)