Journal
VETERINARY CLINICAL PATHOLOGY
Volume 42, Issue 4, Pages 508-515Publisher
WILEY
DOI: 10.1111/vcp.12081
Keywords
Hemoconcentration; herbicide monitoring; triazine; water pollution
Categories
Funding
- center CENAQUA [CZ.1.05/2.1.00/01.0024, USB (GAJU), 087/2013/Z, CZ.1.07/2.3.00/20.0024]
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Background: Effects of acute and subchronic exposure of fish to s-triazine herbicides have been well documented, but data on the effects of prometryn on blood analytes in carp at environmentally realistic concentrations are lacking. Objective: The objective of the study was to determine whether biometrics, blood analytes, and histopathology could serve as bioindicators in fish living in waters polluted by triazine. Methods: Fish were exposed to prometryn at concentrations of 0.51 (reported concentration in Czech rivers), 8.0, and 80 mu g/L for 14, 30, and 60 days. Prior to and during this period, biometrics, blood analytes, and histopathology were evaluated. Results: After 60 days' exposure to 8.0 and 80 mu g/L of prometryn, spleen weights (P < .05) and lactate (P < .01) levels were significantly lower, and concentrations of HGB (P < .01) and MHC (P < .01) and MCHC (P < .01) were higher, relative to controls. After 30 and 60 days' exposure to 0.51, 8.0, and 80 mu g/L of prometryn, AST activity, calcium, magnesium, and inorganic phosphate levels were lower (P < .01), while creatinine concentration and ALT activity were higher (P < .01) than in controls. Glucose was higher after exposure to 80 mu g/L after 30 and 60 days, and after 60 days' exposure to 8.0 mu g/L. Renal histology revealed severe hyaline degeneration of the epithelial cells of caudal kidney tubules in fish at all exposure levels. Conclusions: This study shows effects in fish blood at a concentration of 0.51 mu g/L of prometryn, a significant finding in view of prometryn reaching a maximum of 4.4 mu g/L or less in European rivers. Select blood analytes, such as creatinine, and histologic changes in caudal kidney are potential biomarkers for monitoring residual triazine pesticides in Common Carp.
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