Article
Veterinary Sciences
T. Liatis, F. Theochari, L. Kalogianni, N. Soubasis, I. L. Oikonomidis, A. Velegraki, D. Psalla, E. Triantafyllou, M. Patsikas, Z. Polizopoulou
Summary: In this case study, a 13-year-old domestic cat presented with chronic progressive vestibular ataxia, lethargy, and anorexia, and was found to have fungal infection in the cerebrospinal fluid. Despite treatment, the cat deteriorated rapidly and was euthanased. Necropsy revealed inflammation in the brainstem, with PCR confirming Curvularia spp. infection.
AUSTRALIAN VETERINARY JOURNAL
(2021)
Review
Veterinary Sciences
Michaela J. Beasley, Andy Shores
Summary: This article discusses the many non-infectious inflammatory diseases that affect the nervous system in canine patients, which are assumed to be immune-mediated. It focuses on the treatment medications for meningoencephalomyelitis of unknown origin, including their adverse effects, therapeutic monitoring, and effectiveness. The use of a steroid/ Cytosar((R)) or steroid/ cyclosporine treatment protocol is strongly supported by the literature, with the steroid tapered after the acute phase of the disease. The decision on tapering the steroid is dependent on the clinician, as best practices have not been established.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Jasmin Nicole Nessler, Anna Oevermann, Marina Schawacht, Ingo Gerhauser, Ingo Spitzbarth, Sophie Bittermann, Frank Steffen, Martin Juergen Schmidt, Andrea Tipold
Summary: Meningoencephalitis of unknown origin (MUO) is a group of encephalitides in dogs where no infectious agent can be identified. This study finds that the boundaries between necrotizing and granulomatous variants of MUO may be smooth, blurring the distinction between necrotizing leukoencephalitis (NLE), necrotizing meningoencephalitis (NME), and granulomatous meningoencephalitis (GME).
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hyo Won Ahn, Zelia F. Worman, Arianna Lechsinska, Lindsay M. Payer, Tongguang Wang, Nasir Malik, Wenxue Li, Kathleen H. Burns, Avindra Nath, Henry L. Levin
Summary: Transposable elements (TEs) may contribute to the risk of neuropsychiatric diseases by affecting gene expression and regulation.
Review
Medicine, Research & Experimental
Nicholas E. Propson, Manasee Gedam, Hui Zheng
Summary: The classic innate immune signaling pathways play a crucial role in the immune response in the brain, despite their relative absence in this immune-privileged tissue. Studies over the past decade have linked complement protein production and activation to age-related functional changes and neurodegeneration. Reactivation of the complement signaling pathway in aging and disease has provided new insights into brain aging and neurological disease pathogenesis.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Nutrition & Dietetics
Mingke Guo, Xuan Wang, Yujuan Li, Ailin Luo, Yilin Zhao, Xiaoxiao Luo, Shiyong Li
Summary: As the global population ages, the prevalence of neurodegenerative diseases is increasing. Diet plays a crucial role in the development and progression of these diseases. Intermittent fasting (IF) has shown potential in improving neurological functions and reducing pathological injuries, with the gut microbiota and their metabolites believed to be central in mediating these effects.
Article
Public, Environmental & Occupational Health
Johnnie Yates, Todd Devere, Sharin Sakurai-Burton, Brock Santi, Cali McAllister, Kiana Frank
Summary: This article reports a case of a woman with PCR positive A. cantonensis infection who presented with symptoms of small fiber neuropathy but no headache. After undergoing a series of treatments, the patient's symptoms improved significantly, but she still required medication for one year to treat chronic neuropathy.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Clinical Neurology
Olukemi Adekanmbi, Olayinka Ilesanmi, Sulaiman Lakoh
Summary: Ebolavirus disease is a severe and often fatal systemic disease in human and non-human primates, with zoonotic and human-to-human transmission well documented. Neurologic manifestations in patients can range from mild confusion to severe conditions like meningitis and encephalitis. Rare neuropsychiatric symptoms in EVD include cognitive impairments like short-term memory loss and psychological symptoms like insomnia and depression. Despite the detection of Ebolavirus RNA in cerebrospinal fluid, further studies are needed to fully understand the pathogenic mechanisms of neurological disease in Ebolavirus infection.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Immunology
Sara Locke, Jane O'Bryan, Adeel S. Zubair, Melissa Rethana, Anne Spichler Moffarah, Peter J. Krause, Shelli F. Farhadian
Summary: This study aimed to investigate the neurologic complications of babesiosis in hospitalized patients and identify associated risk factors. More than half of the patients experienced neurologic symptoms, with headache, confusion/delirium, and impaired consciousness being the most frequent. These symptoms were associated with high-grade parasitemia, renal failure, and a history of diabetes mellitus. Clinicians in endemic areas should be aware of the range of symptoms, including neurologic, associated with babesiosis.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Virology
Moeinadin Safavi, Salameh Taghipour, Mohammad Vasei, Hamid Eshaghi, Mohammad Taghi Haghi Ashtiani
Summary: The study investigated the prevalence of bocaviruses and other viruses in children suspected of viral meningoencephalitis, with bocavirus not being detected in any of the CSF samples. The underlying cause of the disease remained unidentified in majority of cases, highlighting the need for further research to draw more accurate conclusions.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Ian Hewson, Isabella T. Ritchie, James S. Evans, Ashley Altera, Donald Behringer, Erin Bowman, Marilyn Brandt, Kayla A. Budd, Ruleo A. Camacho, Tomas O. Cornwell, Peter D. Countway, Aldo Croquer, Gabriel A. Delgado, Christopher DeRito, Elizabeth Duermit-Moreau, Ruth Francis-Floyd, Samuel Gittens, Leslie Henderson, Alwin Hylkema, Christina A. Kellogg, Yasunari Kiryu, Kimani A. Kitson-Walters, Patricia Kramer, Judith C. Lang, Harilaos Lessios, Lauren Liddy, David Marancik, Stephen Nimrod, Joshua T. Patterson, Marit Pistor, Isabel C. Romero, Rita Sellares-Blasco, Moriah L. B. Sevier, William C. Sharp, Matthew Souza, Andreina Valdez-Trinidad, Marijn van der Laan, Brayan Vilanova-Cuevas, Maria Villalpando, Sarah D. Von Hoene, Matthew Warham, Tom Wijers, Stacey M. Williams, Thierry M. Work, Roy P. Yanong, Someira Zambrano, Alizee Zimmermann, Mya Breitbart
Summary: Echinoderm mass mortality events have significant impacts on marine ecosystems. A recent mass mortality event affecting the sea urchin Diadema antillarum was investigated using molecular biology and veterinary pathology approaches. The presence of a scuticociliate most similar to Philaster apodigitiformis was consistently associated with abnormal urchins at affected sites, fulfilling Koch's postulates and indicating a new condition termed D. antillarum scuticociliatosis.
Article
Medicine, General & Internal
Clara Silva, Diana Ferrao, Mariana Almeida, Luis Nogueira-Silva, Jorge S. Almeida
Summary: In this case, a patient with corticosteroid-resistant ITP developed listeriosis, a dangerous opportunistic infection. Fortunately, early detection and treatment resulted in a favorable outcome for the patient.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Clinical Neurology
Gloria Mak, Suresh Menon, Jian-Qiang Lu
Summary: Neurofilaments are promising biomarkers for the diagnosis, monitoring, and prognosis of neurologic diseases, providing valuable insights into disease activity and long-term outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Infectious Diseases
Susanne Dyckhoff-Shen, Jan P. Bewersdorf, Nina C. Teske, Stefanie Voelk, Hans-Walter Pfister, Uwe Koedel, Matthias Klein
Summary: This study aimed to classify patients with cerebrospinal fluid pleocytosis to differentiate bacterial meningitis (BM) from other causes. The study found that patients with BM had higher cerebrospinal fluid cell count, and the CHANCE score could effectively predict BM.
Article
Microbiology
Hazel N. Farthing, Jiamei Jiang, Alexandra J. Henwood, Andy Fenton, Trent W. J. Garner, David R. Daversa, Matthew C. Fisher, David J. S. Montagnes
Summary: The study shows that free-living eukaryotic microbes may reduce animal diseases by controlling pathogens. Among them, the ciliate Tetrahymena pyriformis was found to grow at near its maximum rate and consume the pathogen at the highest ingestion rate.
FRONTIERS IN MICROBIOLOGY
(2021)