Article
Veterinary Sciences
Taisuke Nakagawa, Mari Kojima, Koichi Ohno, James K. Chambers, Kazuyuki Uchida, Aki Ohmi, Yuko Goto-Koshino, Hirotaka Tomiyasu, Hajime Tsujimoto
Summary: The study showed that continuous l-asparaginase administration is an effective and safe treatment option for dogs with large cell lymphoma of presumed GI origin. Most cases showed improvement in clinical signs at diagnosis, with a good treatment response.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Makoto Akiyoshi, Masami Akiyoshi
Summary: A 7-year-old spayed female Scottish Fold cat presented with jejunal LGL lymphoma, which was effectively treated with surgery and chemotherapy, leading to disease control and no recurrence.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Pathology
Nelly O. Elshafie, Naila C. do Nascimento, Nathanael I. Lichti, Andrea L. Kasinski, Michael O. Childress, Andrea P. dos Santos
Summary: Lymphoma is a common cancer in dogs, with DLBCL being the predominant type. By studying miRNA signatures, this research aimed to develop molecular diagnostic tools for DLBCL. The results showed downregulation of let-7 family and miR-155, as well as upregulation of miR-34a in DLBCL, with a combination of miR-34a and let-7f achieving 100% differentiation between DLBCL and controls.
VETERINARY PATHOLOGY
(2021)
Article
Veterinary Sciences
Jeong Mi Kim, Hong Jae Yi, Kun Ho Song, Kyoung Won Seo
Summary: This study focuses on three cases of dogs developing secondary lymphoma after chemotherapy, highlighting the importance of long-term follow-up for animals undergoing chemotherapy.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Veterinary Sciences
Richard Sheng, Dawn Clarke, Travis Laver, Kristina Meichner, Nicole Northrup, Jaime Tarigo
Summary: High CD25 expression in canine B-cell lymphoma may be associated with decreased risk of death, but not with survival time and progression. Further evaluation is needed.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Medicine, General & Internal
F. L. Locke, D. B. Miklos, C. A. Jacobson, M-A Perales, M-J Kersten, O. O. Oluwole, A. Ghobadi, A. P. Rapoport, J. McGuirk, J. M. Pagel, J. Munoz, U. Farooq, T. van Meerten, P. M. Reagan, A. Sureda, I. W. Flinn, P. Vandenberghe, K. W. Song, M. Dickinson, M. C. Minnema, P. A. Riedell, L. A. Leslie, S. Chaganti, Y. Yang, S. Filosto, J. Shah, M. Schupp, C. To, P. Cheng, L. Gordon, J. R. Westin
Summary: This international phase 3 trial showed that axicabtagene ciloleucel therapy significantly improved event-free survival and response in patients with early relapsed or refractory large B-cell lymphoma compared to standard care, despite the expected high-grade toxic effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Thomas M. Habermann
Summary: Several important updates have emerged in the management of early-stage diffuse large B-cell lymphoma, including the approval of the R-CHOP regimen for international use and studies on the optimal number of treatment cycles without radiation therapy. Tailored treatment strategies are recommended for patients with extranodal diseases, with molecular subtype evaluations potentially changing treatment approaches.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Veterinary Sciences
Celine A. Bik, Bart R. Ruijter, Lindsay van den Bossche, Erik Teske, Stijn J. M. Niessen, Yaiza Forcada
Summary: The study aimed to investigate pegylated-l-asparaginase monotherapy as a potential alternative treatment for feline large cell lymphoma. The response rate was found to be limited, but some cats showed a long disease-free period.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2023)
Article
Oncology
Colton Ladbury, Swetha Kambhampati, Tamer Othman, Claire Hao, Lu Chen, Jeffrey Wong, Thai Cao, Alex Herrera, Matthew Mei, Savita Dandapani
Summary: Approximately 50% of patients with relapsed/refractory diffuse large B cell lymphoma (R/R DLBCL) will relapse post-autologous stem cell transplant (ASCT). This study investigated the use of radiation therapy (RT) as salvage treatment for these patients. The results showed favorable oncologic outcomes for patients who received RT as first salvage therapy post-ASCT, particularly those with localized disease.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Multidisciplinary Sciences
Gi-June Min, Young-Woo Jeon, Tong Yoon Kim, Daehun Kwag, Byung-Su Kim, Joonyeop Lee, Jong Hyuk Lee, Sung-Soo Park, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Jong Wook Lee, Seok-Goo Cho
Summary: In this study, we analyzed the clinical characteristics and outcomes of 52 patients with relapsed/refractory diffuse large B cell lymphoma treated with allo-HSCT. Overall survival, event-free survival, and graft-versus-host disease-free, relapse-free survival outcomes were significantly better in patients who achieved remission before allo-HSCT. A shorter interval from diagnosis to allo-HSCT was associated with poorer survival and higher relapse rates. Patients with active disease had lower event-free survival and graft-versus-host disease-free, relapse-free survival.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Annalisa Arcari, Federica Cavallo, Benedetta Puccini, Daniele Vallisa
Summary: Most patients with Diffuse Large B-cell Lymphoma (DLBCL) are old (>65 years of age) and a simplified geriatric assessment is essential to choose the correct treatment intensity. Fit older patients can benefit from standard immunochemotherapy, while unfit/frail patients may require reduced doses or less toxic agents.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jin Hayakawa, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe
Summary: This study demonstrated that applying SHAP to a deep learning model using graph convolutions can provide pathway-level feature importance for classification prediction of gene expression subtypes in DLBCL.
Article
Oncology
Laura K. Hilton, Henry S. Ngu, Brett Collinge, Kostiantyn Dreval, Susana Ben-Neriah, Christopher K. Rushton, Jasper C. H. Wong, Manuela Cruz, Andrew Roth, Merrill Boyle, Barbara Meissner, Graham W. Slack, Pedro Farinha, Jeffrey W. Craig, Alina S. Gerrie, Ciara L. Freeman, Diego Villa, Judith A. Rodrigo, Kevin Song, Michael Crump, Lois Shepherd, Annette E. Hay, John Kuruvilla, Kerry J. Savage, Robert Kridel, Aly Karsan, Marco A. Marra, Laurie H. Sehn, Christian Steidl, Ryan D. Morin, David W. Scott
Summary: Diffuse large B-cell lymphoma (DLBCL) patients with early disease progression or relapse have poor outcomes. This study found that patients with late relapse had better outcomes after second-line therapy and autologous stem-cell transplantation compared to those with primary refractory or early relapse. Despite concordance in cell-of-origin classification and genetics-based subgroup between diagnostic and relapse biopsies, late relapses showed significant genetic differences and demonstrated branching evolution patterns. In highly divergent tumors, the same genes acquired new mutations independently, suggesting that shared precursor cells constrain tumor evolution towards the same genetics-based subgroups at both diagnosis and relapse.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Herve Tilly, Franck Morschhauser, Laurie H. Sehn, Jonathan W. Friedberg, M. Trneny, Jeff P. Sharman, Charles Herbaux, John M. Burke, Matthew Matasar, Shinya Rai, Koji Izutsu, Neha Mehta-Shah, Lucie Oberic, Adrien Chauchet, Wojciech Jurczak, Yuqin Song, Richard Greil, Larysa Mykhalska, Juan M. Bergua-Burgues, Matthew C. Cheung, Antonio Pinto, Ho-Jin Shin, Greg Hapgood, Eduardo Munhoz, Pau Abrisqueta, Jyh-Pyng Gau, Jamie Hirata, Yanwen Jiang, Mark Yan, Calvin Lee, Christopher R. Flowers, Gilles Salles
Summary: In untreated intermediate-risk or high-risk DLBCL patients, those who received pola-R-CHP had a lower risk of disease progression, relapse, or death compared to those who received R-CHOP. Overall survival and safety profiles were similar between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pathology
Kelly L. Hughes, E. J. Ehrhart, Emily D. Rout, Lauren J. Harris, Monica Fernandez, Janna A. Yoshimoto, Jeremy Dossey, Alana R. Kuzmik, Paul R. Avery, Anne C. Avery
Summary: The most common subtype of lymphoma in dogs is diffuse large B-cell lymphoma (DLBCL), while other forms of B-cell lymphoma in dogs are categorized as small-to-intermediate in size. Histologically, marginal zone lymphoma and follicular lymphoma have unique features, but the diffuse form of small B-cell lymphoma in dogs is poorly described. Current classification of small B-cell lymphoma relies on histopathology, although further characterization through gene expression profiling and other molecular tools is needed.
VETERINARY PATHOLOGY
(2021)