Article
Immunology
James G. Shepherd, Andrew E. Blunsum, Stephen Carmichael, Katherine Smollett, Hector Maxwell-Scott, Eoghan C. W. Farmer, Jane Osborne, Alasdair MacLean, Shirin Ashraf, Rajiv Shah, Rory Gunson, Ana da Silva Filipe, Emma J. Aarons, Emma C. Thomson
Summary: A case of hemorrhagic fever with renal syndrome caused by Seoul virus in a woman in Scotland was described, with whole-genome sequencing showing the virus belonged to a lineage characterized by recent international expansion likely driven by trade in pet rats.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Devinda S. Muthusinghe, Kenta Shimizu, Sithumini M. W. Lokupathirage, Zhouoxing Wei, Yomani D. Sarathkumara, G. R. Amanda Fonseka, Pavani Senarathne, Nobuo Koizumi, Tomonori Kawakami, Akio Koizumi, Chaminda Wickramasinghe, Hideki Ebihara, Keita Matsuno, Yoshimi Tsuda, Jiro Arikawa, Chandika D. Gamage, Kumiko Yoshimatsu
Summary: Genetic evidence from small mammals in a CKDu hotspot area of Sri Lanka revealed the presence of two THAIV-related hantaviruses, carried by rodents and Mus animals, suggesting a potential role in the induction of CKDu.
Article
Virology
Ana Claudia Pereira Tercas-Trettel, Alba Valeria Gomes de Melo, Renata Carvalho de Oliveira, Alexandro Guterres, Jorlan Fernandes, Liana Stretch Pereira, Marina Atanaka, Mariano Martinez Espinosa, Bernardo Rodrigues Teixeira, Cibele Rodrigues Bonvicino, Paulo Sergio D'Andrea, Elba Regina Sampaio de Lemos
Summary: This study investigated the seroprevalence of orthohantavirus infections in the Utiariti Indigenous land in the Brazilian Amazon, revealing prevalence rates of 12.4% in 2014 and 13.4% in 2015. Analysis of paired samples from 110 Indigenous individuals who participated in both study stages identified four individuals who seroconverted during the study period.
Letter
Immunology
Tais M. Wilson, Christopher D. Paddock, Sarah Reagan-Steiner, Julu Bhatnagar, Roosecelis B. Martines, Andrea L. Wiens, Michael Madsen, Kenneth K. Komatsu, Heather Venkat, Sherif R. Zaki
Summary: SARS-CoV-2 shares similar clinicopathologic features with other severe pulmonary illnesses. Differential diagnoses and possible co-infections should be considered in cases of respiratory distress during the SARS-CoV-2 pandemic.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Kaye Quizon, Kimberly Holloway, Mahmood Iranpour, Bryce M. Warner, Yvon Deschambault, Geoff Soule, Kevin Tierney, Darwyn Kobasa, Angela Sloan, David Safronetz
Summary: We demonstrate that six distinct Peromyscus rodent species can be experimentally infected with Sin Nombre orthohantavirus (SNV). Viral RNA and SNV antibodies were found in members of all six species. P. leucopus mice showed significantly higher viral and antibody titers compared to P. maniculatus mice, which are the established primary hosts for SNV.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Grant C. Paulsen, Robert Frenck Jr, Kay M. Tomashek, Rodolfo M. Alarcon, Elizabeth Hensel, Ashley Lowe, Rebecca L. Brocato, Steve A. Kwilas, Matthew D. Josleyn, Jay W. Hooper
Summary: This study evaluated the safety and immunogenicity of an ANDV DNA vaccine, which showed that the vaccine was safe and induced a robust and durable immune response.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Rene Lopez, Rodrigo Perez-Araos, Alvaro Salazar, Mauricio Espinoza, Cecilia Vial, Analia Cuiza, Pablo A. Vial, Jeronimo Graf
Summary: HVHF may contribute to supporting severe HCPS patients and avoiding the need for VA ECMO in some cases. Early connection to HVHF and a targeted strategy may increase the chance of success in these patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Renata Malachini Maia, Jorlan Fernandes, Luciana Helena Bassan Vicente de Mattos, Luiz Antonio Bastos Camacho, Karlla Antonieta Amorim Caetano, Megmar Aparecida dos Santos Carneiro, Fernando de Oliveira Santos, Sheila Araujo Teles, Elba Regina Sampaio de Lemos, Renata Carvalho de Oliveira
Summary: This study investigated the epidemiological aspects of HPS and the prevalence of hantavirus infection in sugarcane cutters in the Brazilian Midwest region. The results highlight the vulnerability of sugarcane cutters to this highly lethal disease.
Article
Public, Environmental & Occupational Health
Rui Wang, Xiang -yang Zhao, Xiao-jun Liu, Miao Zhang, Yan-ting Sun, Xiao Ning, Jian Xu, Chan-yuan Bu
Summary: This report describes a case of HFRS in a 55-year-old male patient who presented with fever, vomiting, and diarrhea. The patient developed multiple organ failure and was diagnosed with HFRS based on positive serum IgM antibodies. After antiviral therapy and supportive treatment, the patient showed improvement and was discharged.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Virology
Blas Armien, Carlos Munoz, Hector Cedeno, Jacqueline R. Salazar, Tybbyssay P. Salinas, Publio Gonzalez, Jose Trujillo, Deyanira Sanchez, Jamileth Marinas, Ayvar Hernandez, Harmodio Cruz, Leisy Yovany Villarreal, Elba Grimaldo, Samuel Gonzalez, Heydy Nunez, Susana Hesse, Fernando Rivera, George Edwards, Ricardo Chong, Ovidio Mendoza, Martin Meza, Milagro Herrera, Rudick Kant, Raul Esquivel, Dora Estripeaut, Demetrio Serracin, Bernardino Denis, Esthefani Robles, Yaxelis Mendoza, Gloria Gonzalez, Felicia Tulloch, Juan Miguel Pascale, Jonathan L. Dunnum, Joseph A. Cook, Anibal G. Armien, Fernando Gracia, Gladys Alicia Guerrero, Itza de Mosca
Summary: This article provides an overview of the epidemiological surveillance of hantavirus disease in Panama from 1999 to 2019. It reveals that hantavirus disease is a low-frequency disease primarily affecting young people, with a relatively low case-fatality rate. The disease shows annual and interannual variations influenced by agricultural activities and is endemic in approximately 27% of Panama. The decentralization of laboratory testing and dissemination of evidence-based surveillance guidelines have improved diagnosis and management of the disease.
Article
Biology
Durdica Cekinovic Grbesa, Nino Zahirovic, Viktorija Flego, Marija Livajic, Mari Roncevic Filipovic, Samira Knezevic, Irena Slavuljica
Summary: This study retrospectively analyzed the epidemiology, clinical presentation, and outcome of hantavirus infections in the western part of Croatia. The findings revealed that there was an outbreak of hantavirus infections in the previously considered hantavirus-free Mediterranean coastal area. This indicates the spread of hantavirus infections in Croatia from the central low-lying parts of the country to the tourist-attractive western area adjacent to the Mediterranean coast.
Article
Infectious Diseases
Pembe Derin Oygar, Ayse Buyukcam, Zumrut Sahbudak Bal, Nazan Dalgic, Sefika Elmas Bozdemir, Adem Karbuz, Benhur Sirvan Cetin, Yalcin Kara, Ceren Cetin, Nevin Hatipoglu, Hatice Uygun, Fatma Deniz Aygun, Selda Hancerli Torun, Dicle Sener Okur, Dilek Yilmaz Ciftdogan, Tugce Tural Kara, Aysun Yahsi, Arife Ozer, Sevliya Ocal Demir, Gulsen Akkoc, Cansu Turan, Enes Sali, Semra Sen, Emine Hafize Erdeniz, Soner Sertan Kara, Melike Emiroglu, Tugba Erat, Hacer Akturk, Sibel Lacinel Gurlevik, Murat Sutcu, Zeynep Gokce Gayretli Aydin, Basak Yildiz Atikan, Edanur Yesil, Gizem Guner, Emel Celebi, Kadir Efe, Didem Kizmaz Isancli, Habibe Selver Durmus, Seher Tekeli, Ayse Karaaslan, Lida Bulbul, Habip Almis, Ozge Kaba, Yildiz Ekemen Keles, Bahadir Yazicioglu, Serife Bahtiyar Oguz, Husnu Fahri Ovali, Hazal Helin Dogan, Solmaz Celebi, Deniz Cakir, Burcugul Karasulu, Gulsum Alkan, Irem Yenidogan, Doruk Gul, Burcu Pariltan Kucukalioglu, Gulhadiye Avcu, Musa Gurel Kukul, Melis Bilen, Belma Yasar, Tugba Ustun, Omer Kilic, Yasemin Akin, Sinem Oral Cebeci, Ibrahim Hakan Bucak, Mehpare Sari Yanartas, Aslihan Sahin, Sertac Arslanoglu, Murat Elevli, Rabia Coban, Sadiye Kubra Tuter Oz, Halil Hatipoglu, Ilyas Tolga Erkum, Mehmet Turgut, Asuman Demirbuga, Taha Ozcelik, Diclehan Ciftci, Emine Ergul Sari, Gokhan Akkus, Sadik Sami Hatipoglu, Ener Cagri Dinleyici, Mustafa Hacimustafaoglu, Ferda Ozkinay, Zafer Kurugol, Ali Bulent Cengiz, Ayper Somer, Hasan Tezer, Ates Kara
Summary: The study found that the seropositivity prevalence of SARS-CoV-2 among healthcare personnel is 6.1%, with a higher rate among those who do not universally wear protective masks. Having a COVID-19-positive co-worker increases the likelihood of infection, and both the least and most experienced personnel are more likely to be infected.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Johann Vulin, Severine Murri, Sarah Madrieres, Maxime Galan, Caroline Tatard, Sylvain Piry, Gabriele Vaccari, Claudia D'Agostino, Nathalie Charbonnel, Guillaume Castel, Philippe Marianneau
Summary: The study describes the isolation of two strains of PUUMALA orthohantavirus from two distinct French geographical areas: Ardennes (endemic area) and Loiret (non-endemic area). By selecting wild bank voles, cultivating the strains efficiently in Vero E6 cells, and propagating them in immunologically neutral bank voles, the impact of isolation methods on viral diversity was better assessed through high-throughput and Sanger sequencing results.
Article
Microbiology
Ilona Rissanen, Stefanie A. Krumm, Robert Stass, Annalis Whitaker, James E. Voss, Emily A. Bruce, Sylvia Rothenberger, Stefan Kunz, Dennis R. Burton, Juha T. Huiskonen, Jason W. Botten, Thomas A. Bowden, Katie J. Doores
Summary: Research demonstrates that the Gn glycoprotein of HTNV can elicit a neutralizing antibody response in rabbits, leading to the isolation of neutralizing and non-neutralizing monoclonal antibodies. Molecular-level insights on how the Gn glycoprotein may be targeted by the antibody-mediated immune response are provided for the first time. These findings may inform rational vaccine design approaches focused on targeting the hantavirus glycoprotein envelope.
Article
Biology
Rongrong Liu, Ruixue Ma, Ziyu Liu, Haifeng Hu, Jiayi Shu, Peizhen Hu, Junjun Kang, Yusi Zhang, Mingwei Han, Xiaoxiao Zhang, Yiting Zheng, Qikang Ying, Shiyuan Hou, Wenqiu Wang, Fang Wang, Ning Cheng, Yan Zhuang, Jianqi Lian, Xia Jin, Xingan Wu
Summary: The study shows that Hantaan virus can infect CD8(+) T cells in HFRS patients and these cells can support the full viral replication cycle. There is an association between CD8(+) T cell infection and disease progression in HFRS patients.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Aliye Bastug, Ayse Basak Altas, Bahattin Taylan Koc, Fatma Bayrakdar, Gulay Korukluoglu, Hurrem Bodur, Tuba Cigdem Oguzoglu
Summary: This study investigated the molecular epidemiology of respiratory HAdVs in patients with respiratory symptoms in Turkey. The most prevalent genotype was HAdV-B3, and HAdV-F was detected in some patients despite its typical gastrointestinal tropism. HAdV-B7 was identified as a reemerging pathogen in this study, along with a cluster of HAdV-C strains showing a close relationship with HAdV-2/6 recombination.
Article
Infectious Diseases
Imran Hasanoglu, Gulay Korukluoglu, Dilek Asilturk, Yasemin Cosgun, Ayse Kaya Kalem, Ayse Basak Altas, Bircan Kayaaslan, Fatma Eser, Esra Akkan Kuzucu, Rahmet Guner
Summary: This study demonstrates that asymptomatic patients have higher SARSCoV-2 viral loads than symptomatic patients. Unlike in the few studies in the literature, a significant decrease in viral load of nasopharyngeal/oropharyngeal samples was observed with increasing disease severity. Factors associated with poor prognosis are found to be significantly correlated with low viral load.
Article
Immunology
Gulay Korukluoglu, Umit Ozdemirer, Fatma Bayrakdar, Zehra Unal, Yasemin Cosgun, Tunca Atak, Hulya Karademirtok, Isil Ata, Fatih Kara
Summary: This study examined national data of AFP surveillance and enteroviruses (EV) epidemiology in Turkey from 2000 to 2019, and found that the higher detection rate of non-polio enteroviruses (NPEV) in samples from AFP pre-diagnosed cases may be attributed to the high polio vaccination rates in Turkey between 2008 and 2019. The most frequently detected NPEV serotypes were Coxackie A24, B3, and Echo 30.
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2021)
Article
Clinical Neurology
Ali Bulent Cengiz, Ceren Gunbey, Mehmet Ceyhan, Gulay Korukluoglu, Sevgen Tanir Basaranoglu, Nesibe Gevher Eroglu Ertugrul, Yasemin Cosgun, Bahadir Konuskan, Yasemin Ozsurekci, Banu Anlar
Summary: Encephalitis is a serious neurological syndrome with challenging diagnosis and uncertain etiology in many pediatric cases. A study on acute encephalitis of nonbacterial origin investigated demographic, clinical, and outcome data, showing favorable outcomes in most patients but with around one-fifth experiencing neurological deficits.
Article
Biotechnology & Applied Microbiology
Yasemin Cosgun, Ayse Basak Altas, Esra Akkan Kuzucu, Rahmet Guner, Sebnem Erdinc, Fatma Eser, Esra Kaya Kilic, Gulay Korukluoglu
Summary: This study examined antibody levels in patients with SARS-CoV-2 infection, finding that in symptomatic patients, IgM and IgA tests were positive after 10 days post-infection, and IgG tests were positive after 20 days. The sensitivity and specificity of different commercial kits were evaluated, and the rapid antibody test used in the study showed high levels of sensitivity and specificity.
FOLIA MICROBIOLOGICA
(2021)
Article
Immunology
Harun Yildiz, Erbu Yarci, Sefika Elmas Bozdemir, Nesrin Ozdinc Kizilay, Senay Mengi, Naciye Beskardesler, Gulay Korukluoglu, Andreas Mueller, Soyhan Bagci
Summary: This case report highlights the potential neurological involvement of SARS-CoV-2 in newborn infants, as demonstrated by a case of neuroradiologic abnormality associated with COVID-19 in a newborn infant presenting with afebrile seizure.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Infectious Diseases
Ahmet Naci Emecen, Ecem Basoglu Sensoy, Edanur Sezgin, Buket Yildirim Ustuner, Salih Keskin, Neslisah Siyve, Saadet Goksu Celik, Gamze Bayrak, Nurcan Senturk Durukan, Ayse Coskun Beyan, Alp Ergor, Belgin Unal, Gul Ergor
Summary: This study evaluated surveillance of healthcare workers and estimated the serial interval and incubation period of COVID-19, finding that these parameters were shorter in healthcare workers compared to the general population. Rigorous contact tracing and isolation measures could have led to shorter serial intervals, suggesting the need for stricter control measures focused on transmission between healthcare workers in hospital settings.
INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Adem Karbuz, Gulsen Akkoc, Tugba Bedir Demirdag, Dilek Yilmaz Ciftdogan, Arife Ozer, Deniz Cakir, Selda Hancerli Torun, Eda Kepenekli, Tugba Erat, Nazan Dalgic, Sare Ilbay, Ayse Karaaslan, Emine H. Erdeniz, F. Deniz Aygun, S. Elmas Bozdemir, Nevin Hatipoglu, Melike Emiroglu, Zumrut Sahbudak Bal, Ergin Ciftci, Gulsum Iclal Bayhan, Zeynep Gokce Gayretli Aydin, Sevliya Ocal Demir, Omer Kilic, Mustafa Hacimustafaoglu, Dicle Sener Okur, Semra Sen, Aysun Yahsi, Hacer Akturk, Benhur Cetin, Murat Sutcu, Manolya Kara, Hatice Uygun, Tugce Tural Kara, Gulay Korukluoglu, Ozlem Akgun, Gulnihan ustundag, Mevsim Demir Mis, Enes Sali, Ozge Kaba, Nurhayat Yakut, Orhan Kilic, M. Kemal Kanik, Ceren Cetin, Adem Dursun, Muharrem Cicek, Esra Kockuzu, Esra Sevketoglu, Gulsum Alkan, Gizem Guner Ozenen, Erdal Ince, Zekiye Baydar, Ahmet Kagan Ozkaya, Husnu Fahri Ovali, Seher Tekeli, Solmaz Celebi, Birgul Cubukcu, Alkan Bal, Fidan Khalilova, Mehmet Kose, Halil Ugur Hatipoglu, Tahir Dalkiran, Mehmet Turgut, Ayse Basak Altas, Hatice Nilgun Selcuk Duru, Ahu Aksay, Sevcan Saglam, Mehpare Sari Yanartas, Zeynep Ergenc, Yasemin Akin, Yeter Duzenli Kar, Sabit Sahin, Sadiye Kubra Tuteroz, Nimet Melis Bilen, Halil Ozdemir, Mine Cidem Senoglu, Burcu Pariltan Kucukalioglu, Gulser Esen Besli, Yalcin Kara, Cansu Turan, Burcu Selbest Demirtas, Aydin Celikyurt, Yasemin Cosgun, Murat Elevli, Aslihan Sahin, Serife Bahtiyar Oguz, Ayper Somer, Bulent Karadag, Recep Demirhan, Hatice Turk Dagi, Zafer Kurugol, Esra Cakmak Taskin, Aysegul Sahiner, Edanur Yesil, Yildiz Ekemen Keles, Remzi Sarikaya, Ela Erdem Eralp, Ferda Ozkinay, Hatice Kubra Konca, Songul Yilmaz, Yasemin Gokdemir, Gul Arga, Seval Ozen, Fevziye Coksuer, Goksel Vatansever, Hasan Tezer, Ates Kara
Summary: This study aimed to identify the epidemiological, clinical, and laboratory features of pediatric COVID-19 cases in Turkey. A total of 1,156 confirmed cases were included in the study, with the most common symptoms being fever and cough. Children of all ages appear to be susceptible to COVID-19, with significant differences in symptomatology and laboratory findings by age group.
FRONTIERS IN PEDIATRICS
(2021)
Article
Allergy
Ismail Cem Yilmaz, Emre Mert Ipekoglu, Artun Bulbul, Nilsu Turay, Muzaffer Yildirim, Irem Evcili, Naz Surucu Yilmaz, Nese Guvencli, Yagmur Aydin, Bilgi Gungor, Berfu Saraydar, Asli Gulce Bartan, Bilgehan Ibibik, Tugce Bildik, Ilayda Baydemir, Hatice Asena Sanli, Basak Kayaoglu, Yasemin Ceylan, Tugce Yildirim, Irem Abras, Ihsan Cihan Ayanoglu, Sefa Burak Cam, Eda Ciftci Dede, Merve Gizer, Osman Erganis, Fahriye Sarac, Serdar Uzar, Hakan Enul, Cumhur Adiay, Gamze Aykut, Hivda Polat, Ismail Selim Yildirim, Saban Tekin, Gulay Korukluoglu, Hasan Ersin Zeytin, Petek Korkusuz, Ihsan Gursel, Mayda Gursel
Summary: The study demonstrates that VLP vaccines incorporating all four structural protein antigens of SARS-CoV-2 are immunogenic and can protect animals from developing COVID-19 infection.
Article
Immunology
Meliha Cagla Sonmezer, Enes Erul, Taha Koray Sahin, Ipek Rudvan Al, Yasemin Cosgun, Gulay Korukluoglu, Humeyra Zengin, Guelcin Telli Dizman, Ahmet Cagkan Inkaya, Serhat Unal
Summary: This large cross-sectional study from a tertiary care hospital in Turkey evaluated the seroprevalence rates in HCWs and found that frontline HCWs who had contact with patients and HCWs in COVID-19 units or intensive care units had higher levels of antibodies. HCWs caring for regular patients in the medium-risk group also had a higher risk of infection.
Article
Virology
Sedat Kaygusuz, Gulay Korukluoglu, Yasemin Cosgun, Omer Sahin, Ferhat Arslan
Summary: Understanding the immune responses to SARS-CoV-2 infection is crucial for public health policy, vaccine development, and prevention of reinfections. This study found a strong correlation between antibody levels and disease severity and demonstrated that the antibodies can persist and increase after vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ahmet Omma, Ayse Batirel, Mehtap Aydin, Fatma Yilmaz Karadag, Abdulsamet Erden, Orhan Kucuksahin, Berkan Armagan, Serdar Can Guven, Ozlem Karakas, Selim Gokdemir, Lutfiye Nilsun Altunal, Aslihan Ayse Buber, Emin Gemcioglu, Oguzhan Zengin, Osman Inan, Enes Seyda Sahiner, Gulay Korukluoglu, Zafer Sezer, Aykut Ozdarendeli, Ates Kara, Ihsan Ates
Summary: This study aimed to evaluate the safety and immunogenicity of CoronaVac and TURKOVAC vaccines used as a booster dose after CoronaVac primary vaccination. The results showed that neutralizing antibody titers decrease over time after two doses of CoronaVac vaccine. However, the booster dose of either CoronaVac or TURKOVAC rapidly increased neutralizing antibody titers, with similar effects against the Wuhan variant and more antibodies developed against the Delta variant with TURKOVAC.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
Yasemin Cosgun, Ahmet Aydemir, Hakan Hedef, Ayten Oz Kamiloglu, Oliver Klemens, Erik Lattwein, Julia Maria Klemens, Sandra Saschenbrecker, Katja Steinhagen, Gulay Korukluoglu
Summary: This study evaluated the performance of the new EUROIMMUN anti-CCHFV IgM and IgG enzyme-linked immunosorbent assays (ELISAs). The results showed that these ELISAs have high sensitivity and specificity, with strong concordance and correlation with other reference methods. Therefore, these new ELISAs can be used for reliable identification of acute CCHF cases in on-site outbreak support situations.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2023)
Article
Immunology
Yasemin Cosgun, Nergis Emanet, Ayten Oz Kamiloglu, Evelin Grage-Griebenow, Susann Hohensee, Sandra Saschenbrecker, Katja Steinhagen, Gulay Korukluoglu
Summary: This study analyzes the short-term humoral responses against the SARS-CoV-2 spike and nucleocapsid protein in 50 Turkish adults after CoronaVac immunization. The results showed that two doses of CoronaVac vaccine significantly increased antibodies against the spike protein and nucleocapsid. The responses to the spike protein were stronger than those to the nucleocapsid.
Article
Immunology
Ihsan Ates, Ayse Batirel, Mehtap Aydin, Fatma Yilmaz Karadag, Abdulsamet Erden, Orhan Kucuksahin, Berkan Armagan, Serdar Can Guven, Ozlem Karakas, Selim Gokdemir, Lutfiye Nilsun Altunal, Aslihan Ayse Buber, Emin Gemcioglu, Oguzhan Zengin, Osman Inan, Enes Seyda Sahiner, Gulay Korukluoglu, Zafer Sezer, Aykut Ozdarendeli, Ahmet Omma, Ates Kara
Summary: This study aimed to present the long-term immunogenicity results of the double-blind, randomized, controlled phase II Hybrid COV-RAPEL TR Study, in which TURKOVAC or CoronaVac vaccines were used as a booster after the second dose of primary vaccination with CoronaVac. The results showed that a single booster dose increased antibody positivity on Day 28, which persisted until Day 84 with a slight decrease. However, an additional booster dose may be required thereafter, as the antibody titer may decrease faster over time.
