Article
Biochemistry & Molecular Biology
Bilgehan Ozcan, Britanny Blachot-Minassian, Stephanie Paradis, Lucile Maziere, Marie Chambion-Diaz, Sophie Bouyon, Jean-Louis Pepin, Vincent Pialoux, Claire Arnaud, Christophe Moinard, Elise Belaidi
Summary: Intermittent hypoxia, a hallmark of obstructive sleep apnea, triggers oxidative stress and contributes to cardiovascular consequences. Citrulline supplementation has shown protective effects on the cardiovascular system. This study demonstrates that citrulline significantly reduces blood pressure and infarct size under intermittent hypoxia, indicating its potential as a pharmacological strategy for high-risk OSA patients.
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Xiao-Bin Zhang, Hui-Juan Cheng, Ya-Ting Yuan, Yan Chen, Yi-Yuan Chen, Kam Yu Chiu, Hui-Qing Zeng
Summary: This study assessed the effects of atorvastatin on chronic intermittent hypoxia-induced myocardial oxidative stress and apoptosis in a mouse model of obstructive sleep apnea. Atorvastatin reversed the reduction in antioxidant activity caused by CIH, but had no effect on myocardial apoptosis.
Article
Biochemistry & Molecular Biology
Shin Koike, Haruka Sudo, Satori Turudome, Masako Ueyama, Yoshiaki Tanaka, Hiroshi Kimura, Yo-Ichi Ishida, Yuki Ogasawara
Summary: This study analyzed Prx2-SO2/3 levels in clinical samples and found a positive correlation between the oxidation state of Prx2 in red blood cells and the severity of obstructive sleep apnea (OSA). Prx2-SO2/3 may serve as a promising biomarker for OSA.
Article
Biochemistry & Molecular Biology
Fatima O. Martins, Joana F. Sacramento, Elena Olea, Bernardete F. Melo, Jesus Prieto-Lloret, Ana Obeso, Asuncion Rocher, Paulo Matafome, Emilia C. Monteiro, Silvia Conde
Summary: Several studies have shown a connection between obstructive sleep apnea (OSA) and insulin resistance. This study investigated the effects of chronic intermittent hypoxia (CIH) on metabolic deregulation and adipose tissue dysfunction, as well as the impact of obesity on CIH-induced metabolic disturbances. The results suggest that adipose tissue dysfunction may not be the main trigger for initial dysmetabolism in CIH.
Article
Physiology
Jiexin Zhang, Songyuan Tang, Chao Chen, Hezhong Jiang, Hai Liao, Huawei Liu, Li Wang, Xin Chen
Summary: This study systematically analyzed and visualized research on sleep disturbances and cognitive impairment at high altitudes using bibliometrics method. The findings showed that more attention is being focused on these issues and the study serves as a useful reference for the clinical development of treatments.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
David C. Andrade, Camilo Toledo, Hugo S. Diaz, Katherin Pereyra, Karla G. Schwarz, Esteban Diaz-Jara, Claudia Melipillan, Angelica P. Rios-Gallardo, Atenea Uribe-Ojeda, Julio Alcayaga, Rodrigo A. Quintanilla, Rodrigo Iturriaga, Jean-Paul Richalet, Nicolas Voituron, Rodrigo Del Rio
Summary: The study demonstrated that cEpo treatment significantly reduced the carotid body chemoreflex and hypertension induced by CIH, and normalized breathing patterns. This suggests a potential therapeutic application of cEpo in treating cardiorespiratory disorders associated with CIH.
JOURNAL OF HYPERTENSION
(2021)
Article
Clinical Neurology
Xin Zhen, Esteban A. Moya, Mary Gautane, Huayi Zhao, Elijah S. Lawrence, Wanjun Gu, Laura A. Barnes, Jason X-J Yuan, Pritesh P. Jain, Mingmei Xiong, Pablo Catalan Serra, Luu Pham, Atul Malhotra, Tatum S. Simonson, Omar A. Mesarwi
Summary: This study found that overlap hypoxia (OH) may represent a unique and deleterious cardio-metabolic stimulus, causing systemic and pulmonary hypertension, and without protective metabolic effects characteristic of sustained hypoxia (SH).
Article
Biochemistry & Molecular Biology
Yang Ji, Yingmin Liang, Pak Hin Chu, Mengqin Ge, Sze Chun Yeung, Mary Sau Man Ip, Judith Choi Wo Mak
Summary: This study suggests that intermittent hypoxia (IH) may lead to liver injury by modulating hepatic CD36 expression in lean and diet-induced obese mice.
BIOMEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zhiyong Du, Haili Sun, Yunhui Du, Linyi Li, Qianwen Lv, Huahui Yu, Fan Li, Yu Wang, Xiaolu Jiao, Chaowei Hu, Yanwen Qin
Summary: Obstructive sleep apnea (OSA) can worsen blood pressure and increase the risk of cardiovascular disease in hypertensive individuals, yet the underlying pathophysiological process is still not completely understood. This study utilized metabolome and lipidome-wide analyses to identify metabolic abnormalities associated with OSA and developed a model for diagnosing OSA in hypertensive individuals.
Article
Biology
Liasmine Haine, Juliette Bravais, Celine-Hivda Yegen, Jean-Francois Bernaudin, Dominique Marchant, Carole Planes, Nicolas Voituron, Emilie Boncoeur
Summary: The study found that intermittent hypoxia exacerbates lung fibrosis, especially when exposure to hypoxia precedes the induction of lung fibrosis. The enhancement of ER stress markers may be involved in the underlying mechanisms.
Article
Oncology
Elena Diaz-Garcia, Sara Garcia-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarron, Begona Sanchez-Sanchez, Ana Sastre-Perona, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: The study shows that patients with obstructive sleep apnea (OSA) exhibit elevated levels of PSPC1, which is cleaved from monocytes by MMP2 and released into the plasma. Intermittent hypoxia (IH) promotes the expression of PSPC1, TGF beta, and MMP2 in monocytes, leading to increased expression of genes driving epithelial-to-mesenchymal transition. These findings suggest a mechanism by which hypoxemia contributes to tumor progression and aggressiveness in OSA patients.
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Federica Zoccali, Francesca Cascone, Vanessa Di Stefano, Antonio Greco, Marco de Vincentiis, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The associated oxidative stress (OS) leads to various complications that affect both sleep-wake rhythm and systemic functions. This literature review investigates the molecular changes, diagnostic markers, and potential medical therapies for OSAS. The findings suggest that IH increases oxygen free radicals (ROS) and impairs antioxidant capacities, resulting in endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations in OSAS patients. The most promising pharmacological therapies include N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but further research is needed. Continuous positive airway pressure (CPAP) remains the approved therapy for reversing most molecular changes, while future drugs may target the remaining dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Humberto Morales-Loredo, Adelaeda Barrera, Joshua M. Garcia, Carolyn E. Pace, Jay S. Naik, Laura Gonzalez Bosc, Nancy L. Kanagy
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jessica B. Snow, Charles E. Norton, Michelle A. Sands, Laura Weise-Cross, Simin Yan, Lindsay M. Herbert, Joshua R. Sheak, Laura Gonzalez Bosc, Benjimen R. Walker, Nancy L. Kanagy, Nikki L. Jernigan, Thomas C. Resta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Physiology
Joshua R. Sheak, David T. Jones, Benjamin J. Lantz, Levi D. Maston, Danielle Vigil, Thomas C. Resta, Micaela M. Resta, Tamara A. Howard, Nancy L. Kanagy, Yan Guo, Ewa Jankowska-Gan, Jeremy A. Sullivan, Rudolf K. Braun, William J. Burlingham, Laura V. Gonzalez Bosc
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Aleksandr Birg, Henry C. Lin, Nancy Kanagy
Summary: Hydrogen sulfide is an endogenous signaling molecule that modulates the vascular system by dilating mesenteric and portal vasculature. It is primarily produced and detoxified in the colon, and increases portal venous blood flow in a NO-dependent fashion.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Adelaeda Barrera, Humberto Morales-Loredo, Joshua M. Garcia, Gisel Fregoso, Carolyn E. Pace, Perenkita J. Mendiola, Jay S. Naik, Laura V. Gonzalez Bosc, Nancy L. Kanagy
Summary: In sleep apnea, airway obstruction can lead to intermittent hypoxia, which may impact hydrogen sulfide generation and regulation of blood pressure and vascular resistance. Experimental findings suggest that IH exposure could decrease CSE expression in larger resistance arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Camilla F. Wenceslau, Cameron G. McCarthy, Scott Earley, Sarah K. England, Jessica A. Filosa, Styliani Goulopoulou, David D. Gutterman, Brant E. Isakson, Nancy L. Kanagy, Luis A. Martinez-Lemus, Swapnil K. Sonkusare, Pratish Thakore, Aaron J. Trask, Stephanie W. Watts, R. Clinton Webb
Summary: The measurement of vascular function in isolated vessels provides important insights into the cardiovascular system's structure and pathological changes. It has led to the discovery of treatments for cardiovascular diseases and raised concerns about scientific rigor and reproducibility. Therefore, establishing guidelines for evaluating isolated vascular function is necessary to ensure consistent and reliable results.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Camilla F. Wenceslau, Cameron G. McCarthy, Scott Earley, Sarah K. England, Jessica A. Filosa, Styliani Goulopoulou, David D. Gutterman, Brant E. Isakson, Nancy L. Kanagy, Luis A. Martinez-Lemus, Swapnil K. Sonkusare, Pratish Thakore, Aaron J. Trask, Stephanie W. Watts, R. Clinton Webb
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Camilla F. Wenceslau, Cameron G. McCarthy, Scott Earley, Sarah K. England, Jessica A. Filosa, Styliani Goulopoulou, David D. Gutterman, Brant E. Isakson, Nancy L. Kanagy, Luis A. Martinez-Lemus, Swapnil K. Sonkusare, Pratish Thakore, Aaron J. Trask, Stephanie W. Watts, R. Clinton Webb
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Physiology
Selina M. Garcia, Benjamin Matheson, Juan H. Morales-Loredo, Nikki L. Jernigan, Nancy L. Kanagy, Thomas C. Resta, Ross M. Clark, Reza Shekarriz, Laura V. Gonzalez Bosc
Summary: This article discusses the symptoms and physiological responses to hypoxia, and proposes the hypothesis of hypoxia-induced biomarkers. The authors found that ET-1 levels return to normal after returning to normal oxygen levels, while the levels of miR-21 and H2S remain decreased.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Perenkita J. Mendiola, Emily E. Morin, Laura V. Gonzalez Bosc, Jay S. Naik, Nancy L. Kanagy
Summary: This study demonstrates that endothelial cell plasma membrane cholesterol limits H2S-induced vasodilation through effects on TRPV4 and BKCa channels.
Article
Chemistry, Analytical
B. T. Matheson, R. B. Osofsky, D. M. Friedrichsen, B. J. Brooks, R. M. Clark, N. L. Kanagy, R. Shekarriz
Summary: A novel non-invasive system has been developed to measure transdermally emitted hydrogen sulfide (H2S) from the upper and lower limbs of human subjects. The system's measurement precision is comparable to a commercially available device, and it has potential clinical applications.
SENSING AND BIO-SENSING RESEARCH
(2022)
Article
Cell Biology
Jacob R. Anderson, Emily E. Morin, Kathryn J. Brayer, Sophia Salbato, Laura V. Gonzalez Bosc, Nancy L. Kanagy, Jay S. Naik
Summary: The study investigated the differences in gene expression and metabolic pathways between endothelial cells and vascular smooth muscle cells in large and small arteries using single-cell RNA sequencing. The results revealed differentially expressed genes and pathways, leading to a better understanding of phenotypic heterogeneity in different types of blood vessels.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Surgery
Benjamin T. Matheson, Robin B. Osofsky, Debra M. Friedrichsen, Bill J. Brooks, Joseph Giacolone, Mehdy Khotan, Reza Shekarriz, Vernon Shane Pankratz, Eric J. Lew, Ross M. Clark, Nancy L. Kanagy
Summary: A novel transdermal arterial gasotransmitter sensor (TAGS) has been tested for diagnosing lower limb microvascular disease in individuals with and without diabetes. The TAGS system measures hydrogen sulfide emitted from the skin and has shown promising results in detecting early-stage peripheral artery disease (PAD) and diabetic ulcers.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2023)
Article
Physiology
Perenkita J. Mendiola, Jay S. Naik, Laura V. Gonzalez Bosc, Amy S. Gardiner, Aleksandr Birg, Nancy L. Kanagy
Summary: Hydrogen sulfide is a small, gaseous signaling molecule with poor solubility in water that is generated by multiple pathways in various species, including humans. It has both beneficial and pathological effects in tissues, and plays a role in regulating vascular tone, angiogenesis, endothelial barrier function, redox, and inflammation. It is also implicated in promoting tumor growth and contributing to the development of metabolic diseases in certain disease states.
COMPREHENSIVE PHYSIOLOGY
(2021)
Article
Physiology
Humberto Morales-Loredo, David Jones, Adelaeda Barrera, Perenkita J. Mendiola, Joshua Garcia, Carolyn Pace, Minerva Murphy, Nancy L. Kanagy, Laura V. Gonzalez Bosc
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)