Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Ashley E. Walker, Jazmin A. Cole, Sahana Krishna Kumaran, Jonathan I. Kato, Xinhao Zhuang, Julia R. Wolf, Grant D. Henson, Belinda H. McCully
Summary: Obesity increases the risk of complications and mortality after trauma, which are associated with vascular damage. The impact of obesity on vascular dysfunction after traumatic hemorrhage is unclear. This study suggests that obesity may potentiate trauma-induced vascular inflammation and dysfunction.
Article
Pharmacology & Pharmacy
Qi Yu, Kun Li, Andong Zhao, Mengqian Wei, Zhenhao Huang, Yunting Zhang, Ying Chen, Ting Lian, Chuan Wang, Li Xu, Yaping Zhang, Cangbao Xu, Fuqiang Liu
Summary: Sorafenib impairs endothelium-dependent vasodilation by reducing NO levels and expression of NO synthetases, while enhancing ETB receptor-mediated vasoconstriction, which may lead to hypertension and other adverse vascular effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Yoon Jung Choi, Adam M. Heck, Brian J. Hayes, Daniel Lih, Samuel G. Rayner, Brandon Hadland, Ying Zheng
Summary: The human fetal liver endothelium plays a unique role in supporting the maturation and expansion of multilineage hematopoietic stem and progenitor cells, with EC-derived WNT5A identified as a key factor in this process. The study highlights the significance of organ-specific endothelial niche in hematopoietic development and provides insights into potential signals for HSPC expansion in clinical applications.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Physiology
Janee D. Terwoord, Matthew L. Racine, Christopher M. Hearon, Gary J. Luckasen, Frank A. Dinenno
Summary: The study demonstrates that endothelium-dependent agonists interact to induce vasodilation and limit α-adrenergic vasoconstriction in humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oguzhan Yildiz, Kemal Gokhan Ulusoy
Summary: This review summarizes the role of taurine in vascular tone and blood pressure modulation. Taurine supplementation prevents hypertension and reduces blood pressure in hypertensive patients. The mechanisms underlying taurine's vascular effects are still largely unknown.
Article
Multidisciplinary Sciences
Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming, Caroline Manicam
Summary: The Cyp2c44-derived EETs in VSMC are shown to mediate vasoconstriction of the ophthalmic artery, as evidenced by experimental studies.
SCIENTIFIC REPORTS
(2021)
Review
Hematology
Jean-Baptiste Michel, Jeremy Lagrange, Veronique Regnault, Patrick Lacolley
Summary: The arterial wall is organized into layers, with each layer playing a specific role in clearing substances from the blood. The endothelium acts as a barrier, while the media layer is involved in taking up molecules and particles. The outer layers, including the adventitia and perivascular tissue, also contribute to the clearance functions. These clearance functions are essential for maintaining arterial health but can also contribute to pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Charles U. Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lenka Turner, Paulina J. Stanczyk, Sonja Khemiri, Julie C. Chamberlain, Wei Yang, Tom R. Webb, Christopher P. Nelson, Nilesh J. Samani, Shu Ye
Summary: This comprehensive analysis shows that a large percentage of CAD loci can modulate gene expression in VSMCs and influence VSMC behavior. Several candidate causal genes identified are likely to be druggable and thus represent potential therapeutic targets.
Review
Biochemistry & Molecular Biology
Claudia Rodriguez, Mercedes Munoz, Cristina Contreras, Dolores Prieto
Summary: AMPK serves as a crucial cellular energy sensor activated during energy stress, playing a key role in maintaining energy homeostasis. It is involved in various functions such as mitochondrial biogenesis, redox regulation, cell growth, autophagy, and inflammation. Recent studies have highlighted the protective role of AMPK in cardiovascular function and its association with cardiovascular disease pathogenesis.
Article
Microbiology
Koon-Chu Yaiw, Abdul-Aleem Mohammad, Chato Taher, Huanhuan Leah Cui, Helena Costa, Ourania N. Kostopoulou, Masany Jung, Alice Assinger, Vanessa Wilhelmi, Jiangning Yang, Klas Straat, Afsar Rahbar, John Pernow, Cecilia Soderberg-Naucler
Summary: The study found that HCMV infection significantly decreased ET-1 expression, promoted accumulation of ET-1 precursor protein in infected endothelial cells, and inhibited ET-1 maturation. Treatment with Ganciclovir did not prevent the suppressive effects of the virus on ET-1 expression. The IE2-p86 protein was identified to predominantly modulate ET-1 expression.
Review
Neurosciences
Osama F. Harraz, Lars Jorn Jensen
Summary: Changes in cellular Ca2+ levels due to vascular ageing can significantly impact vascular function, blood pressure regulation and cardiovascular diseases. Ageing may cause abnormal Ca2+ signalling in SMCs and ECs, leading to dysregulation of vascular tone and blood flow distribution, thereby increasing the risk of cardiovascular diseases. Research on specific ageing-related Ca2+ signalling deficits is crucial to combat accelerated vascular ageing and its associated health risks in an ageing population.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Fangfang Xu, Jinhang Zhu, Ye Chen, Ke He, Jizheng Guo, Suwen Bai, Ren Zhao, Juan Du, Bing Shen
Summary: The study demonstrated the mechanism of action of TPM3 and STIM1 in rat VSMCs, providing a potential therapeutic target for high-salt intake-induced hypertension.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Dariia O. Dryn, Mariia I. Melnyk, Donal Melanaphy, Igor V. Kizub, Christopher D. Johnson, Alexander V. Zholos
Summary: This study demonstrates for the first time the biphasic contractile reaction of TRPV4 in rat pulmonary artery, showing relaxation followed by a contraction. The relaxation phase is induced by BKCa activation, while the subsequent contraction is mediated by TRPV4-dependent depolarization and Ca-L activation. Similar changes in membrane potential are observed with the activation of TRPM8 in the rat tail artery.
Review
Pharmacology & Pharmacy
Lars Edvinsson, Jacob C. A. Edvinsson, Kristian A. Haanes
Summary: Migraine is a common neurological disorder affecting up to 15% of the global population. Recent pharmacological treatments targeting CGRP signaling molecules have provided safe and effective options for migraine patients, offering new hope for migraine therapy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Bentsen, Anette Sams, Philip Hasbak, Lars Edvinsson, Andreas Kjaer, Rasmus S. Ripa
Summary: The study found that the CGRP analogue, SAX, has a cardioprotective effect in a rat model of myocardial infarction, improving myocardial perfusion recovery after chronic occlusion of the coronary artery.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin Lyngby Lassen, Christina Byrne, Majid Sheykhzade, Mads Wissenberg, Preetee Kapisha Hurry, Anne Vibeke Schmedes, Andreas Kjaer, Philip Hasbak
Summary: After caffeine consumption, sex-specific differences in hemodynamic response were mainly observed in men. Caffeine consumption led to reduced stress MBF and MFR assessments in men, while no similar changes were reported in women.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Cardiac & Cardiovascular Systems
Martin Lyngby Lassen, Mads Wissenberg, Christina Byrne, Majid Sheykhzade, Preetee Kapisha Hurry, Anne Vibeke Schmedes, Andreas Kjaer, Philip Hasbak
Summary: This study aimed to investigate the potential of different markers to identify adequate stressing in subjects with or without caffeine intake. The results showed that various markers provided acceptable sensitivity and specificity when patients followed the caffeine pausation before myocardial perfusion imaging, but caution should be exercised when caffeine consumption cannot be ruled out.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Review
Cell Biology
Philip Victor Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: Migraines are a common neurological disorder characterized by inflammation and sensitization mechanisms, with intracranial meningeal inflammation playing a key role. Animal models have provided valuable insights into these mechanisms.
Article
Clinical Neurology
Aida Maddahi, Lars Edvinsson, Karin Warfvinge
Summary: The expression of vasopressin and its receptors in the brain and trigeminovascular system, particularly in migraine-related regions, was identified. No differences in CGRP and vasopressin expression were found between male and female rats in the trigeminal ganglion. However, the number of RAMP1, oxytocin, oxytocin receptor, and vasopressin receptors immunoreactive cells were higher in females. Vasopressin and its receptors were expressed in both hypothalamus and trigeminal ganglion, with higher levels of vasopressin mRNA in the hypothalamus. Vasopressin and closely related oxytocin may play important roles in migraine pathophysiology.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Chemistry, Medicinal
Jesper Peter Bomers, Anne-Sofie Grell, Lars Edvinsson, Sara Ellinor Johansson, Kristian Agmund Haanes
Summary: This study investigated the effects of trametinib treatment on female rats with induced subarachnoid haemorrhage. The results showed that trametinib treatment significantly improved arterial contractility, reduced subacute increases in intracranial pressure, and improved sensorimotor and neurological outcomes in female rats.
Article
Clinical Neurology
Philip V. Reducha, Jesper P. Boemers, Lars Edvinsson, Kristian A. Haanes
Summary: This study aimed to investigate the behavioral changes similar to migraine caused by CFA application on the skull in rats, and the potential mitigating effects of the CGRP specific antibody fremanezumab after CFA application. The results showed that surgical application of CFA to the dura caused periorbital allodynia and increased CGRP positive fibers in the trigeminal ganglion. However, fremanezumab did not alleviate periorbital allodynia, although it reduced the amount of CGRP positive fibers.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Kristian A. Haanes, Lars Edvinsson
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Lena Erlandsson, Lena Ohlsson, Zahra Masoumi, Mimmi Rehnstrom, Tina Cronqvist, Lars Edvinsson, Stefan R. Hansson
Summary: Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and organ damage. This study found that placenta-derived extracellular vesicles (STBEVs) in PE patients have negative effects on vascular contractility and cause structural damage to blood vessels. These effects can be reduced by blocking vesicle uptake. This discovery provides a new therapeutic strategy for preventing cardiovascular risks caused by PE.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anette Sams, Kristian Agmund Haanes, Anja Holm, Spyridoula Kazantzi, Lars Friis Mikkelsen, Lars Edvinsson, Susan Brain, Majid Sheykhzade
Summary: This study characterized the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries in Gottingen Minipigs (GM), and compared the responses to those obtained from parallel studies using other artery types. The results showed that different arterial sources had different responses to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways. The study also demonstrated the robust nature of the vasomotor responses after 24 hours of cold storage of vascular tissue.
VASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mimmi Rehnstrom, Hilda Ahnstedt, Diana N. Krause, Marie Louise Edvinsson, Kristian Agmund Haanes, Lars Edvinsson
Summary: This study found that sex hormones do not directly affect vasoconstrictive changes following ischemic stroke, but the loss of ovarian function does impact this process.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)