Article
Cell Biology
Zhongli Chen, Qiqi Xue, Lijuan Cao, Yanpin Wang, Yuanyuan Chen, Xiaojie Zhang, Fan Xiao, Ying Yang, Melvin R. Hayden, Yan Liu, Ke Yang
Summary: This study found that oxLDL induced the foam cell-like phenotype in VSMCs and led to lipid and ROS accumulation in a dose-dependent manner, with Tlr4 showing the strongest upregulation. Interfering with Tlr4 expression abolished phenotype alteration, lipid accumulation, and Src kinase activation induced by oxLDL, demonstrating Tlr4's critical role in foam cell formation via regulating Src kinase activation as well as Sirt1 and Sirt3 expression.
MEDIATORS OF INFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Lianghui Zhan, Jingru Zheng, Jianbiao Meng, Danting Fu, Lisha Pang, Chunlian Ji
Summary: This study found that TLR4 deficiency can reduce inflammatory responses and apoptosis, improve intestinal damage, regulate intestinal flora, and alleviate LPS-induced intestinal barrier dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Hiroshi Saito, Yuya Nakamura, Masahiro Inagaki, Shiho Yamadera, Hideo Misawa, Naoki Sato, Tatsunori Oguchi, Takae Inagaki, Yuya Tsuji, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh, Yuji Kiuchi
Summary: The study examined the anti-inflammatory effects of linagliptin in TLR4- and LBP-independent pathways, showing that linagliptin can suppress LPS-induced inflammation in a concentration-dependent manner.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Hematology
Carmen Yap, Arnout Mieremet, Carlie J. M. de Vries, Dimitra Micha, Vivian de Waard
Summary: Multiple layers of vascular smooth muscle cells (vSMCs) form the media of blood vessels, providing structure and regulating blood flow. vSMCs exhibit high plasticity and can switch between different phenotypes, with a total of 6 phenotypes identified. The central dedifferentiated vSMC type is the mesenchymal-like phenotype, which can differentiate into various other cell types contributing to vascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natsumi Ogawa, Shingo Nakajima, Kenya Tamada, Natsuki Yokoue, Haruki Tachibana, Miwa Okazawa, Takahiro Oyama, Hideaki Abe, Hiroaki Yamazaki, Atsushi Yoshimori, Akira Sato, Takanori Kamiya, Takehiko Yokomizo, Fumiaki Uchiumi, Takehiko Abe, Sei-ichi Tanuma
Summary: The spasmolytic drug trimebutine has shown potential as an anti-inflammatory agent in experiments, reducing the production of various proinflammatory factors and significantly decreasing mortality in a mouse model of sepsis. Studies have found that trimebutine exerts its anti-inflammatory effects by inhibiting TLR signaling pathways and NF-kappa B activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Ioanna Tsioti, Beatrice L. Steiner, Pascal Escher, Martin S. Zinkernagel, Peter M. Benz, Despina Kokona
Summary: Clustering of microglia around the vasculature was observed after systemic administration of lipopolysaccharides (LPS) in the retina and brain of mice. This study investigated the effect of systemic LPS in the pigmented mouse retina and the involvement of endothelial TLR4 in LPS-induced retinal microglia activation. The results showed that activation of microglia, infiltration of monocyte-derived macrophages, impaired ribbon synapse organization, and retinal dysfunction were observed after LPS exposure, and these effects were dependent on endothelial TLR4.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Ruonan Zhang, Xiaofeng Li, Jie Zhang, Yanjun Li, Yuan Wang, Yuhang Song, Feifei Ren, Huiyu Yi, Xiaojuan Deng, Yangjin Zhong, Yang Cao, Michael R. Strand, Xiao-Qiang Yu, Wanying Yang
Summary: Toll/Toll-like receptors play different roles in mammals and insects, with insects primarily activating the Toll pathway through binding Spatzle cytokines rather than directly recognizing pathogen-associated molecular patterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Fang Li, Haoran Ke, Siqi Wang, Wei Mao, Cexiong Fu, Xi Chen, Qingqing Fu, Xiaori Qin, Yonghua Huang, Bidan Li, Shibing Li, Jingying Xing, Minhui Wang, Wenlin Deng
Summary: Leaky gut could be a trigger for the development of autism by activating the lipopolysaccharide-mediated TLR4-MyD88-NF-kappa B pathway. Disrupting and repairing the intestinal barrier improved the behavior of autistic mice and reduced inflammation.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Sumei Liu, Guojing Liu, Qingxian Luan, Yongping Ma, Xiaoqian Yu
Summary: This study found that P. gingivalis stimulates B cells to produce IL-10 via TLR2/4, and the CD5+ B1 subset is the main source of IL-10+ Breg cells. Under P. gingivalis LPS stimulation, CD5+ IgM+ CD93-IL-10+ B cell subset increases significantly.
PROTEIN AND PEPTIDE LETTERS
(2022)
Article
Immunology
Wei Zhang, Eun-Koung An, Juyoung Hwang, Jun-O Jin
Summary: The study found that LPS can directly stimulate pDCs via the TLR4/MD2 pathway and promote the activation of pDCs and cDCs. cDCs may contribute to the enhancement of IFN-alpha production in pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sabrina Solorzano, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: The study reveals that IL-6, TLR2, and TLR4 have limited roles in immune-mediated BMF in mice, while adaptive immunity appears to be the major contributor to the disease.
Article
Cardiac & Cardiovascular Systems
Xiaolu Jiao, Huahui Yu, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Xiaoping Zhang, Qianwen Lv, Fan Li, Qiuju Sun, Yu Wang, Yanwen Qin
Summary: This study found that ANGPTL8 in vascular smooth muscle cells (VSMCs) plays an important role in AngII-induced hypertension and associated cardiovascular remodelling. ANGPTL8 may be a novel therapeutic target against pathological hypertension and hypertensive cardiovascular hypertrophy.
CARDIOVASCULAR RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Wan Xie, Yang Xue, Xiaokun Song, Hongzhu Zhang, Guangjun Chang, Xiangzhen Shen
Summary: This study found that LPS activates TLR4 and inhibits FOXA2 expression, leading to NF-kappa B-mediated inflammation, ER stress, autophagy, and apoptosis. Inhibiting TLR4 and increasing FOXA2 expression can alleviate LPS-induced inflammation, ER stress, autophagy, and apoptosis, maintaining cellular homeostasis.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Cimmino, Francesco Prisco, Sonia Orso, Ayewa L. Agognon, Pasquale Liguoro, Davide De Biase, Nunzianna Doti, Menotti Ruvo, Orlando Paciello, Francesco Beguinot, Pietro Formisano, Francesco Oriente
Summary: The study investigated the role of Prep1 in Prep1(i/+) mouse aorta and VSMCs, revealing that Prep1 reduces apoptosis by modulating Bcl-xL and p53 in both murine aorta and VSMCs. Additionally, the age-dependent increase in IL-6 and Prep1 in senescent VSMCs and old mice may be involved in aging-related vascular dysfunction.