Review
Medicine, General & Internal
Wagner Iared, Jose Eduardo Mourao, Andrea Puchnick, Fernando Soma, David Carlos Shigueoka
Summary: There is currently insufficient evidence to determine whether stenting is more effective than angioplasty alone for stenosis of the subclavian artery.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Caroline G. Pass, Victoria Palzkill, Jianna Tan, Kyoungrae Kim, Trace Thome, Qingping Yang, Brian Fazzone, Scott T. Robinson, Kerri A. O'Malley, Feng Yue, Salvatore T. Scali, Scott A. Berceli, Terence E. Ryan
Summary: This study presents a single-nuclei RNA-sequencing atlas of PAD limb muscle, revealing a shift in fiber type and upregulation of stress response, autophagy, hypoxia, and atrophy-related genes in PAD patients. Additionally, unique transcriptional profiles and increased diversity of transcriptomes were observed in muscle stem cells, regenerating myonuclei, and fibro-adipogenic progenitor cells of PAD muscles. Analysis of intercellular communication networks highlighted fibro-adipogenic progenitors as a major signaling hub in PAD muscle, along with deficiencies in angiogenic and bone morphogenetic protein signaling which could contribute to poor limb function in PAD.
CIRCULATION RESEARCH
(2023)
Article
Surgery
Jacob Cleman, Gaelle Romain, Scott Grubman, Raul J. Guzman, Kim G. Smolderen, Carlos Mena-Hurtado
Summary: This study examined the association between revascularization surgery and peripheral vascular intervention in patients with chronic limb-threatening ischemia (CLTI), and found that revascularization surgery was associated with a lower risk of 30-day amputation and 5-year all-cause mortality.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Shigeyuki Sakamoto, Masaru Abiko, Yosuke Kajihara
Summary: The inflation of a balloon-guiding catheter inside the aortic arch at the left subclavian artery origin provides a simple and potentially safe technique for cerebral protection during left subclavian artery stenting.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Yui Kambayashi, Ken Iseri, Tomoki Morikawa, Atushi Yao, Akio Yokochi, Hirokazu Honda
Summary: This study aimed to investigate the risk factors for blood vessel rupture during vascular access intervention therapy. Findings revealed that receiving treatment for the first time and a high resistance index were significantly associated with a high risk for rupture. Therefore, heightened surveillance is necessary during vascular access intervention therapy, particularly for first-time patients or those with a high resistance index.
Article
Biotechnology & Applied Microbiology
Hui Su, Shengyuan Yu, Chenglin Tian, Zhihua Du, Xinfeng Liu, Jun Wang, Xiangyu Cao
Summary: This study investigated factors associated with in-stent restenosis (ISR) after vertebral artery ostium (VAO) stenting and found that stenting is an effective treatment for VAOS. The angle of the VAO at the subclavian artery may contribute to the development of ISR.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Arne M. Mueller, Justus Bertram, Christian Bradaric, Tobias Koppara, Salvatore Cassese, Erion Xhepa, Britta Heilmeier, Ilka Ott, Adnan Kastrati, Karl-Ludwig Laugwitz, Tareq Ibrahim, Ralf J. Dirschinger
Summary: This retrospective multicenter study analyzed patient records of internal mammary artery coronary bypass patients undergoing coronary angiography and found that subclavian artery stenosis was a relevant finding in these patients. Among the patients with severe stenosis, 32% underwent endovascular or surgical revascularization. Developing dedicated algorithms for screening and ischemia evaluation may improve treatment for this potentially underdiagnosed and undertreated condition.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Byoung Geol Choi, Ji-Yeon Hong, Seung-Woon Rha, Cheol Ung Choi, Michael S. Lee
Summary: Routine coronary angiography (CAG) in peripheral arterial disease (PAD) patients undergoing percutaneous transluminal angioplasty (PTA) may not provide a significant advantage in predicting long-term survival compared to PAD patients without CAD. While PAD patients with CAD showed no significant difference in mortality compared to those without CAD, they were more likely to undergo repeat percutaneous coronary intervention (PCI). Routine CAG and subsequent PCI, if needed, may be a reasonable strategy for reducing mortality risk in PAD patients.
Review
Nutrition & Dietetics
Ahmed Ismaeel, K. Leigh Greathouse, Nathan Newton, Dimitrios Miserlis, Evlampia Papoutsi, Robert S. Smith, Jack L. Eidson, David L. Dawson, Craig W. Milner, Robert J. Widmer, William T. Bohannon, Panagiotis Koutakis
Summary: PAD affects over 200 million people worldwide, resulting in significant functional decline, with limited treatment options. Phytochemicals may have therapeutic effects on functional outcomes in PAD patients.
Article
Biochemistry & Molecular Biology
Janina Krug, Magdalena L. Bochenek, Rajinikanth Gogiraju, Dagmar Laubert-Reh, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild, Christine Espinola-Klein, Katrin Schaefer
Summary: This study found that circulating sEPCR levels may serve as biomarkers of endothelial dysfunction, including angiogenesis, in individuals older than 35 years, and progressive loss of endothelial protein C receptors might be involved in the development and progression of PAD.
Review
Cardiac & Cardiovascular Systems
Isma N. Javed, Beau M. Hawkins
Summary: Aorto-iliac disease is a common manifestation of atherosclerosis, with treatment options including medication, risk factor modification, exercise, and revascularization for severe cases. Various endovascular therapies are now available for complex lesions.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerd Groezinger, Jan Hallecker, Ulrich Grosse, Roland Syha, Dominik Ketelsen, Klaus Brechtel, Mario Lescan, Konstantin Nikolaou, Christoph Artzner
Summary: This study evaluated the safety and effectiveness of tibiopedal and distal femoral access for retrograde crossing of chronic total occlusion in peripheral arterial occlusive disease patients. The technical success rate was 82%, but severe calcification was found to be associated with decreased technical success.
EUROPEAN RADIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Tanner I. Kim, Raul J. Guzman
Summary: Medial artery calcification (MAC) is a regulated process associated with age, diabetes, and chronic kidney disease. It often occurs with atherosclerotic occlusive disease in lower extremity arteries, leading to negative limb outcomes. In patients with peripheral artery disease (PAD), MAC independently correlates with major amputation and mortality rates, affecting outcomes after endovascular interventions. Understanding the role of medial calcification in PAD and developing strategies for patient outcomes improvement are areas for further investigation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Jonathan D. Newman, MacIntosh G. Cornwell, Hua Zhou, Caron Rockman, Adriana Heguy, Yajaira Suarez, Henry S. Cheng, Mark W. Feinberg, Judith S. Hochman, Kelly Ruggles, Jeffrey S. Berger
Summary: A transcriptomic signature identified patients with symptomatic PAD and those at increased risk of major adverse cardiac or limb events (MACLE). A specific microRNA, microRNA-4477b, was found to be overexpressed in prevalent PAD, incident MACLE, and in a mouse hindlimb ischemia model. This novel signature provides insights into potential mechanisms of severe symptomatic PAD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)