Article
Chemistry, Multidisciplinary
Benjamin T. Ledford, Adam W. Akerman, Kui Sun, David C. Gillis, Jenna M. Weiss, Johnny Vang, Smaranda Willcox, Tristan D. Clemons, Hiroaki Sai, Ruomeng Qiu, Mark R. Karver, Jack D. Griffith, Nick D. Tsihlis, Samuel Stupp, John S. Ikonomidis, Melina R. Kibbe
Summary: This study reports the development of injectable supramolecular nanofibers that target fragmented elastin, matrix metalloproteinase 2, and membrane type 1 matrix metalloproteinase to reduce the risks associated with a ruptured abdominal aortic aneurysm. The results show that one of the nanofibers was able to better localize to the aneurysm tissue and had an optimal dose.
Review
Medicine, General & Internal
Andres Schanzer, Gustavo S. Oderich
Summary: Repair of abdominal aortic aneurysm is recommended in men with an aneurysm of 5.5 cm or more and in women with an aneurysm of 5.0 cm or more. Endovascular aortic aneurysm repair has lower risk of perioperative complications and death compared to open surgical repair, but there is no long-term survival advantage. Long-term imaging surveillance is recommended after endovascular repair.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Yu Fu, Haole Liu, Kexin Li, Panpan Wei, Naqash Alam, Jie Deng, Meng Li, Haibin Wu, Xue He, Haiwen Hou, Congcong Xia, Rong Wang, Weirong Wang, Liang Bai, Baohui Xu, Yankui Li, Yi Wu, Enqi Liu, Sihai Zhao
Summary: CRP deficiency suppresses AAA by reducing aneurysmal elastin destruction, macrophage accumulation, and matrix metalloproteinase 2 expression
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David Yule, Larry E. Wagner, John M. Ashton, Ayman Elbadawi, Scott J. Cameron
Summary: Biomechanical platelet activation may be a potential mechanism behind resistance to antiplatelet medication. A study on patients with abdominal aortic aneurysms (AAA) found that activation of olfactory receptor pathway is associated with AAA progression. A molecule activating platelet olfactory receptor was identified and shown to inhibit platelet activation and AAA growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Surgery
J. Michael Cullen, Alexander H. Shannon, Guanyi Lu, Gang Su, Michael D. Spinosa, William G. Montgomery, Gorav Ailawadi, Morgan Salmon, Gilbert R. Upchurch
Summary: The study on swine experiments revealed that female pigs have a higher dilation rate in forming abdominal aortic aneurysms, while uncastrated male pigs exhibit larger aneurysm size and elastin degradation.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Hematology
Xia Guo, Dunpeng Cai, Kun Dong, Chenxiao Li, Zaiyan Xu, Shi-You Chen
Summary: DOCK2 is identified as a novel regulator for AAA formation, playing a role in promoting vascular inflammation and elastin degradation by upregulating MCP-1 and MMP2 expression.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Christiana Lowis, Aurellia Ramara Winaya, Puja Kumari, Cristobal F. Rivera, John Vlahos, Rio Hermantara, Muhammad Yogi Pratama, Bhama Ramkhelawon
Summary: Cumulative evidence supports the idea that mechanical and frictional forces have distinct effects in the aortic layers and contribute to the development of abdominal aortic aneurysms (AAA). Mechanosensory cellular hubs play a crucial role in triggering signaling cascades that lead to the degradation of the extracellular matrix (ECM), resulting in aortic rupture. This review provides an overview of the current understanding of the mechanotransduction networks in different cell types during AAA development, focusing on the mechanosensors and stressors that accumulate in the AAA sac and their effects on inflammation, oxidative stress, remodeling, and ECM degradation. Manipulating this mechano-machinery could be a promising direction for future AAA research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Lisa Adams, Julia Brangsch, Bernd Hamm, Marcus R. Makowski, Sarah Keller
Summary: This review outlines recent advances in molecular imaging of abdominal aortic aneurysms (AAA) with a focus on the extracellular matrix (ECM) and discusses the development of pharmacologic treatments targeting ECM. Molecular imaging techniques can assist in early detection of AAA and drive the development of novel diagnostic and therapeutic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher T. Sciria, Benedict Osorio, Joseph Wang, Daniel Y. Lu, Nivee Amin, Adam Vohra, Ilhwan Yeo, Dmitriy N. Feldman, Jim W. Cheung, Nupoor Narula, S. Chiu Wong, Luke K. Kim
Summary: Although AAA is more common in men, women with AAA have increased morbidity and mortality. Discrepancies exist among professional society guidelines for AAA screening in women. Female gender is a significant predictor of death in both rupture and elective repair of AAA, with women more likely to die before repair in the rupture group.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Bartosz Pilecki, Paulo V. S. D. de Carvalho, Katrine L. Kirketerp-Moller, Anders Schlosser, Karin Kejling, Magdalena Dubik, Nicklas P. Madsen, Jane Stubbe, Pernille B. L. Hansen, Thomas L. Andersen, Jesper B. Moeller, Niels Marcussen, Vasco Azevedo, Svend Hvidsten, Christina Baun, Guo-Ping Shi, Jes S. Lindholt, Grith L. Sorensen
Summary: MFAP4 plays a crucial role in promoting the development of AAA by inducing macrophage-rich inflammation and MMP activity within the vessel wall. Its deficiency leads to reduced AAA incidence and ameliorates pathological changes in AAA, implicating regulation of monocyte influx and MMP production as key mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, Research & Experimental
Lauren M. Weaver, Charles D. Loftin, Chang-Guo Zhan
Summary: This article discusses drugs for the treatment of abdominal aortic aneurysms (AAA) that have been studied in clinical trials. It examines the drug targets and their ability to regulate the three key pathways involved in AAA progression. The article highlights the historical use of repurposed therapeutics in interventional clinical trials and the need for novel treatments to reach the clinic. It emphasizes the importance of centralized anti-inflammatory drug targets and translatability in AAA treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Guizhen Zhao, Ziyi Chang, Yang Zhao, Yanhong Guo, Haocheng Lu, Wenying Liang, Oren Rom, Huilun Wang, Jinjian Sun, Tianqing Zhu, Yanbo Fan, Lin Chang, Bo Yang, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Summary: The study indicates that endothelial KLF11 plays an important role in maintaining vascular homeostasis, with its deficiency exacerbating AAA formation and overexpression inhibiting AAA occurrence. KLF11 not only inhibits endothelial cell inflammatory response, but also reduces the production of reactive oxygen species, exerting a protective effect against AAA.
Article
Peripheral Vascular Disease
Athina Goliopoulou, Evangelos Oikonomou, Alexis Antonopoulos, Nikolaos Koumallos, Maria Gazouli, Panagiotis Theofilis, Vasiliki-Chara Mystakidi, Panteleimon Pantelidis, Michael-Andrew Vavuranakis, Gerasimos Siasos, Dimitris Tousoulis
Summary: Little is known about the role of serum and tissue mediators in the progression of ascending aortic aneurysms and dissections. This study examined the tissue expression of microRNAs and matrix metalloproteinases (MMPs), as well as the serum levels of osteoprotegerin, adiponectin, and high sensitivity C-reactive protein (hsCRP) in relation to these conditions. The findings suggest that microRNAs may contribute to the progression of aneurysm formation and dissection, indicating their potential as biomarkers and therapeutic targets.
Article
Biochemistry & Molecular Biology
Daniel Koerfer, Philipp Erhart, Susanne Dihlmann, Maani Hakimi, Dittmar Boeckler, Andreas S. Peters
Summary: The aim of this study was to investigate the histopathological differences in abdominal aortic aneurysms (AAAs) between patients with multiple and single arterial aneurysms. The study found that IL-1 beta was significantly more present in the tunica media in patients with multiple arterial aneurysms compared to those with a single AAA. This suggests that inflammatory processes play a role in aneurysm formation in patients with multiple arterial aneurysms.