Journal
VASCULAR
Volume 17, Issue -, Pages S2-S9Publisher
SAGE PUBLICATIONS LTD
DOI: 10.2310/6670.2008.00083
Keywords
remodeling; systems biology; vein graft hemodynamics
Categories
Funding
- National Institutes of Health [1 K08 HL04070]
- American Heart Association [065354N]
- Lifeline Foundation
- The William J. von Liebig Foundation
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Despite intense investigation over several decades to understand the mechanisms of vein graft failure, few therapeutic modalities have emerged. Emphasis using standard reductionist approaches has been focused on cataloging the components involved in the early events following vein graft implantation, but limited insight has been gained in understanding the dynamic interaction of these components. We propose that the application of systems theory offers the opportunity for significant advances in this area. Focused on modeling the dynamic relationships that define living organisms, systems biology provides the necessary tools to further our understanding of the complex series of overlapping biologic events on surgical implantation of the vein graft. Through the use of ordinary differential equation and agent-based modeling techniques, we present our ongoing efforts to define the nonlinear interactions between hemodynamics and vascular adaptation.
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