Article
Economics
Cormac Kennedy, Laura McCullagh, Roisin Adams, Lea Trela-Larsen, Lesley Tilson, Michael Barry
Summary: This study estimates the theoretical excess expenditure that would occur if drugs were reimbursed at their original list price instead of a cost-effective price. It highlights the importance of evaluating the value of new drugs to identify potential excess drug expenditure.
Article
Pharmacology & Pharmacy
Pu Ge, Ning Wan, Xiao Han, Xinpei Wang, Jinzi Zhang, Xiaoyi Long, Xiaonan Wang, Ying Bian
Summary: This study evaluated the efficacy, safety, and cost-effectiveness of aflibercept for the treatment of mCRC, aiming to provide a decision-making reference for the selection of targeted drugs for second-line treatment of mCRC in the Hong Kong, Macao, and Taiwan regions of China, as well as the selection of new drugs for medical institutions in these regions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Economics
Peter J. Neumann, Meghan I. Podolsky, Anirban Basu, Daniel A. Ollendorf, Joshua T. Cohen
Summary: This study investigated how health technology assessment (HTA) organizations worldwide have addressed drug genericization in cost-effectiveness analyses (CEAs). It analyzed a large sample of published CEAs and found that the majority of these studies did not consider assumptions about future generic prices for drugs, potentially leading to misrepresentation of long-term opportunity costs. The study highlights the need for clearer guidance on when CEAs should account for genericization and include other price dynamics.
Article
Pharmacology & Pharmacy
Antonia Agusti, Gloria Cereza, Francisco J. de Abajo, Miguel A. Macia, Jose A. Sacristan
Summary: Clinical pharmacology should shift its focus from drug-individual interaction to drug-individual-society interaction and analyze the clinical and economic consequences of drug use in clinical practice. The current technological development offers an opportunity for exploration in other areas of interest.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Francesc Lopez, Marti Catala, Clara Prats, Oriol Estrada, Irene Oliva, Nuria Prat, Mar Isnard, Roser Valles, Marc Vilar, Bonaventura Clotet, Josep Maria Argimon, Anna Aran, Jordi Ara
Summary: The study shows that the mass vaccination campaign against COVID is cost-saving, with significant savings coming from the monetization of the reduction in mortality and cases with sequelae from a social perspective. The intervention is widely cost-effective from the health system perspective as well due to the reduction in the use of resources. From an economic perspective, the vaccination campaign has high social returns.
Article
Health Care Sciences & Services
Hansoo Kim, Danny Liew, Stephen Goodall
Summary: This study aimed to bridge the gap in opinions between manufacturers and payers regarding health technology assessment (HTA) in reimbursement submission for oncology drugs. The survey found that private and public sector respondents had similar views on clinical claims, but were divided on the extrapolation of survival data and costs and health resource utilization. The study also identified challenges and research opportunities for HTA in oncology.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2022)
Article
Oncology
G. Chauca Strand, C. Bonander, N. Jakobsson, N. Johansson, M. Svensson
Summary: This study describes the clinical and cost-effectiveness evidence supporting reimbursement decisions of new cancer drugs in Sweden and analyzes the influence of trial characteristics and cost per quality-adjusted life years (QALYs) on the likelihood of reimbursement. The results show substantial uncertainties in the evidence underlying reimbursement decisions and emphasize the importance of cautious decision-making considering limited evidence on patient-centered outcomes and the implications of allocating resources to expensive treatments with uncertain value for money.
Review
Medicine, Research & Experimental
Daniel Juarez-Lopez, Alejandro Schcolnik-Cabrera
Summary: Drug repurposing is an attractive option for treating diseases, but there are challenges such as focusing on specific diseases, lack of options for orphan diseases, legal concerns, and challenges in clinical trials.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Economics
Joshua T. Cohen
Summary: This article investigates whether anticipated future price declines should be considered in health technology assessments and how it can affect cost-effectiveness estimates. Through 4 case studies, it is found that generic pricing should be included for subsequent cohorts, but can be omitted for reimbursement assessments. Accounting for generic pricing can significantly reduce estimated cost-effectiveness ratios.
Article
Public, Environmental & Occupational Health
D. Ismail
Summary: Evaluation of global antibiotic consumption and cost: A retrospective observational study. The study assessed the consumption and cost of antibiotics, particularly in intensive care units, and found that antibiotic consumption was lower for community-acquired infections and higher for nosocomial and multidrug-resistant infections.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Medicine, General & Internal
N. Ipek Kirmizi Sonmez, Volkan Aydin, Omer Atac, Ahmet Akici
Summary: This study suggests that physicians with a higher tendency to prescribe without clear indications are more likely to produce costly prescriptions.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Francesco Moretti, Fabrice Ruiz, Fedele Bonifazi, Elena Pizzo, Jenny M. Kindblom
Summary: The development of medicines in paediatrics is complex and challenging, requiring attention to safety, efficacy, and quality. National health technology assessments play a crucial role in determining access to treatments, and assessing new paediatric treatments is a critical issue. This article explores the drug development process in paediatrics, particularly focusing on health technology assessments and their impact on market access and patient treatment. It also highlights methodological challenges in conducting health technology assessments in the paediatric field.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Social Issues
Vuk Uskokovic
Summary: Different regions show significant differences in the treatment methods and effectiveness of multidrug-resistant bacterial pathogens, highlighting the need for tailoring therapies to specific regions.
TECHNOLOGY IN SOCIETY
(2021)
Article
Health Care Sciences & Services
Yun Kim, Soohyun Kim, Jinsook Park, Howard Lee
Summary: This study evaluated the cost-effectiveness of vancomycin therapeutic drug monitoring in elderly patients in Korea, finding that while the TDM group had significantly lower total medical and medication expenses compared to the non-TDM group, there was no significant difference in clinical outcomes between the two groups.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Microbiology
Ai Leng Khoo, Ying Jiao Zhao, Glorijoy Shi En Tan, Monica Teng, Jenny Yap, Paul Anantharajah Tambyah, Chin Hin Ng, Boon Peng Lim, Louis Yi Ann Chai
Summary: The study found that combining mould-active prophylaxis with routine GM monitoring is more cost-effective and effective for treating invasive aspergillosis, reducing costs and increasing patients' QALYs gained. The use of empiric antifungal treatment has a significant impact on cost-effectiveness.
Article
Multidisciplinary Sciences
Seung Yeol Lee, Deog Young Kim, Min Kyun Sohn, Jongmin Lee, Sam-Gyu Lee, Yong-Il Shin, Soo-Yeon Kim, Gyung-Jae Oh, Young Hoon Lee, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Jeonghoon Ahn, Won Hyuk Chang, Ji Yoo Choi, Sung Hyun Kang, Il Yoel Kim, Junhee Han, Yun-Hee Kim
Article
Clinical Neurology
Minyoung Shin, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Min A. Shin, Ji Yoo Choi, Sung Hyun Kang, Youngtaek Kim, Yun-Hee Kim
Article
Rehabilitation
Min-Su Kim, Min Cheol Joo, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Soo-Yeon Kim, Gyung-Jae Oh, Yang-Soo Lee, Eun Young Han, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Yun-Hee Kim, Ji Yoo Choi, Sung Hyun Kang, Young Taek Kim
TOPICS IN STROKE REHABILITATION
(2020)
Article
Mathematical & Computational Biology
Hyungtai Kim, Minhee Lee, Min Kyun Sohn, Jongmin Lee, Deog Yung Kim, Sam-Gyu Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Ji Yoo Choi, Sung Hyun Kang, Dong Han Lee, Young Taek Kim, Mun-Taek Choi, Yun-Hee Kim
JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS
(2020)
Editorial Material
Health Care Sciences & Services
Jing Lou, K. C. Sarin, Kai Yee Toh, Saudamini Dabak, Amanda Adler, Jeonghoon Ahn, Diana Beatriz S. Bayani, Kelvin Chan, Dechen Choiphel, Brandon Chua, Anne Julienne Genuino, Anna Melissa Guerrero, Brendon Kearney, Lydia Wenxin Lin, Yuehua Liu, Ryota Nakamura, Fiona Pearce, Shankar Prinja, Raoh-Fang Pwu, Asrul Akmal Shafie, Binyan Sui, Auliya Suwantika, Yot Teerawattananon, Sean Tunis, Hui-Min Wu, John Zalcberg, Kun Zhao, Wanrudee Isaranuwatchai, Hwee-Lin Wee
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2020)
Article
Rehabilitation
Nayeon Ko, Hyun Haeng Lee, Min Kyun Sohn, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Soo Mi Choi, Seon Kui Lee, Jongmin Lee, Yun-Hee Kim
Summary: The study identified that the incidence of dysphagia after ischemic stroke was 32.3%. Predictive factors for the presence of dysphagia included age, low BMI, premorbid disabilities, brainstem lesions, and NIHSS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Hyun Haeng Lee, Deog Young Kim, Min Kyun Sohn, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Ilyoel Kim, Soo Mi Choi, Jongmin Lee, Yun-Hee Kim
Summary: This study validated the proportional recovery model by analyzing the medical records of stroke patients in Korea, identifying clinical factors contributing to the ceiling effect of the Fugl-Meyer Assessment score, and demonstrating variations in recovery proportion based on initial motor deficits of the upper limb. The findings suggest that the proportional recovery model may not be valid for all stroke patients.
Article
Health Care Sciences & Services
Zhihao Yang, Fredrick Dermawan Purba, Asrul Akmal Shafie, Ataru Igarashi, Eliza Lai-Yi Wong, Hilton Lam, Hoang Van Minh, Hsiang-Wen Lin, Jeonghoon Ahn, Juntana Pattanaphesaj, Min-Woo Jo, Vu Quynh Mai, Jan Busschbach, Nan Luo, Jie Jiang
Summary: This study compares the health preferences among 11 Asian populations using DCE data collected in their EQ-5D-5L valuation studies. The findings suggest that there are considerable differences in modeling and relative importance results among these populations, advocating for the use of local value sets.
QUALITY OF LIFE RESEARCH
(2022)
Article
Medical Informatics
Jah Yeon Choi, Ji Bak Kim, Sunki Lee, Seo-Joon Lee, Seung Eon Shin, Se Hyun Park, Eun Jin Park, Woohyeun Kim, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Jeonghoon Ahn, Hyun-Ghang Jeong, Eung Ju Kim
Summary: Despite the underutilization of cardiac rehabilitation (CR) programs, the development of a smartphone-based messaging app for patients who have undergone percutaneous coronary intervention (PCI) was successful. Feedback on the app was positive, and user ratings for readability and usefulness were high, resulting in refinement of messages to cater to individual patient needs.
JMIR MEDICAL INFORMATICS
(2021)
Article
Health Care Sciences & Services
Minyoung Shin, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Seyoung Shin, Soo Mi Choi, Seon Kui Lee, Yun-Hee Kim
Summary: This study investigated the impact of post-stroke depression (PSD) on cognitive aging in elderly stroke patients. The results showed that early PSD increased the risk of cognitive decline in older stroke patients, mainly in males. Older male patients with negative thinking were at increased risk of cognitive decline, and older women may also be at risk for cognitive decline.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Hongmin Chu, Bo-Hyoung Jang, GaYoon Kim, Seowoo Bae, Hyeju Lee, Seonghee Nam, Jeonghoon Ahn
Summary: The present study aims to evaluate the comparative treatment effect and prevention of re-fracture according to the type of bisphosphonate (BP) in glucocorticoid-induced osteoporosis (GIOP) patients, providing a reliable clinical strategy.
Article
Primary Health Care
Mi-Ra Cho, Yu-Jin Kwon, Shin-Hye Kim, Jinseub Hwang, Jimin Kim, Jangmi Yang, Jeonghoon Ahn, Jae-Yong Shim
Summary: This study evaluated the practicality of ICPC-2 in Korean primary care and found that it can be a feasible complementary means for diagnosing common diseases.
KOREAN JOURNAL OF FAMILY MEDICINE
(2022)
Article
Infectious Diseases
Kyoung-Ho Song, Chung-Jong Kim, Nam-Kyong Choi, Jeonghoon Ahn, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Hee Jung Choi, Ji Yun Bae, Eu Suk Kim, Hyunju Lee, Jeong Su Park, Younghee Jung, Seung Soon Lee, Kyung-Hwa Park, Sook-In Jung, Yeon-Sook Kim, Ji-Hwan Bang, Shinwon Lee, Yu Min Kang, Yee Gyung Kwak, Hong Bin Kim
Summary: This study aimed to investigate the socioeconomic and clinical burden of multidrug-resistant organisms (MDRO), such as MRSA, VRE, MRAB, MRPA, and CRE. The study found that MDRO bacteremia caused a significant clinical and economic burden.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Surgery
Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee
Summary: This study based on Korea national administrative claims data found that drug-coated devices used in femoropopliteal artery revascularization did not increase all-cause mortality risk. Adjusted hazard ratios showed that drug-coated devices were associated with decreased all-cause mortality risk.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Meeting Abstract
Clinical Neurology
Yu Min Bang, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-gyu Lee, Yong-il Shin, Gyung-jae Oh, Yang-soo Lee, Min Cheol Joo, So Young Lee, Junhee Han, Jeonghoon Ahn, Young-hoon Lee, Min-keun Song, Won Hyuk Chang, Soo Mi Choi, Jin Ha, Yun-Hee Kim
CEREBROVASCULAR DISEASES
(2020)