Article
Immunology
Marco Fonzo, Chiara Bertoncello, Andrea Trevisan
Summary: This study aimed to assess long-term protection 10-20 years after primary HBV vaccination and investigate the effects of age at first dose, sex, and time between doses. The results showed that early vaccination had a better long-term protective effect, while the impact on vaccination in adolescence was not significant.
Article
Biotechnology & Applied Microbiology
Wen Ren, Jing Li, Ruidong Cheng, Zikang Wu, Ying Liu, Yan Qiu, Jun Yao, Jingjing Ren
Summary: The study aimed to evaluate the immunogenicity and persistence of antibodies in adults 8 years after vaccination, finding that isolated anti-HBc-positive subjects could achieve satisfactory long-term immune effects after hepatitis B vaccination, with no significant difference in antibody titers between isolated anti-HBc and control groups after 8 years.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Yonas Bekele, Jay A. Berzofsky, Francesca Chiodi
Summary: HIV-1-infected individuals exhibit suboptimal response to HBV vaccines and poor maintenance of protective immunity, necessitating interventions based on factors such as CD4+ T cell counts, B cell response, vaccine formulation, and timing of administration. The initial response to HBV vaccination is crucial for sustaining antibody responses in both infected and uninfected individuals, highlighting the importance of regular follow-up and booster doses to prevent HBV transmission in HIV-1 infected people.
Article
Biotechnology & Applied Microbiology
Yan Qiu, Zi-Kang Wu, Jie Wu, Jun Yao, Ying Liu, Wen Ren, Yu-Jing Sun, Ling-Zhi Shen, Jing-Jing Ren
Summary: This study aimed to quantify the persistence of the immune response after booster vaccination against hepatitis B through mathematical modeling. The study found that the immunogenicity of the booster vaccination could persist for at least 8 years, with the mathematical model predicting protection for up to 30 years.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Xiaodan Wang, Jia Luo, Fubao Ma, Guodong Kang, Zhengrong Ding, Yue Pan, Yujiao Zhao, Junying Chen, Kai Feng, Lingmei Yan, Juan Zhang, Linhao Li, Qiangping Lan, Daiying Li, Xiaolei Yang, Guoliang Li, Jingsi Yang, Qiangming Sun
Summary: This study compared the safety, immunogenicity, and immune persistence of hepatitis A vaccines between HBs-Ag-positive and -negative participants. Results showed that both types of vaccines were safe and provided excellent long-term protection against HAV for HBs-Ag-positive individuals.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chen-Hsuan Wu, Wei-Cheng Huang, Chien-Hung Chen, Sheng-Nan Lu
Summary: There is a high HBV infection rate and HBsAg carrier rate among high-risk Taiwanese children even after receiving HBIG and HB vaccinations. Cesarean section may protect newborns from becoming HBsAg carriers.
BIOMEDICAL JOURNAL
(2022)
Article
Immunology
Yun Shan Goh, Siew-Wai Fong, Angeline Rouers, Zi Wei Chang, Matthew Zirui Tay, Jean-Marc Chavatte, Nicole Ziyi Zhuo, Pei Xiang Hor, Chiew Yee Loh, Yuling Huang, Joel Xu En Wong, Yong Jie Tan, Daniel Rui Xiang Lim, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Raphael Tze Chuen Lee, Surinder Pada, Louisa Jin Sun, Desmond Luan Seng Ong, Jyoti Somani, Eng Sing Lee, Sebastian Maurer-Stroh, Cheng- Wang, Yee-Sin Leo, Raymond T. P. Lin, Ee Chee Ren, David C. Lye, Barnaby Edward Young, Poh Lian Lim, Lisa F. P. Ng, Laurent Renia
Summary: This study found that individuals who have received mRNA vaccines can choose to receive two doses of CoronaVac as booster shots, but an additional dose may be necessary for full protection, especially against newly emerged immune escape variants such as Omicron.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Immunology
Kana Shiraishi, Osamu Yoshida, Yusuke Imai, Sheikh Mohammad Fazle Akbar, Takahiro Sanada, Michinori Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Julio Cesar Aguilar Rubido, Gerardo Guillen Nieto, Yoichi Hiasa
Summary: This study found that CVP-NASVAC has prophylactic capacity for HB vaccine non-responders. After administration of CVP-NASVAC, patients were able to produce antibodies, and the neutralizing activity in sera was also confirmed. In addition, CVP-NASVAC also induced the generation of specific cytotoxic T lymphocytes.
Article
Oncology
Prasanth Varikkattu Rajendran, Priyakumari Thankamony, Binitha Rajeswari, Guruprasad Chellapan Sojamani, Manjusha Nair, Kusumakumary Parukuttyamma, Jagathnath Krishna Km
Summary: This study evaluated the loss of protective anti-hepatitis B (HBs) titers and seroconversion to hepatitis B vaccine (HBV) in children with acute lymphoblastic leukemia (ALL) during chemotherapy. The results showed that HBV boosters helped maintain protective titers in immunized children, especially if their titers were more than 100 mIU/L. For titers between 11 and 100 mIU/L, combined active and passive immunization may be required. Patients who fail to attain protective titers may need frequent doses of HBIG.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Multidisciplinary Sciences
Sabina Zurac, Cristian Vladan, Octavian Dinca, Carolina Constantin, Monica Neagu
Summary: This study aims to evaluate the waning of immune response after vaccination in SARS-CoV-2 infected individuals, particularly healthcare workers. The research found that the humoral response, measured by specific IgG and IgA antibodies, decreased 2.4 times for IgG and 2.7 times for IgA after 8 months post-vaccination. However, no documented infections were observed in the group. After the booster shot, the levels of IgG increased immediately, followed by an increase in specific IgA.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Joao Marcello de Araujo-Neto, Gabriela Sousa Guimaraes, Flavia Ferreira Fernandes, Marcelo A. Soares
Summary: Two prospective studies suggest that rituximab-treated patients with anti-HBs titers >= 100 mIU/mL before immunosuppression do not experience hepatitis B reactivation, and patients with no previous contact with HBV do not seroconvert after receiving HBV vaccine before rituximab chemotherapy.
Article
Immunology
Sanja Zember, Kristian Bodulic, Natasa Cetinic Balent, Radojka Mikulic, Alemka Markotic, Oktavija Dakovic Rode
Summary: The study found that antibody levels after COVID-19 vaccination decline rapidly, highlighting the need for booster doses to maintain immune effectiveness. Post-booster vaccination, antibody titers increased more rapidly and lasted longer.
Article
Public, Environmental & Occupational Health
Jannatin Nisa Arnindita, Muhammad Miftahussurur, Bagus Setyoboedi, Juniastuti
Summary: The study found that the rate of booster vaccination is low among children under 5 years of age in Indonesia, but is associated with anti-HBs positivity. It is recommended to administer booster vaccination to children to improve anti-HBs seropositivity.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2021)
Article
Immunology
Biyan Zhang, Jianxin Huo, Yuhan Huang, Shuan Yong Teo, Kaibo Duan, Yanfeng Li, Lim Kai Toh, Kong Peng Lam, Shengli Xu
Summary: In individuals vaccinated with either two prior doses of mRNA or inactivated virus vaccine, a booster dose of mRNA vaccine enhances humoral responses against the Omicron variant, providing potentially more effective protection against SARS-CoV-2 infection.
Article
Gastroenterology & Hepatology
Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J. Thompson, Peter A. Revill, P. Mark Hogarth, Bruce D. Wines, Renae Walsh, Nadia Warner
Summary: This study identified key anti-HBs profiles associated with either functional cure or failure to achieve functional cure in patients with chronic hepatitis B, suggesting a role for anti-HBs responses in functional cure.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Federica Chiara, Stefano Indraccolo, Andrea Trevisan
Summary: Over the past two decades, studies have linked tumor onset to environmental exposure to carcinogens, shifting focus from solely mutational burden to a more complex understanding of the factors involved in tumor formation. Consequently, traditional risk assessment strategies based on the 'mutator model' require urgent updates in order to keep pace with advances in our understanding of cancer biology.
Article
Oncology
Andrea Errico, Anna Stocco, Vincent M. Riccardi, Alberto Gambalunga, Franco Bassetto, Martina Grigatti, Amedeo Ferlosio, Gianluca Tadini, Debora Garozzo, Stefano Ferraresi, Andrea Trevisan, Sandra Giustini, Andrea Rasola, Federica Chiara
Summary: Neurofibromatosis type 1 is a genetic disease that predisposes to tumors of the nervous system, primarily neurofibroma. Research has shown that cell-cell cooperativity and the dynamics of the extracellular matrix play important roles in the progression of the disease, and treatment with MEK and FAK inhibitors has shown promise in abolishing the transforming ability of Pnf cells.
Article
Immunology
Silvia Cocchio, Vincenzo Baldo, Anna Volpin, Marco Fonzo, Annarosa Floreani, Patrizia Furlan, Paola Mason, Andrea Trevisan, Maria Luisa Scapellato
Summary: Vaccination is the most effective measure to prevent hepatitis B, and this study found that healthcare workers exposed to occupational risk for hepatitis B have long-term protective antibody titers after receiving HBV vaccines, especially if their initial titer was above 100 mIU/mL.
Article
Immunology
Andrea Trevisan, Paola Mason, Annamaria Nicolli, Stefano Maso, Bruno Scarpa, Angelo Moretto, Maria Luisa Scapellato
Summary: Vaccination schedule and sex have an impact on the immune response to measles vaccination, with one dose of measles vaccine alone being more effective than one and two doses of MMR.
Article
Virology
Andrea Trevisan, Angelo Moretto, Chiara Bertoncello, Annamaria Nicolli, Stefano Maso, Maria Luisa Scapellato, Paola Mason
Summary: The research showed that vaccination against mumps becomes more effective after two doses, especially for students born after 1995. Females tend to have a higher proportion of positive antibodies after vaccination compared to males.
Article
Environmental Sciences
Andrea Trevisan, Paola Mason, Annamaria Nicolli, Stefano Maso, Marco Fonzo, Bruno Scarpa, Chiara Bertoncello
Summary: The study found that the age and sex of individuals receiving hepatitis B vaccination are significant factors affecting immune response. Additionally, the antibody titers vary depending on the time of vaccination, with females showing higher antibody levels when vaccinated after the age of one.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Chiara Bertoncello, Annamaria Nicolli, Stefano Maso, Marco Fonzo, Mariaangiola Crivellaro, Paola Mason, Andrea Trevisan
Summary: The study found high vaccine uptake among most medical students, especially younger students for vaccines against pertussis, rubella, mumps, and measles, while low coverage rates were observed for varicella, pneumococcus, and meningococcus B vaccines.
Review
Medicine, General & Internal
Elena Di Pierro, Michele De Canio, Rosa Mercadante, Maria Savino, Francesca Granata, Dario Tavazzi, Anna Maria Nicolli, Andrea Trevisan, Stefano Marchini, Silvia Fustinoni
Summary: Porphyrias are a group of clinically and genetically heterogeneous diseases originating mostly from inherited dysfunctions of specific enzymes involved in heme biosynthesis. Laboratory diagnosis can support clinical suspicion in symptomatic patients, and enzymatic activities measurement along with molecular analysis may confirm the diagnosis.
Article
Public, Environmental & Occupational Health
Andrea Trevisan, Paola Mason, Annamaria Nicolli, Stefano Maso, Chiara Bertoncello
Summary: The study found that among future healthcare workers, vaccination compliance was high with high levels of antibody positivity and titer. Variables affecting antibody titer included year of birth and sex, with females showing a more significant antibody response post-vaccination. Recommendations include considering vaccination timing and strategies.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Marco Fonzo, Annamaria Nicolli, Stefano Maso, Lorenzo Carrer, Andrea Trevisan, Chiara Bertoncello
Summary: This study investigated the relationship between overweight/obesity and antibody persistence after vaccination against measles, mumps, rubella (MMR), and hepatitis B virus (HBV). The results showed that there was no significant association between lack of serologic protection and BMI for both HBV vaccine and each component of the MMR vaccine.
Article
Immunology
Marco Fonzo, Chiara Bertoncello, Andrea Trevisan
Summary: This study aimed to assess long-term protection 10-20 years after primary HBV vaccination and investigate the effects of age at first dose, sex, and time between doses. The results showed that early vaccination had a better long-term protective effect, while the impact on vaccination in adolescence was not significant.
Article
Immunology
Paola Mason, Rosario Rizzuto, Luca Iannelli, Flavio Baccaglini, Valerio Rizzolo, Andrea Baraldo, Barbara Melloni, Francesca Maffione, Camilla Pezzoli, Maria Laura Chiozza, Giampietro Rupolo, Marco Biasioli, Filippo Liviero, Maria Luisa Scapellato, Andrea Trevisan, Stefano Merigliano, Alberto Scuttari, Angelo Moretto, Bruno Scarpa
Summary: This study investigated the adverse effects of two SARS-CoV-2 vaccines in a real-life preventive setting at the University of Padova in Italy. It was found that the ChAdOx1 nCoV-19 vaccine caused more adverse effects after the first dose, while the BNT162b2 vaccine caused more adverse effects after the second dose.
Article
Medicine, General & Internal
Annamaria Nicolli, Isabella Bortoletti, Stefano Maso, Andrea Trevisan
Summary: The study assessed the changes of cobalt and chromium in blood and urine after revision surgery from metal-on-metal to ceramic-on-polyethylene total hip arthroplasty. Metal ions levels decreased significantly after revision, with cobalt levels near reference values and chromium levels reaching only 25% of pre-revision levels. While the revision led to a dramatic decrease in metal ions, it did not fully restore chromium levels.
MEDICINA-LITHUANIA
(2021)
Article
Dermatology
Paolo Ventura, Valentina Brancaleoni, Elena Di Pierro, Giovanna Graziadei, Annelise Macri, Claudio Carmine Guida, Annamaria Nicolli, Maria Teresa Rossi, Francesca Granata, Valeria. Fiorentino, Silvia Fustinoni, Raffella Sala, Piergiacomo Calzavara Pinton, Andrea Trevisan, Stefano Marchini, Chiara Cuoghi, Matteo Marcacci, Elena Corradini, Fiammetta Sorge, Caterina Aurizi, Maria Grazia Savino, Maria Domenica Cappellini, Antonello Pietrangelo
EUROPEAN JOURNAL OF DERMATOLOGY
(2020)
