Review
Immunology
Giulia Perego, Giacomo Pietro Vigezzi, Giulia Cocciolo, Federica Chiappa, Stefano Salvati, Federica Balzarini, Anna Odone, Carlo Signorelli, Vincenza Gianfredi
Summary: This study conducted a systematic review and meta-analysis on the efficacy and safety of spray live attenuated influenza vaccine (LAIV), finding that LAIV was associated with a higher probability of seroconversion for the A/H1N1 serotype, and had no significant association with systemic adverse events, with only rhinorrhea, nasal congestion, and sore throat being significantly associated with LAIV compared to the placebo.
Article
Immunology
Wen-Chun Liu, Raffael Nachbagauer, Daniel Stadlbauer, Shirin Strohmeier, Alicia Solorzano, Francesco Berlanda-Scorza, Bruce L. Innis, Adolfo Garcia-Sastre, Peter Palese, Florian Krammer, Randy A. Albrecht
Summary: The study demonstrated that sequential immunization with cHA-based vaccines induced durable antibody responses and provided better protection against the 2009 influenza A virus HA conserved stalk domain in ferrets.
Review
Immunology
Yo Han Jang, Baik L. Seong
Summary: Influenza virus infection poses a major public health challenge, with current vaccines potentially compromised by viral antigenic changes. Efforts are underway to develop a universal influenza vaccine that provides long-lasting and broad protection. Immune responses induced by live attenuated influenza vaccines (LAIVs), including neutralizing antibodies, T cell responses, and mucosal immunity, show promising potential for serving as attractive platforms for a universal influenza vaccine.
Article
Multidisciplinary Sciences
Bo Ryoung Park, Ki-Hye Kim, Tatiana Kotomina, Min-Chul Kim, Young-Man Kwon, Subbiah Jeeva, Yu-Jin Jung, Noopur Bhatnagar, Irina Isakova-Sivak, Daria Mezhenskaya, Larisa Rudenko, Bao-Zhong Wang, Sang-Moo Kang
Summary: A new recombinant influenza virus was developed in this study, showing efficacy in inducing immune responses in mice against different influenza virus subtypes through specific IgG antibody and T cell responses to M2e.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Audrey Lee, Madeleine K. D. Scott, Florian Wimmers, Prabhu S. Arunachalam, Wei Luo, Christopher B. Fox, Mark Tomai, Purvesh Khatri, Bali Pulendran
Summary: This study provides a comprehensive characterization of the transcriptomics and epigenomics of innate populations in the draining lymph nodes after vaccination. The TLR7/8 agonist 3M-052-Alum/OVA induces a robust antiviral and interferon gene program, similar to the yellow fever vaccine, which confers long-lasting protection. Understanding the innate mechanisms of adjuvants and improving vaccine design are critical goals in vaccinology.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
James E. Galen, Rezwanul Wahid, Amanda D. Buskirk
Summary: The use of live-attenuated bacterial vaccines as carriers for mucosal delivery of foreign antigens has been studied for over three decades, but has shown limited success in inducing robust foreign antigen-specific immunity. Research aims to deconstruct bacterial immunity in the human gut to improve carrier vaccine design and enhance immune responses.
Article
Pediatrics
Andrew G. Sokolow, Amy P. Stallings, Carolyn Kercsmar, Theresa Harrington, Natalia Jimenez-Truque, Yuwei Zhu, Katherine Sokolow, M. Anthony Moody, Elizabeth P. Schlaudecker, Emmanuel B. Walter, Mary Allen Staat, Karen R. Broder, C. Buddy Creech
Summary: This study found that among children with asthma aged 5 to 17 years, LAIV4 was not associated with an increased frequency of asthma exacerbations or asthma-related symptoms compared to IIV4. There were no significant differences in asthma symptoms or lung function changes within 14 days post-vaccination between the two groups.
Article
Veterinary Sciences
Kuandyk Zhugunissov, Sanat Kilibayev, Muratbay Mambetaliyev, Kunsulu Zakarya, Markhabat Kassenov, Yergaliy Abduraimov, Yerbol Bulatov, Moldir Azanbekova, Zharkinay Absatova, Khairulla Abeuov, Ryspek Nurgaziev, Gourapura J. Renukaradhya, Kairat Tabynov
Summary: The study developed a live attenuated camelpox virus vaccine and demonstrated its safety and effectiveness in camels. The vaccine showed good immunogenicity and protective efficacy in camels, making it suitable for use under field conditions.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Leyi Lin, Michael A. Koren, Kristopher M. Paolino, Kenneth H. Eckels, Rafael De La Barrera, Heather Friberg, Jeffrey R. Currier, Gregory D. Gromowski, Naomi E. Aronson, Paul B. Keiser, Marvin J. Sklar, Erica L. Sondergaard, Louis E. Jasper, Timothy P. Endy, Richard G. Jarman, Stephen J. Thomas
Summary: The study demonstrates that the heterologous prime-boost vaccination strategy can induce higher levels of immune response and may be superior to homologous strategies in maintaining durable tetravalent immunity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Lorena Sanchez-Felipe, Thomas Vercruysse, Sapna Sharma, Ji Ma, Viktor Lemmens, Dominique Van Looveren, Mahadesh Prasad Arkalagud Javarappa, Robbert Boudewijns, Bert Malengier-Devlies, Laurens Liesenborghs, Suzanne J. F. Kaptein, Carolien De Keyzer, Lindsey Bervoets, Sarah Debaveye, Madina Rasulova, Laura Seldeslachts, Li-Hsin Li, Sander Jansen, Michael Bright Yakass, Babs E. Verstrepen, Kinga P. Boszormenyi, Gwendoline Kiemenyi-Kayere, Nikki van Driel, Osbourne Quaye, Xin Zhang, Sebastiaan ter Horst, Niraj Mishra, Ward Deboutte, Jelle Matthijnssens, Lotte Coelmont, Corinne Vandermeulen, Elisabeth Heylen, Valentijn Vergote, Dominique Schols, Zhongde Wang, Willy Bogers, Thijs Kuiken, Ernst Verschoor, Christopher Cawthorne, Koen Van Laere, Ghislain Opdenakker, Greetje Vande Velde, Birgit Weynand, Dirk E. Teuwen, Patrick Matthys, Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier
Summary: The candidate vaccine YF-S0, utilizing the YF17D vaccine as a vector to express noncleavable prefusion form of the SARS-CoV-2 spike antigen, showed excellent safety, immunogenicity, and efficacy in animal models. It induced high levels of neutralizing antibodies, provided protective immunity against SARS-CoV-2, and prevented infection in hamsters and macaques. A single dose was able to confer protection from lung disease in most vaccinated hamsters within 10 days, highlighting the potential of YF-S0 as a potent SARS-CoV-2 vaccine candidate.
Article
Health Care Sciences & Services
Jessica R. Cataldi, Laura P. Hurley, Megan C. Lindley, Sean T. O'Leary, Carol Gorman, Michaela Brtnikova, Brenda L. Beaty, Lori A. Crane, David K. Shay, Allison Kempe
Summary: The study examined family physicians' and general internal medicine physicians' perceptions, knowledge, and practices regarding high-dose inactivated influenza vaccine (HD-IIV) and live attenuated influenza vaccine (LAIV). Many physicians believed HD-IIV is more effective for patients >= 65 years, and there was a misconception that ACIP had preferential recommendations for HD-IIV.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Virology
Joao P. P. L. Bonifacio, Nathalia Williams, Laure Garnier, Stephanie Hugues, Mirco Schmolke, Beryl Mazel-Sanchez
Summary: This study proposes a safer live attenuated influenza vaccine (optiLAIV) by modifying a nonstructural protein of the currently licensed LAIV. The results show that optiLAIV exhibits better efficacy in both mouse models and a human nasal mucosal model compared to the existing LAIV. This research is important for expanding the application of live attenuated vaccines and reducing the burden of influenza in high-risk populations.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Termpong Dumrisilp, Jongkonnee Wongpiyabovorn, Supranee Buranapraditkun, Chomchanat Tubjaroen, Nataruks Chaijitraruch, Sittichoke Prachuapthunyachart, Palittiya Sintusek, Voranush Chongsrisawat
Summary: This study evaluated the effect of overweight and obesity on the response to live attenuated hepatitis A virus (HAV) vaccine in children and young adults. The results demonstrated that obesity did not significantly impact vaccine response, with females and subjects with truncal obesity showing higher antibody titers post-vaccination.
Article
Cell Biology
Jakob Trimpert, Kristina Dietert, Theresa C. Firsching, Nadine Ebert, Tran Thi Nhu Thao, Daria Vladimirova, Susanne Kaufer, Fabien Labroussaa, Azza Abdelgawad, Andele Conradie, Thomas Hofler, Julia M. Adler, Luca D. Bertzbach, Joerg Jores, Achim D. Gruber, Volker Thiel, Nikolaus Osterrieder, Dusan Kunec
Summary: This study constructed a series of live attenuated vaccine candidates through large-scale recoding of the SARS-CoV-2 genome, evaluating their safety and efficacy in Syrian hamsters. Two tested viruses were found to be highly immunogenic and induced strong protective immunity without causing clinical symptoms in the animals, showing potential as vaccines to combat the ongoing pandemic.
Review
Immunology
Subhan Ullah, Ted M. Ross
Summary: Influenza virus is a major cause of seasonal epidemics and intermittent pandemics. Despite the current molecular biology and vaccine development, influenza virus infection is a significant burden. Vaccines are considered an essential countermeasure for effective control and prevention of influenza virus infection.
EXPERT REVIEW OF VACCINES
(2022)