Article
Immunology
Hector F. Africano, Cristian C. Serrano-Mayorga, Paula C. Ramirez-Valbuena, Ingrid G. Bustos, Alirio Bastidas, Hernan A. Vargas, Sandra Gomez, Alejandro Rodriguez, Carlos J. Orihuela, Luis F. Reyes
Summary: This study found that MACE are common during IPD, with serotypes 3 and 9n independently associated with MACE, regardless of their frequency. Bacteremia occurred in a high percentage of patients with MACE, and MACE patients had significantly elevated serum concentrations of C-reactive protein compared to non-MACE patients.
CLINICAL INFECTIOUS DISEASES
(2021)
Letter
Infectious Diseases
Paulo Camargos, Eliane Drumond, Cristiana M. Nascimento-Carvalho
Summary: The reduction in pneumococcal meningitis was not solely attributed to PCV implementation, but may also be influenced by various factors such as socioeconomic and healthcare improvements. Furthermore, the uncertainty in diagnosing the etiology of meningitis may limit the assessment of missed cases of pneumococcal meningitis, hindering the evaluation of PCV efficacy.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Fernanda Gross Duarte, Maria Goreth Barberino, Sandra da Silva Moreira, Joice Neves Reis, Julia Regazzini Spinardi, Rodrigo Sini de Almeida, Kristen E. Allen, Ronika Alexander-Parrish, Rosa Brim, Cesar Augusto de Araujo Neto, Edson Duarte Moreira
Summary: There is a high burden of pneumococcal community-acquired pneumonia (CAP) among adults in Brazil, despite routine immunization. Vaccine serotypes of pneumococcal CAP continue to be a persistent problem in this population.
Article
Immunology
Andrew Anglemyer, Andrea McNeill, Kara DuBray, Gerard J. B. Sonder, Tony Walls
Summary: New Zealand's shift from PCV13 to PCV10 has led to an increasing number of serotype 19A cases in young children and a rise in penicillin-resistant isolates. It is necessary for NZ to reconsider its choice of pneumococcal vaccine.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Tianyan Hu, Yan Song, Nicolae Done, Qing Liu, Eric M. Sarpong, Esteban Lemus-Wirtz, James Signorovitch, Salini Mohanty, Thomas Weiss
Summary: This study estimated the annual incidence rates and time trends of invasive pneumococcal disease (IPD) in US children before and after the introduction of pneumococcal conjugate vaccines (PCVs). The results showed a gradual decline in IPD incidence rates from 1998 to 2018, with larger declines during the early PCV7 and PCV13 periods and among younger children. However, the residual burden of IPD remains substantial.
Letter
Immunology
Bin Chang, Masatomo Morita, Akiyoshi Nariai, Kei Kasahara, Akira Kakutani, Michinaga Ogawa, Makoto Ohnishi, Kazunori Oishi
Summary: We report two adult cases of invasive disease caused by Streptococcus oralis expressing serotype 3 pneumococcal capsule and forming mucoid colonies. Whole-genome sequencing revealed that the identical serotype 3 pneumococcal capsule locus and hyl fragment were recombined into the genomes of two distinct S. oralis strains.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Rameela Raman, Julia Brennan, Danielle Ndi, Chantel Sloan, Tiffanie M. Markus, William Schaffner, H. Keipp Talbot
Summary: The introduction of PCV13 was found to be associated with substantial reductions in overall incidence and socioeconomic and racial disparities in PCV13-serotype incidence.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Maria Deloria Knoll, Julia C. Bennett, Maria Garcia Quesada, Eunice W. Kagucia, Meagan E. Peterson, Daniel R. Feikin, Adam L. Cohen, Marissa K. Hetrich, Yangyupei Yang, Jenna N. Sinkevitch, Krow Ampofo, Laurie Aukes, Sabrina Bacci, Godfrey Bigogo, Maria-Cristina C. Brandileone, Michael G. Bruce, Romina Camilli, Jesus Castilla, Guanhao Chan, Grettel Chanto Chacon, Pilar Ciruela, Heather Cook, Mary Corcoran, Ron Dagan, Kostas Danis, Sara de Miguel, Philippe De Wals, Stefanie Desmet, Yvonne Galloway, Theano Georgakopoulou, Laura L. Hammitt, Markus Hilty, Pak-Leung Ho, Sanjay Jayasinghe, James D. Kellner, Jackie Kleynhans, Mirjam J. Knot, Jana Kozakova, Karl Gustaf Kristinsson, Shamez N. Ladhani, Claudia S. Lara, Maria Eugenia Leon, Tiia Lepp, Grant A. Mackenzie, Lucia Mad'arova, Allison McGeer, Tuya Mungun, Jason M. Mwenda, J. Pekka Nuorti, Nehemie Nzoyikorera, Lucia Helena De Oliveira, Metka Paragi, Tamara Pilishvili, Rodrigo Puentes, Eric Rafai, Samir K. Saha, Larisa Savrasova, Camelia Savulescu, J. Anthony Scott, Kevin J. Scott, Fatima Serhan, Lena Petrova Setchanova, Nadja Sinkovec Zorko, Anna Skoczynska, Todd D. Swarthout, Palle Valentiner-Branth, Mark van Der Linden, Didrik E. Vestrheim, Anne von Gottberg, Inci Yildirim, Kyla Hayford
Summary: This study provides a comprehensive overview of serotype-specific IPD surveillance in countries using PCV10/13, with a focus on the PSERENADE project. The analysis includes data from multiple sites across geographic regions and different vaccination schedules, aiming to estimate the impact of PCV and inform decision-making at national and global levels.
Article
Immunology
Germaine Hanquet, Pavla Krizova, Tina Dalby, Shamez N. Ladhani, J. Pekka Nuorti, Kostas Danis, Jolita Mereckiene, Mirjam J. Knol, Brita A. Winje, Pilar Ciruela, Sara de Miguel, Maria Eugenia Portillo, Laura MacDonald, Eva Morfeldt, Jana Kozakova, Palle Valentiner-Branth, Norman K. Fry, Hanna Rinta-Kokko, Emmanuelle Varon, Mary Corcoran, Arie van der Ende, Didrik F. Vestrheim, Carmen Munoz-Almagro, Juan-Carlos Sanz, Jesus Castilla, Andrew Smith, Birgitta Henriques-Normark, Edoardo Colzani, Lucia Pastore-Celentano, Camelia Savulescu
Summary: We evaluated the incidence of invasive pneumococcal disease (IPD) in Europe during the 8 years of infant pneumococcal conjugate vaccine (PCV) programs using PCV10 and PCV13 vaccines. IPD incidence declined between 2011 and 2014, but increased between 2015 and 2018. The incidence of non-PCV13 serotypes increased while PCV13 serotypes decreased. Similar trends were observed in countries using PCV13 or PCV10 vaccines. The study highlights the need for new vaccines providing broader serotype protection.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Ron Dagan, Shalom Ben-Shimol, Rachel Benisty, Gili Regev-Yochay, Stephanie W. Lo, Stephen D. Bentley, Paulina A. Hawkins, Lesley McGee, Merav Ron, Noga Givon-Lavi, Lea Valinsky, Assaf Rokney
Summary: In Israel during the PCV13 era, an outbreak of Sp2 IPD caused by the emerging ST-13578 clone was identified. This clone, mainly found in the Jewish population and specific regions of Israel, showed clonality and likely evolved from ST-1504 through recombination processes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Reema Subramanian, Veranja Liyanapathirana, Nilakshi Barua, Rui Sun, Maggie Haitian Wang, Rita Ng, Edmund A. S. Nelson, David S. Hui, Margaret Ip
Summary: The epidemiology of hospitalised pneumococcal disease in adults was assessed following the introduction of universal childhood pneumococcal immunisation in 2009. It was found that invasive pneumococcal disease and pneumonia cases existed, with serotype 19F being replaced by serotype 3 over time.
Article
Immunology
Marta Bertran, Zahin Amin-Chowdhury, Carmen L. Sheppard, Seyi Eletu, Dania Zamarreno, Mary E. Ramsay, David Litt, Norman K. Fry, Shamez N. Ladhani
Summary: In England, after the removal of COVID-19 restrictions in July-December 2021, the incidence of invasive pneumococcal disease in children under 15 years old was higher compared to the same period in 2020 and the pre-pandemic years of 2017-2019. This highlights the potential risk following the relaxation of COVID-19 restrictions, emphasizing the need to maintain childhood vaccine coverage to protect the population.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Muhammad Imran Nisar, Fyezah Jehan, Shahira Shahid, Sheraz Ahmed, Sadia Shakoor, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Farah Khalid, Sajid Muhammad, Benjamin M. Althouse, Hao Hu, Cynthia G. Whitney, Asad Ali, Anita K. M. Zaidi, Saad B. Omer, Najeeha Iqbal
Summary: Pakistan introduced the PCV10 vaccine in 2013 and conducted a study on infants from 2014-2018. The study showed a significant decrease in carriage of vaccine-related serotypes and an increase in non-vaccine related serotypes. This highlights the need for continuous monitoring and evaluation of existing vaccine formulations.
Article
Immunology
Genevieve Deceuninck, Nicholas Brousseau, Brigitte Lefebvre, Caroline Quach, Bruce Tapiero, Yen-Giang Bui, Michael Desjardins, Philippe De Wals
Summary: In the province of Quebec, Canada, a 2 + 1 dose pneumococcal conjugate vaccine (PCV) program for children was implemented, with varying vaccine replacements. PCV13 showed 88% effectiveness against serotype 3 invasive pneumococcal disease after the first dose, but no protection was observed thereafter, and there was no trend of increased effectiveness with the number of doses.
Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Respiratory System
A. Vila-Corcoles, O. Ochoa-Gondar, A. Vila-Rovira, M. Aragon, L. Esteban-Julvez, N. Chamorro, I Hospital, E. Satue, J. Blade, C. de Diego, F. Gomez-Bertomeu, X. Raga
Article
Microbiology
Ana Fernandez-Bravo, Isabel Fort-Gallifa, Frederic Ballester, Isabel Pujol, Frederic Gomez-Bertomeu, Mariola Dominguez, Miquel Mico, Eva Alcoceba, Josep Maria Simo-Siso, Maria Jose Figueras
Article
Peripheral Vascular Disease
Angel Vila-Corcoles, Eva Satue-Gracia, Olga Ochoa-Gondar, Cristina Torrente-Fraga, Frederic Gomez-Bertomeu, Angel Vila-Rovira, Imma Hospital-Guardiola, Cinta de Diego-Cabanes, Ferran Bejarano-Romero, Dolors Rovira-Veciana, Josep Basora-Gallisa
JOURNAL OF CLINICAL HYPERTENSION
(2020)
Letter
Infectious Diseases
Ester Parada-Ricart, Frederic Gomez-Bertomeu, Ester Pico-Planac, Montserrat Olona-Cabases
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2021)
Article
Infectious Diseases
Silvia Montolio Breva, Carmen Molina Clavero, Frederic Gomez Bertomeu, Ester Pico-Plana, Nuria Serrat Orus, Inmaculada Palau Sanchez, Maria Teresa Mestre-Prad, Maria Teresa Sans-Mateu
Summary: This study assessed the performance of five immunoassays and one rapid immunochromatographic test for the detection of anti-SARS-CoV-2 antibodies. The tests showed sensitivities around 70-90% and specificities greater than 95%.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Infectious Diseases
Marta Mari-Almirall, Clara Cosgaya, Cristina Pitart, Joaquim Vines, Laura Munoz, Irene Campo, Anna Cusco, Laura Rodriguez-Serna, Gemina Santana, Ana Del Rio, Olga Francino, Pilar Ciruela, Isabel Pujol, Frederic Ballester, Francesc Marco, Jose Antonio Martinez, Alex Soriano, Jordi Vila, Ignasi Roca
Summary: This study identified the inter-hospital dissemination of carbapenem-resistant high-risk clones of Klebsiella pneumoniae and Escherichia coli in Catalonia, Spain. The isolates were found to carry small transferable plasmids containing bla(NDM) genes, with most showing multidrug resistance and NDM production. The main clone belonged to ST147 and co-produced NDM-1 and CTX-M-15, with a few isolates also carrying bla(OXA-48).
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Cristina Lasarte-Monterrubio, Juan C. Vazquez-Ucha, Maria Maneiro, Jorge Arca-Suarez, Isaac Alonso, Paula Guijarro-Sanchez, John D. Buynak, German Bou, Concepcion Gonzalez-Bello, Alejandro Beceiro
Summary: Combining LN-1-255 with imipenem, meropenem, cefepime, and sulbactam shows promising results in reducing resistance rates of Acinetobacter baumannii, especially carbapenem-resistant isolates, demonstrating a potential new strategy for the treatment of infections caused by this pathogen.
Article
Medicine, General & Internal
Eva M. Satue-Gracia, Angel Vila-Corcoles, Cinte De Diego-Cabanes, Angel Vila-Rovira, Cristina Torrente-Fraga, Frederic Gomez-Bertomeu, Imma Hospital-Guardiola, Olga Ochoa-Gondar, Francisco Martin-Lujan
Summary: This study analyzed the susceptibility and risk factors for COVID-19 among middle-aged and older adults. The results showed that increasing age, nursing-home residence, and multiple comorbidities increased the risk of COVID-19, while the use of statins, angiotensin-receptor blockers/inhibitors, and influenza vaccination was associated with a reduced risk.
Article
Infectious Diseases
Raquel Carbonell, Gerard Moreno, Ignacio Martin-Loeches, Frederic Gomez-Bertomeu, Carolina Sarvise, Josep Gomez, Maria Bodi, Emili Diaz, Elisabeth Papiol, Sandra Trefler, Mercedes Nieto, Angel Estella, Maria Jimenez Herrera, Pablo Vidal Cortes, Juan Jose Guardiola, Jordi Sole-Violan, Alejandro Rodriguez
Summary: A study on 1608 patients with severe influenza pneumonia found that patients with bacterial co-infection had significantly higher PCT and CRP levels, and deceased patients had higher PCT levels compared to survivors. However, these biomarkers were not significantly associated with mortality, and they did not have enough discriminatory power to predict the causative microorganism of the co-infection.
Article
Biochemistry & Molecular Biology
Elena Yeregui, Jenifer Masip, Consuelo Vilades, Pere Domingo, Yolanda M. Pacheco, Julia Blanco, Josep Mallolas, Veronica Alba, Montserrat Vargas, Graciano Garcia-Pardo, Eugenia Negredo, Montserrat Olona, Judit Vidal-Gonzalez, Maria Peraire, Anna Marti, Laia Reverte, Frederic Gomez-Bertomeu, Manuel Leal, Francesc Vidal, Joaquim Peraire, Anna Rull
Summary: Low concentrations of adiponectin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) were associated with poor immune recovery in treated PLHIV, indicating potential predictive biomarkers of a discordant immunological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
A. Redin, P. Ciruela, M. F. de Sevilla, F. Gomez-Bertomeu, S. Gonzalez-Peris, M. A. Benitez, G. Trujillo, A. Diaz, E. Jou, C. Izquierdo, M. O. Perez-Moreno, F. Moraga-Llop, M. Olsina, B. Vinado, E. Sanfeliu, A. Garcia, S. Gonzalez-di Lauro, J. J. Garcia-Garcia, A. Dominguez, R. Sa-Leao, C. Munoz-Almagro
Summary: The study revealed that the introduction of the PCV13 vaccine led to a decrease in the number of IPD cases caused by serotypes included in the vaccine across all age groups. However, there was an unexpected increase in the number of IPD cases caused by serotypes not included in the vaccine, especially in the >65-year-old group. Additionally, a significant increase in serotype 3 included in the vaccine was observed, indicating the need for the incorporation of more serotypes in future vaccines and more thorough surveillance of Streptococcus pneumoniae dynamics.
MICROBIOLOGY SPECTRUM
(2021)
Article
Oncology
Laia Reverte, Elena Yeregui, Montserrat Olona, Alicia Gutierrez-Valencia, Maria Jose Buzon, Anna Marti, Frederic Gomez-Bertomeu, Teresa Auguet, Luis F. Lopez-Cortes, Joaquin Burgos, Clara Benavent-Bofill, Carme Boque, Graciano Garcia-Pardo, Ezequiel Ruiz-Mateos, Maria Teresa Mestre, Francesc Vidal, Consuelo Vilades, Joaquim Peraire, Anna Rull
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Jenifer Masip, Norma Rallon, Elena Yeregui, Montserrat Olona, Salvador Resino, Jose M. Benito, Consuelo Vilades, Graciano Garcia-Pardo, Jose Alcami, Ezequiel Ruiz-Mateos, Frederic Gomez-Bertomeu, Montserrat Vargas, Marta Navarro, Jose A. Oteo, Juan A. Pineda, Anna Marti, Veronica Alba, Francesc Vidal, Joaquin Peraire, Anna Rull
Summary: Long-term elite controllers exhibit elevated tricarboxylic acid (TCA) cycle function and alpha-ketoglutaric acid is identified as a key metabolite in persistent control. Conversely, lipidomics analysis suggests that an elevated lipidomics plasma profile could predict the reignition of viral replication in LTEC individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Carles Perpinan, Laia Bertran, Ximena Terra, Carmen Aguilar, Jessica Binetti, Miguel Lopez-Dupla, Anna Rull, Laia Reverte, Elena Yeregui, Frederic Gomez-Bertomeu, Joaquim Peraire, Teresa Auguet
Summary: This study investigates the feasibility of using baseline cytokines as early prognostic biomarkers for COVID-19, and analyzes the impact of comorbidities such as obesity or metabolic syndrome on the cytokine profile. The results reveal that resistin and IL-15 are associated with worse prognosis of COVID-19 and serve as the best early predictors for requiring invasive ventilation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jenifer Masip, Rosa Jorba, Miguel Lopez-Dupla, Pere Domingo, Yolanda Maria Pacheco, Graciano Garcia-Pardo, Esteban Martinez, Consuelo Vilades, Sergi Veloso, Veronica Alba, Montserrat Olona, Francesc Vidal, Frederic Gomez-Bertomeu, Joaquim Peraire, Anna Rull
Summary: Nuclear magnetic resonance (NMR)-based lipoprotein tests have shown that LDL-P and HDL-P are better predictors of cardiovascular risk than traditional cholesterol markers. In people with HIV, impaired immune function may be associated with preclinical atherosclerosis and vascular dysfunction. Starting antiretroviral therapy (ART) can equalize the lipoprotein-based cardiovascular risk markers between individuals with poor immunological response (INR) and good immunological response (IR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)