Article
Immunology
Se Chang Oh, Soo Min Park, Jian Hur, Eun Young Choi, Hyun Jung Jin, Yu Kyung Kim, Jong Ho Lee, Ji Young Ahn, Jae Min Lee
Summary: The study investigated the effectiveness of mPCR for early diagnosis of pertussis, revealing that most patients were diagnosed within two weeks from symptom onset and required hospitalization and antibiotic treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Varistha Phetcharakupt, Ekawat Pasomsub, Sasisopin Kiertiburanakul
Summary: The RIDT has fair sensitivity but high specificity for diagnosing influenza, and factors such as cough, rhinorrhea, and higher body temperature may be predictive for influenza among patients with ILI.
HEALTH SCIENCE REPORTS
(2021)
Article
Infectious Diseases
Victor Au Yeung, Kiran Thapa, William Rawlinson, Andrew Georgiou, Jeffrey J. Post, Kristen Overton
Summary: This study found that the use of RPCR testing in influenza management can improve antibiotic stewardship by reducing antibiotic use and improving oseltamivir initiation in high-risk populations. However, further research is needed to determine other factors that may have influenced hospital length of stay and a cost-benefit analysis should be conducted to determine the financial impact of RPCR testing.
BMC INFECTIOUS DISEASES
(2021)
Article
Ophthalmology
Satoko Nakano, Yasuhiro Tomaru, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Norio Shimizu, Sunao Sugita
Summary: The Direct Strip PCR test offers rapid and accurate detection of infectious pathogens causing uveitis. It shows high concordance with qPCR results, even when used by beginners, indicating its reliability for clinical use. Additionally, it can be used for intraoperative diagnosis, improving the prognosis of infectious diseases.
Article
Chemistry, Analytical
Kunlun Jiang, Jingrui Wu, Yuwei Qiu, Yun Young Go, Kiwon Ban, Hyun June Park, Jung-Hoon Lee
Summary: The PPT-cPCR method is a fast, sensitive, inexpensive, and simple nucleic acid detection technique that allows for visual detection of DNA targets and easy access to quantitative information using a spectrophotometer and a smartphone.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Huina Wu, Mingyuan Zou, Xiaobo Fan, Feiya Su, Feng Xiao, Meiling Zhou, Yan Sun, Fengfeng Zhao, Guoqiu Wu
Summary: A catalytic hairpin assembly (CHA) combined with lateral flow immunoassay (CHA-LFIA) method was proposed for rapid and precise detection of influenza viruses and RSV, demonstrating high sensitivity and specificity.
Article
Immunology
Kailey Hughes, Donald B. Middleton, Mary Patricia Nowalk, Goundappa K. Balasubramani, Emily T. Martin, Manjusha Gaglani, H. Keipp Talbot, Manish M. Patel, Jill M. Ferdinands, Richard K. Zimmerman, Fernanda P. Silveira
Summary: This study evaluated the vaccine effectiveness against influenza hospitalization among immunocompromised adults during the 2017-2018 influenza season. The results showed that while immunocompromised adults had a higher vaccination rate, their protection against influenza was lower, with a vaccine effectiveness of 33% in the overall adult population. Further research is needed to assess vaccine effectiveness among different immunocompromising conditions and explore ways to improve effectiveness for immunocompromised individuals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Wenping Hu, Paul A. Sjoberg, Laurie S. DeMarcus, Anthony S. Robbins
Summary: This study assessed the effectiveness of inactivated influenza vaccine in adults and found that it provided moderate protection against influenza virus infection in multiple seasons. The vaccine showed good effectiveness against influenza A(H1N1)pdm09 and influenza B, but lower effectiveness against influenza A(H3N2).
Article
Chemistry, Analytical
Sakda Jampasa, Chahya Kreangkaiwal, Kurt Kalcher, Wassa Waiwinya, Teerasit Techawiwattanaboon, Nopporn Songumpai, Passorn Sueyanyongsiri, Kampol Pattanasombatsakul, Malee Techapornroong, Saovanee Benjamanukul, Orawon Chailapakul, Kanitha Patarakul, Sudkate Chaiyo
Summary: This study developed a diagnostic device for leptospiral detection that integrates near-field communication and a portable smartphone. The device offers high specificity, selectivity, simplicity, and requires minimal sample volume, making it suitable for countries with limited medical facilities and resources.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Masayoshi Shinjoh, Norio Sugaya, Yoshio Yamaguchi, Ichiro Ookawara, Yuji Nakata, Atsushi Narabayashi, Munehiro Furuichi, Naoko Yoshida, Akinobu Kamei, Yuu Kuramochi, Akimichi Shibata, Motoko Shimoyamada, Hisataka Nakazaki, Naohiko Maejima, Erika Yuasa, Eriko Araki, Naonori Maeda, Takuma Ohnishi, Mitsuhiro Nishida, Nobuhiko Taguchi, Makoto Yoshida, Kenichiro Tsunematsu, Meiwa Shibata, Yasuhiro Hirano, Shinichiro Sekiguchi, Chiharu Kawakami, Keiko Mitamura, Takao Takahashi
Summary: This study evaluated the vaccine effectiveness of inactivated influenza vaccine (IIV) in children during the 2018/19 season in Japan. The results showed a high VE against A(H1N1pdm09) and a low VE against non-A(H1N1pdm09) influenza A, especially H3N2. The effectiveness of IIV against A(H3N2) was low not only in adults but also in children during the 2018/19 season.
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Thais Simoes Camargo, Moacyr Silva Junior, Luis Fernando Aranha Camargo, Veronica Pivetta Biotto, Andre Mario Doi, Paula Celia Mariko Koga, Carolina Nunes Franca, Marines Dalla Valle Martino
Summary: This study compares molecular and rapid diagnostic methods for Clostridioides difficile infection, finding greater sensitivity in PCR-based methods and GDH-based assays. The proposed algorithm has some minor monetary disadvantages but achieves a 10% time optimization.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Chemistry, Analytical
Linlin Zhuang, Jianbo Yang, Chunlei Song, Li Sun, Bin Zhao, Qiuping Shen, Xiyan Ren, Hongjing Shi, Yu Zhang, Mengling Zhu
Summary: An accurate and practical graphene oxide-based method, called GO-ASEA, was developed for rapid and highly sensitive detection of African swine fever virus (ASFV). This novel assay showed excellent specificity and selectivity, with a low detection limit, and demonstrated good clinical applicability. The GO-ASEA method has the potential to serve as a robust tool in epidemic prevention and point-of-care diagnosis.
ANALYTICAL METHODS
(2022)
Article
Immunology
Shekhar Ghamande, Courtney Shaver, Kempapura Murthy, Chandni Raiyani, Heath D. White, Tasnim Lat, Alejandro C. Arroliga, Dayna Wyatt, H. Keipp Talbot, Emily T. Martin, Arnold S. Monto, Richard K. Zimmerman, Donald B. Middleton, Fernanda P. Silveira, Jill M. Ferdinands, Manish M. Patel, Manjusha Gaglani
Summary: The study found that the vaccine effectiveness against adult acute respiratory illness hospitalization for radiographically identified laboratory confirmed influenza-associated pneumonia was 38% during the 2015-2016 to 2017-2018 seasons in the US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN). The effectiveness was highest against influenza A (H1N1)pdm09 and lowest against influenza B.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Mark W. Tenforde, Rebecca J. Garten Kondor, Jessie R. Chung, Richard K. Zimmerman, Mary Patricia Nowalk, Michael L. Jackson, Lisa A. Jackson, Arnold S. Monto, Emily T. Martin, Edward A. Belongia, Huong Q. McLean, Manjusha Gaglani, Arundhati Rao, Sara S. Kim, Thomas J. Stark, John R. Barnes, David E. Wentworth, Manish M. Patel, Brendan Flannery
Summary: This study investigated the vaccine effectiveness against emerging influenza viruses during the 2019-2020 season in the United States. The results showed that the vaccine provided good protection against B/Victoria viruses, but lower effectiveness against A(H1N1)pdm09 viruses, mainly due to vaccine mismatch caused by antigenic drift. The study observed the impact of antigenic drift on vaccine protection, with significant protection still observed even in drifted years.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Miranda J. Delahoy, Flor Munoz, De-Kun Li, Carmen Sofia Arriola, Nanette Lee Bond, Michael Daugherty, Jeannette Ferber, Nickolas Ferguson, Louise Hadden, Jillian T. Henderson, Stephanie A. Irving, Mary Juergens, Venkatesh Kancharla, Mara Greenberg, Roxana Odouli, Gabriella Newes-Adeyi, Erin G. Nicholson, Lawrence Reichle, Momodou Sanyang, Margaret Snead, Fatimah S. Dawood, Allison L. Naleway
Summary: This study analyzed electronic health record data from pregnant individuals at three healthcare networks in the US to investigate SARS-CoV-2 testing practices during peripartum hospitalizations. The findings revealed potential disparities in testing based on demographic and pregnancy characteristics, highlighting the need for equitable testing practices and care for pregnant individuals with SARS-CoV-2 infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Infectious Diseases
Stephanie A. Irving, Nicola P. Klein
LANCET INFECTIOUS DISEASES
(2023)
Article
Immunology
Malini B. DeSilva, Patrick K. Mitchell, Nicola P. Klein, Brian E. Dixon, Mark W. Tenforde, Mark G. Thompson, Allison L. Naleway, Shaun J. Grannis, Toan C. Ong, Karthik Natarajan, Sarah E. Reese, Ousseny Zerbo, Anupam B. Kharbanda, Palak Patel, Edward Stenehjem, Chandni Raiyani, Stephanie A. Irving, William F. Fadel, Suchitra Rao, Jungmi Han, Sue Reynolds, Jonathan M. Davis, Ned Lewis, Charlene McEvoy, Monica Dickerson, Kristin Dascomb, Nimish R. Valvi, Michelle A. Barron, Kristin Goddard, Gabriela Vazquez-Benitez, Nancy Grisel, Mufaddal Mamawala, Peter J. Embi, Bruce Fireman, Inih J. Essien, Eric P. Griggs, Julie Arndorfer, Manjusha Gaglani
Summary: This study assessed the impact of COVID-19 vaccination on illness severity among hospitalized adults with COVID-19. The findings showed that vaccination with 2 or 3 mRNA vaccine doses was associated with reduced ICU admission and in-hospital death, as well as shorter hospital stays.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Mark W. Tenforde, Zachary A. Weber, Malini B. DeSilva, Edward Stenehjem, Duck-Hye Yang, Bruce Fireman, Manjusha Gaglani, Noah Kojima, Stephanie A. Irving, Suchitra Rao, Shaun J. Grannis, Allison L. Naleway, Lindsey Kirshner, Anupam B. Kharbanda, Kristin Dascomb, Ned Lewis, Alexandra F. Dalton, Sarah W. Ball, Karthik Natarajan, Toan C. Ong, Emily Hartmann, Peter J. Embi, Charlene E. McEvoy, Nancy Grisel, Ousseny Zerbo, Margaret M. Dunne, Julie Arndorfer, Kristin Goddard, Monica Dickerson, Palak Patel, Julius Timbol, Eric P. Griggs, John Hansen, Mark G. Thompson, Brendan Flannery, Nicola P. Klein
Summary: During the 2021-2022 United States influenza season with predominant influenza A(H3N2) virus circulation, vaccine effectiveness against influenza-associated emergency department/urgent care encounters and hospitalizations were both 25%, with effectiveness varying by age group and presence of immunocompromising conditions.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Editorial Material
Infectious Diseases
Stephanie A. Irving, Sarah A. Buchan
LANCET INFECTIOUS DISEASES
(2023)
Article
Immunology
Isabel Griffin, Stephanie A. Irving, Carmen Sofia Arriola, Angela P. Campbell, De-Kun Li, Fatimah S. Dawood, Caroline Doughty-Skierski, Jeannette R. Ferber, Nickolas Ferguson, Louise Hadden, Jillian T. Henderson, Mary Juergens, Venkatesh Kancharla, Allison L. Naleway, Gabriella Newes-Adeyi, Erin Nicholson, Roxana Odouli, Lawrence Reichle, Mo Sanyang, Kate Woodworth, Flor M. Munoz
Summary: This study examined the incidence and risk factors of COVID-19 among infants under 6 months of age. The results showed that 1.0% of infants whose mothers received prenatal care had medically attended COVID-19 episodes. Infants born to women with postpartum COVID-19 had a higher risk, highlighting the importance of COVID-19 prevention measures for the household members and caregivers of infants.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Nicola P. Klein, Maria Demarco, Katherine E. Fleming-Dutra, Melissa S. Stockwell, Anupam B. Kharbanda, Manjusha Gaglani, Suchitra Rao, Ned Lewis, Stephanie A. Irving, Emily Hartmann, Karthik Natarajan, Alexandra F. Dalton, Ousseny Zerbo, Malini B. DeSilva, Deepika Konatham, Edward Stenehjem, Elizabeth A. K. Rowley, Toan C. Ong, Shaun J. Grannis, Chantel Sloan-Aagard, Jungmi Han, Jennifer R. Verani, Chandni Raiyani, Kristin Dascomb, Sarah E. Reese, Michelle A. Barron, William F. Fadel, Allison L. Naleway, Juan Nanez, Monica Dickerson, Kristin Goddard, Kempapura Murthy, Nancy Grisel, Zacharay A. Weber, Brian E. Dixon, Palak Patel, Bruce Fireman, Julie Arndorfer, Nimish R. Valvi, Eric P. Griggs, Carly Hallowell, Peter J. Embi, Sarah W. Ball, Mark G. Thompson, Mark W. Tenforde, Ruth Link-Gelles
Summary: This study assessed the effectiveness of the BNT162b2 vaccine against mild to moderate and severe COVID-19 in children and adolescents during the Omicron BA.4/BA.5 period. The results showed that the vaccine had high effectiveness during the Delta period, but the effectiveness decreased during the Omicron period. A monovalent booster increased the effectiveness. Vaccination was recommended for children and adolescents.
Article
Immunology
Tat'Yana A. Kenigsberg, Kayla E. Hanson, Nicola P. Klein, Ousseny Zerbo, Kristin Goddard, Stanley Xu, W. Katherine Yih, Stephanie A. Irving, Laura P. Hurley, Jason M. Glanz, Robyn Kaiser, Lisa A. Jackson, Eric S. Weintraub
Summary: This study investigated the safety of simultaneous vaccination (SV) with COVID-19 vaccines and other vaccines. The results showed that there were no significant differences in health outcomes between COVID-19 vaccine recipients who received SV and those who did not. Some individual outcomes had statistically significant rate ratios, but the number of outcomes was small and there was no adjustment for multiple testing.
Article
Immunology
Peter J. Embi, Matthew E. Levy, Palak Patel, Malini B. Desilva, Manjusha Gaglani, Kristin Dascomb, Margaret M. Dunne, Nicola P. Klein, Toan C. Ong, Shaun J. Grannis, Karthik Natarajan, Duck-Hye Yang, Edward Stenehjem, Ousseny Zerbo, Charlene Mcevoy, Suchitra Rao, Mark G. Thompson, Deepika Konatham, Stephanie A. Irving, Brian E. Dixon, Jungmi Han, Kristin E. Schrader, Nancy Grisel, Ned Lewis, Anupam B. Kharbanda, Michelle A. Barron, Sue Reynolds, I-Chia Liao, William F. Fadel, Elizabeth A. Rowley, Julie Arndorfer, Kristin Goddard, Kempapura Murthy, Nimish R. Valvi, Zachary A. Weber, Bruce Fireman, Sarah E. Reese, Sarah W. Ball, Allison L. Naleway
Summary: Immunocompromised (IC) adults have a higher risk of severe COVID-19 outcomes and are less protected by 1-2 vaccine doses compared to non-IC adults. The study found that the vaccine effectiveness against medically attended COVID-19 was lower in IC adults, especially among transplant recipients.
Article
Immunology
Alexandra F. Dalton, Alexia Couture, Malini B. DeSilva, Stephanie A. Irving, Shruti Gohil, Suchitra Rao, Rebecca Fink, Allison L. Naleway, Zijing Guo, Devi Sundaresan, Rebecca J. Birch, Sarah Ball, Kai Zheng, Toan C. Ong, Carrie Reed, Catherine H. Bozio
Summary: Limited data on influenza testing among adults with acute respiratory illness (ARI)-associated hospitalizations were examined. The study identified important factors associated with influenza testing, such as ARI diagnoses, indicators of influenza activity, and hospital admission month.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Surgery
Ruth Link-Gelles, Zachary A. Weber, Sarah E. Reese, Amanda B. Payne, Manjusha Gaglani, Katherine Adams, Anupam B. Kharbanda, Karthik Natarajan, Malini B. DeSilva, Kristin Dascomb, Stephanie A. Irving, Nicola P. Klein, Shaun J. Grannis, Toan C. Ong, Peter J. Embi, Margaret M. Dunne, Monica Dickerson, Charlene McEvoy, Julie Arndorfer, Allison L. Naleway, Kristin Goddard, Brian E. Dixon, Eric P. Griggs, John Hansen, Nimish Valvi, Morgan Najdowski, Julius Timbol, Colin Rogerson, Bruce Fireman, William F. Fadel, Palak Patel, Caitlin S. Ray, Ryan Wiegand, Sarah Ball, Mark W. Tenforde
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Obstetrics & Gynecology
Stephanie A. Irving, Bradley Crane, Eric Weintraub, Tia L. Kauffman, Neon Brooks, Suchita A. Patel, Hilda Razzaghi, Edward A. Belongia, Matthew F. Daley, Darios Getahun, Sungching C. Glenn, Simon J. Hambidge, Lisa A. Jackson, Elyse Kharbanda, Nicola P. Klein, Ousseny Zerbo, Allison L. Naleway
Summary: Limited data on influenza vaccination coverage among pregnant people in the United States during the COVID-19 pandemic show an increase in annual coverage from the 2016-2017 season to the 2019-2020 season, followed by a decrease in coverage during the COVID-19 pandemic. Coverage was lowest among pregnant people aged 18-24 years and non-Hispanic Black pregnant people. The recent decreases emphasize the need for ongoing efforts to improve vaccination coverage among pregnant people.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Immunology
Tat 'Yana A. Kenigsberg, Kristin Goddard, Kayla E. Hanson, Ned Lewis, Nicola Klein, Stephanie A. Irving, Allison L. Naleway, Bradley Crane, Tia L. Kauffman, Stanley Xu, Matthew F. Daley, Laura P. Hurley, Robyn Kaiser, Lisa A. Jackson, Amelia Jazwa, Eric S. Weintraub
Summary: The US FDA authorized the use of mRNA COVID-19 bivalent booster vaccines, and CDC's clinical guidance allows for simultaneous administration of COVID-19 and other vaccines. A study found that 32.1% of individuals who received a COVID-19 bivalent booster vaccine also received a simultaneous influenza vaccine, which may impact the delivery of immunization services.
Article
Immunology
Stephanie A. Irving, Holly C. Groom, Edward A. Belongia, Bradley Crane, Matthew F. Daley, Kristin Goddard, Lisa A. Jackson, Tia L. Kauffman, Tat'Yana A. Kenigsberg, Leslie Kuckler, Allison L. Naleway, Suchita A. Patel, Hung Fu Tseng, Josh T. B. Williams, Eric S. Weintraub
Summary: In the United States, influenza vaccination coverage increased from 2017-18 to 2019-20, then decreased to the lowest level in the 2022-23 season. The lowest coverage was observed among males, individuals aged 18-49, non-Hispanic Black people, and those without high-risk conditions.
Article
Public, Environmental & Occupational Health
Ruth Link-Gelles, Allison Avrich Ciesla, Elizabeth A. K. Rowley, Nicola P. Klein, Allison L. Naleway, Amanda B. Payne, Anupam Kharbanda, Karthik Natarajan, Malini B. DeSilva, Kristin Dascomb, Stephanie A. Irving, Ousseny Zerbo, Sarah E. Reese, Ryan E. Wiegand, Morgan Najdowski, Toan C. Ong, Suchitra Rao, Melissa S. Stockwell, Ashley Stephens, Kristin Goddard, Yessica C. Martinez, Zachary A. Weber, Bruce Fireman, John Hansen, Julius Timbol, Shaun J. Grannis, Michelle A. Barron, Peter J. Embi, Sarah W. Ball, Manjusha Gaglani, Nancy Grisel, Julie Arndorfer, Mark W. Tenforde, Katherine E. Fleming-Dutra
Summary: On June 19, 2022, the original monovalent mRNA COVID-19 vaccines were approved for children aged 6 months-4 years (Pfizer-BioNTech) and 6 months-5 years (Moderna). On December 9, 2022, CDC expanded recommendations for the use of updated bivalent vaccines to children aged 6 months and above. Effectiveness of the vaccines ranged from 29% to 80% against COVID-19-like illness in children aged 6 months-5 years, depending on the vaccine type and number of doses given. It is important for all children to stay up to date with recommended COVID-19 vaccines.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
